What I would like to know about leflunomide

Journal of Rheumatology

Volumn 31, Issue 6, 2004, Pages 1029-1031

  Kremer, Joel M ^a,b  

^a ALBANY MEDICAL COLLEGE   (United States)

^b Center for Rheumatology LLP   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; CHARCOAL; COLESTYRAMINE; CYCLOOXYGENASE 2 INHIBITOR; ETANERCEPT; HYDROXYCHLOROQUINE; INFLIXIMAB; LEFLUNOMIDE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SALAZOSULFAPYRIDINE;

ALOPECIA; DIARRHEA; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG INFORMATION; DRUG MECHANISM; DRUG SAFETY; EDITORIAL; ENTEROHEPATIC CIRCULATION; HUMAN; HYPERTENSION; LIVER TOXICITY; MEDICAL INFORMATION; NAUSEA; PRIORITY JOURNAL; RASH; RHEUMATIC DISEASE; SIDE EFFECT; WEIGHT REDUCTION;

ARTHRITIS, RHEUMATOID; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOXAZOLES;

EID: 2642535085     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (15)

1. Smolen J, Emery P, Kalden J, et al. The efficacy of leflunomide monotherapy in rheumatoid arthritis: Towards the goals of DMARD therapy. J Rheumatol 2004;31 Suppl 71:13-20.
2. Kalden J, Smolen J, Emery P, et al. Leflunomide in combination therapy. J Rheumatol 2004;31 Suppl 71:25-32.
3. Van Riel P, Smolen J, Emery P, et al. Leflunomide: A manageable safety profile. J Rheumatol 2004;31 Suppl 71:21-4.
4. Kalden JR, Scott DL, Smolen JS, et al. Improved functional ability in patients with rheumatoid arthritis - longterm treatment with leflunomide versus sulfasalazine. European Leflunomide Study Group. J Rheumatol 2001;28:1983-91.
5. Strand V, Cohen S, Schiff M, et al. Treatment of active rheumatoid arthritis with leflunomide compared with placebo methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Arch Intern Med 1999;159:2542-50.
6. Cohen S, Cannon G, Schiff M, Weaver A, Fox R, Olsen N. Two-year, blinded randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of leflunomide in the Treatment of Rheumatoid Arthritis Investigator Group. Arthritis Rheum 2001;44:1984-92.
7. Weinblatt ME, Kremer JM, Coblyn J, Maier A, Helfgott S, Morell M. Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum 1999;42:1322-8.
8. Kremer JM, Genovese M, Cannon G, Caldwell J, Cush J, Furst D. Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 2002;137:726-33.
9. Kiely P, Johnson D. Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. Rheumatology 2002;41:631-7.
10. Struppler C, Thies W, Schattenkirchner M, Kellner H. Safety and efficacy of leflunomide and infliximab in rheumatoid arthritis patients [abstract]. Ann Rheum Dis 2002;61:S388.
11. Patel S, Bergen W, Kraemer A, Keenan G. Efficacy and safety of Remicade (infliximab) and Arava (leflunomide) in rheumatoid arthritis [abstract]. Arthritis Rheum 2001;44 Suppl:S189.
12. Hansen K, Cush J, Singhal A, Cooley D, Patel S, Genovese M. The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis [abstract]. Arthritis Rheum 2001;44 Suppl: S84.
13. Kremer JM, Genovese M, Cannon GW, et al. Combination of leflunomide and methotrexate therapy for patients with active rheumatoid arthritis failing methotrexate monotherapy: an open-label extension of a randomized, double-blind, placebo-controlled trial. J Rheumatol 2004;31 (in press).
14. Jaimes-Hernandez J, Robles-San Roman M, Suarez-Otero R, Davalos-Zugasti ME, Arroyo-Borrego S. Rheumatoid arthritis treatment with weekly leflunomide: an open-label study. J Rheumatol 2004;31:235-7.
15. Kremer JM. Rheumatological creativity and leflunomide. J Rheumatol 2004;31:203-4.