Rapid loss of oestrogen and progesterone receptors in human leiomyoma and myometrial explant cultures

Molecular Human Reproduction

Volumn 2, Issue 11, 1996, Pages 823-828

  Severino, M F ^a   Murray, M J ^a   Brandon, D D ^b   Clinton, G M ^b   Burry, K A ^a   Novy, M J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Human; Leiomyoma; Myometrium; Oestrogen receptor; Progesterone receptor

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; MESSENGER RNA; PROGESTERONE; PROGESTERONE RECEPTOR;

ARTICLE; DRUG EFFECT; FEMALE; GENETICS; HUMAN; IN VITRO STUDY; LEIOMYOMA; METABOLISM; MYOMETRIUM; NEOPLASM; UTERUS CANCER;

ESTRADIOL; FEMALE; HUMANS; LEIOMYOMA; MYOMETRIUM; NEOPLASMS, HORMONE-DEPENDENT; PROGESTERONE; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RNA, MESSENGER; UTERINE NEOPLASMS;

EID: 0030276064     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/2.11.823     Document Type: Article

References (39)

1. Andersen, J., DyReyes, V.M., Barbieri, R.L. et al. (1995) Leiomyoma primary cultures have elevated transcriptional response to oestrogen compared with autologous myometrial cultures. J. Soc. Gynecol. Invest., 2, 542-551.
2. Balasch, J., Manau, D., Mimo, J. et al. (1995) Sequential gonadotropin-releasing hormone agonists/low-dose oral contraceptive treatment for leiomyomata uteri. Hum. Reprod., 10, 529-532.
3. Brandon, D.D., Bethea, C.L., Strawn, E.Y. et al. (1993) Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human leiomyomas. Am. J. Obstet. Gynecol., 169, 78-85.
4. Brandon, D.D., Erickson, T.E., Keenan, E.J. et al. (1995) Oestrogen receptor gene expression in human uterine leiomyomata. J. Clin. Endocrinol. Metab., 80, 1876-1881.
5. Brosens, I.A., Johannisson, E., Dal Cin, P. et al. (Oct. 1995) Proliferation rate and estrogen dependency of uterine leiomyomas are dependent on the chromosomal pattern. [Abstr. 25]. In Annual Meeting of the American Society for Reproductive Medicine.
6. Burton, K.A. (1956) A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J., 62, 315-322.
7. Buttram, V.C. (1986) Uterine leiomyomata-aetiology, symptomatology, and management. Prog. Clin. Biol. Res., 225, 275-296.
8. Carr, B.R., Marshburn, P.B., Weatherall, P.T. et al. (1993) An evaluation of the effect of gonadotropin-releasing hormone analogs and medroxyprogesterone acetate on uterine leiomyomata volume by magnetic resonance imaging: a prospective, randomized, double-blind, placebo-controlled, crossover trial. J. Clin. Endocrinol. Metab., 76, 1217-1223.
9. Cramer, D.W. (1992) Epidemiology of myomas. Sem. Reprod. Endocrinol., 10, 320-324.
10. Cramer, S.F., Robertson Jr., A.L., Ziats, N.P. et al. (1985) Growth potential of human uterine leiomyomas: some in vitro observations and their implications. Am. J. Obstet. Gynecol., 66, 36-41.
11. Daly, D.C., Walters, C.A., Prior, J.C. et al. (1984) Prolactin production from proliferative phase leiomyoma. Am. J. Obstet. Gynecol., 148, 1059-1063.
12. Ecken, R.L., Rorke, E.A. and Katzenellenbogen, B.S. (1982) Determination of the rates of synthesis and turnover of the oestrogen receptor in MCF-7 breast cancer cells using a density shift technique. [Abstr. 29] In 64th Annual Meeting of the Endocrine Society, San Francisco, CA, USA.
13. Frankel, T. and Benjamin, F. (1973) Rapid enlargement of a uterine fibroid after clomiphene therapy. J. Obstet. Gynaecol. Br. Commonwealth, 80, 764.
14. Friedman, A.J., Barbieri, R.L., Doubilet, P.M. et al. (1988) A randomized, double-blind trial of a gonadotropin releasing hormone agonist (leuprolide) with or without medroxyprogesterone acetate in the treatment of leiomyomata uteri. Fertil. Steril., 149, 404-409.
15. Fritz, M.A., Holmes, R.T. and Keenan, E.J. (1991) Effect of clomiphene citrate treatment on endometrial oestrogen and progesterone receptor induction in women. Am. J. Obstet. Gynecol., 165, 177-185.
16. Harrison-Woolrych, M.L., Charnock-Jones, D.S. and Smith, S.K. (1994) Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction. J. Clin. Endocrinol. Metab., 78, 1179-1184.
17. John, A.H. and Martin, R. (1971) Growth of leiomyomata with estrogen-progesterone therapy. J. Reprod. Med., 6, 49-51.
18. Kassis, J.A., Walent, J.H. and Gorski, J. (1984a) Oestrogen receptors in rat uterine cell culture: effects of medium on receptor concentration. Endocrinology, 115, 762-769.
19. Kassis, J.A., Sakai, D., Walent, J.M. et al. (1984b) Primary cultures of estrogen-responsive cells from rat uteri: Induction of progesterone receptors and a secreted protein. Endocrinology, 114, 1558-1566.
20. Kawaguchi, K., Fujii, S., Konishi, I. et al. (1989) Mitotic activity in uterine leiomyomas during the menstrual cycle. Am. J. Obstet. Gynecol., 160, 637-641.
21. Kazmierczak, B., Hennig, Y., Wanschura, S. et al. (1995) Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldemyde dehydrogenase gene. Cancer Res., 55, 6038-6039.
22. Krosl, J., Breskvar, K. and Hudnik-Plevnik, T. (1989) Prolonged cultivation of rat uterine cells with preserved oestrogen responsiveness. J. Steroid. Biochem., 33, 189-194.
23. Lessey, B.A., Killam, A.P., Metzger, D.A. et al. (1988) Immunohistochemical analysis of human uterine oestrogen and progesterone receptors throughout the menstrual cycle. J. Clin. Endocrinol. Metab., 67, 334-340.
24. Letterie, G.S., Shawker, T.H., Coddington, C.C. et al. (1989) Efficacy of a gonadotropin-releasing hormone agonist in the treatment of uterine leiomyomata: long-term follow-up. Fertil. Steril., 51, 951-956.
25. Meloni, A.M., Surti, V., Contento, A.M. et al. (1992) Uterine leiomyomas: cytogenetic and histologie profile. Obstet. Gynecol., 80, 209-217.
26. Murphy, A.A., Kettle, M., Morales, A.J. et al. (1993) Regression of uterine leiomyomata in response to the antiprogesterone RU-486. J. Clin. Endocrinol. Metab., 76, 513-517.
27. National Center for Health Statistics (1987) Hysterectomies in the United States 1965-84. National Health Survey Series 13. No. 92. DHHS Publication, Maryland, pp. 88-1753.
28. Rauk, P.N., Surti, U., Roberts, J.M. et al. (1995) Mitogenic effect of basic fibroblast growth factor and estradiol on cultured human myometrial and leiomyoma cells. Am. J. Obstet. Gynecol., 173, 571-577.
29. Rein, M.S., Friedman, A.J., Pandian, M.R. et al. (1990) The secretion of insulin-like growth factors I and II by expiant cultures of fibroids and myometrium from women treated with a gonadotropin-releasing hormone agonist. Obstet. Gynecol, 76, 388-394.
30. Rein, M.S., Barbieri, R.L. and Friedman, A.J. (1995a) Progesterone: a critical role in the pathogenesis of uterine myomas. Am. J. Obstet. Gynecol., 172, 14-18.
31. Rein, M.S., Walters, F., Werewicz, S. et al. (1995b) Cytogenetic abnormalities in uterine leiomyomata are associated with leiomyoma size. J. Soc. Gynecol. Invest., 2, 379.
32. Sadan, O., van Iddekinge, B., Savage, N. et al. (1990) Endocrine profile associated with oestrogen and progesterone receptors in leiomyoma and normal myometrium. Gynecol. Endocrinol., 4, 33-42.
33. Sadovsky, Y., Koshner, P.J., Roberts, J.M. et al. (1993) Restoration of oestrogen dependent progesterone receptor expression in a uterine myocyte cell line. Endocrinology, 132, 1609-1613.
34. Sadovsky, Y., Riemer, R.K. and Roberts, J.M. (1992) The concentration of oestrogen receptors in rabbit uterine myocytes decreases in culture. Am. J. Obstet. Gynecol., 167, 1631-1635.
35. Soules, M.R. and McCarty Jr., K.S. (1982) Leiomyomas: steroid receptor content. Variation within normal menstrual cycle. Am. J. Obstet. Gynecol., 143, 6-11.
36. Strawn Jr., E.Y., Novy, M.J., Burry, K.A. et al. (1995) Insulin-like growth factor I promotes leiomyoma cell growth in vitro. Am. J. Obstet. Gynecol., 6, 1837-1843.
37. Tamaya, R., Fujimoto, J. and Okada, M. (1985) Comparison of cellular levels of steroid receptors in uterine leiomyoma and myometrium. Acta Obstet. Gynecol. Scand., 64, 307-309.
38. Vegeto, E., Shahbaz, M.M., Wen, D.X. et al. (1993) Human progesterone receptor A form is a cell-and promoter-specific repressor of progesterone receptor B function. Mol. Endocrinol, 7, 1244-1255.
39. Vollenhoven, B.J., Lawrence, A.S. and Healy, D.L. (1990) Uterine fibroids: a clinical review. Br. J. Obstet. Gynaecol., 97, 258-298.