Ketone bodies could support the motility but not the acrosome reaction of mouse sperm

International Journal of Andrology

Volumn 27, Issue 3, 2004, Pages 172-177

  Tanaka, Hiromitsu ^a   Takahashi, Tohru ^a,b   Iguchi, Naoko ^a   Kitamura, Kouichi ^a   Miyagawa, Yasushi ^a,b   Tsujimura, Akira ^b   Matsumiya, Kiyomi ^b   Okuyama, Akihiko ^b   Nishimune, Yoshitake ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetoacetate; D hydroxybutyrate; Ketone body; Metabolism; Motility; Sperm

Indexed keywords

ACETOACETIC ACID; ALPHA CHLOROHYDRIN; BUTYRIC ACID DERIVATIVE; DEXTRO BETA HYDROXYBUTYRATE; GLUCOSE; KETONE BODY; PYRUVIC ACID; SUCCINYL COENZYME A TRANSFERASE; TRANSFERASE; UNCLASSIFIED DRUG;

ACROSOME REACTION; ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL FUNCTION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME SUBSTRATE; GLYCOLYSIS; MALE; MALE INFERTILITY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPERMATOZOON MOTILITY;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; ACROSOME REACTION; ALPHA-CHLOROHYDRIN; ANIMALS; CULTURE MEDIA; ENZYME INHIBITORS; FLOW CYTOMETRY; KETONE BODIES; MALE; MICE; MICE, INBRED C57BL; SPERM MOTILITY; SPERMATOZOA; SUBSTRATE SPECIFICITY; TRANSGENES;

EID: 2642528705     PISSN: 01056263     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2004.00471.x     Document Type: Article

References (28)

1. Bone, W., Jones, A. R., Morin, C., Nieschlag, E. & Cooper, T. G. (2001) Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro. Journal of Andrology 22, 464-470.
2. Coates, A., Rutherford, A. J., Hunter, H. & Leese, H. J. (1999) Glucose-free medium in human in vitro fertilization and embryo transfer: a large-scale, prospective, randomized clinical trial. Fertility and Sterility 72, 229-232.
3. Cooper, T. G. (1984) The onset and maintenance of hyperactivated motility of spermatozoa from the mouse. Gamete Research 9, 55-74.
4. Ford, W. C. L. & Harrison, A. (1981) The role of oxidative phosphorylation in the generation of ATP in human spermatozoa. Journal of Reproduction Fertility 63, 271-278.
5. Ford, W. C. L. & Rees, J. M. (1990) The bioenergetics of mammalian sperm motility. In: Controls of Sperm Motility: Biological and Clinical Aspects (ed. C. Gagnon), pp. 175-202. CRC Press, Florida.
6. Fraser, L. R. & Quinn, P. J. (1981) A glycolytic product is obligatory for initiation of the sperm acrosome reaction and whiplash motility required for fertilization in the mouse. Journal of Reproduction Fertility 61, 25-35.
7. Fukao, T., Song, X. Q., Mitchell, G. A., Yamaguchi, S., Sukegawa, K., Orii, T. & Kondo, N. (1997) Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases. Pediatric Research 42, 498-502.
8. Koga, M., Tanaka, H., Yomogida, K., Nozaki, M., Tsuchida, J., Ohta, H. et al. (2000) Isolation and characterization of haploid germ cell specific novel cDNA; testis-specific homologue of succinyl CoA: 3-oxo acid CoA transferase (scot-t). Biology of Reproduction 63, 1601-1609.
9. Lardy, H. A. & Phillips, P. H. (1945) Studies of fat and carbohydrate oxidation in mammalian spermatozoa. Archives of Biochemistry 6, 53-61.
10. Lardy, H. A., Hansen, R. G. & Phillips, P. H. (1945) The metabolism of bovine epididymal spermatozoa. Archives of Biochemistry 6, 41-51.
11. Mitchell, G. A., Kassovska-Bratinova, S., Boukaftane, Y., Robert, M. F., Wang, S. P., Ashmarina, L., Lambert, M., Lapierre, P. & Potier, E. (1995) Medical aspects of ketone body metabolism. Clinical and Investigative Medicine 18, 193-216.
12. Mortimer, S. T. (1997) A critical review of the physiological importance and analysis of sperm movement in mammals. Human Reproduction Update 3, 403-439.
13. Nakanishi, T., Ikawa, M., Yamada, S., Parvinen, M., Baba, T., Nishimune, Y. & Okabe, M. (1999) Real-time observation of acrosomal dispersal from mouse sperm using GFP as a marker protein. FEBS Letters 449, 277-283.
14. Neill, J. M. & Olds-Clarke, P. (1987) A computer-assisted assay for mouse sperm hyperactivation demonstrates that bicarbonate but not bovine serum albumin is required. Gamete Research 18, 121-140.
15. Niwa, K. & Iritani, A. (1978) Effect of various hexoses on sperm capacitation and penetration of rat eggs in vitro. Journal of Reproduction Fertility 53, 267-271.
16. Rogers, B. J. & Perreault, S. D. (1990) Importance of glycolysable substrates for in vitro capacitation of human spermatozoa. Biology Reproduction 43, 1064-1069.
17. Suarez, S. (1988) Hamster sperm motility transformation during development of hyperactivation in vitro and epididymal maturation. Gamete Research 19, 51-65.
18. Suarez, S. & Osman, R. A. (1987) Initiation of hyperactivated flagellar bending in mouse sperm within the female reproductive tract. Biology of Reproduction 36, 1191-1198.
19. Suarez, S., Varosi, S. M. & Dai, X. (1993) Intracellular calcium increases with hyperactivation in intact, moving hamster sperm and oscillates with the flagellar beat cycle. Proceeding of National Academy Sciences USA 90, 4660-4664.
20. Suter, D., Chow, P. Y. W. & Martin, I. C. A. (1979) Maintenance of motility in human spermatozoa by energy derived through oxidative phosphorylation and addition of albumin. Biology of Reproduction 20, 505-510.
21. Tanaka, H., Kohroki, J., Iguchi, N., Onishi, M. & Nishimune, Y. (2001a) Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA. Molecular Human Reproduction 8, 16-23.
22. st Century. Proceeding of VIIth International Congress of Andrology (eds B. Robaire, H. Chemes & C. R. Morales), pp. 157-161. Medimond Press, Montreal, Canada.
23. Tanaka, H., Iguchi, N., Miyagawa, Y., Koga, M., Kohroki, J. & Nishimune, Y. (2003) Differential expression of succinyl CoA transferase (SCOT) genes in somatic and germline cells of the mouse testis. International Journal of Andrology 26, 52-56.
24. Toyoda, Y., Yokoyma, M. & Hoshi, T. (1971) Studies on the fertilization of mouse eggs in vivo. I. In vivo fertilization of eggs by fresh epididymal sperm. Japanese Journal of Animal Reproduction 16, 147-151.
25. Welch, J. E., Schatte, E. C., O'Brien, D. A. & Eddy, E. M. (1992) Expression of a glyceraldehydes 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells. Biology of Reproduction 46, 869-878.
26. Williams, A. C. & Ford, C. L. (2001) The role of glucose in supporting motility and capacitation in human spermatozoa. Journal of Andrology 22, 680-695.
27. Williamson, D. H., Bates, M. W., Page, M. A. & Krebs, H. A. (1971) Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues. Biochemical Journal 121, 41-47.
28. Yanagimachi, R. (1979) The movement of golden hamster spermatozoa before and after capacitation. Journal of Reproduction Fertility 23, 193-196.