Marrubenol interacts with the phenylalkylamine binding site of the L-type calcium channel

European Journal of Pharmacology

Volumn 492, Issue 2-3, 2004, Pages 269-272

  El Bardai, Sanae ^a,b   Hamaide, Marie Christine ^a   Lyoussi, Badiaa ^b   Quetin Leclercq, Joëlle ^a   Morel, Nicole ^a   Wibo, Maurice ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b SIDI MOHAMED BEN ABDELLAH UNIVERSITY   (Morocco)

Author keywords

1,4 Dihydropyridine; Calcium antagonist; L type Ca2+ channel; Marrubenol; Phenylalkylamine

Indexed keywords

1,4 DIHYDROPYRIDINE; CALCIUM ANTAGONIST; CALCIUM CHANNEL L TYPE; DEVAPAMIL; MARRUBENOL; MARRUBIUM VULGARE EXTRACT; PHENYLALKYLAMINE; PLANT EXTRACT; POTASSIUM CHLORIDE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTERY; ARTERY CONSTRICTION; ARTICLE; CONCENTRATION RESPONSE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEPOLARIZATION; DRUG BINDING; DRUG BINDING SITE; INTESTINE MUSCLE; MARRUBIUM; MARRUBIUM VULGARE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DIHYDROPYRIDINES; DITERPENES; FURANS; ILEUM; ISRADIPINE; MALE; MEMBRANES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; POTASSIUM CHLORIDE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; VASODILATOR AGENTS; VERAPAMIL;

EID: 2642517790     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.04.007     Document Type: Article

References (8)

1. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:1973;3099-3108
2. Dessy C., Godfraind T. The effect of L-type calcium channel modulators on the mobilization of intracellular calcium stores in guinea-pig intestinal smooth muscle. Br. J. Pharmacol. 119:1996;142-148
3. El Bardai S., Morel N., Wibo M., Fabre N., Llabres G., Lyoussi B., Quetin-Leclercq J. The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgare. Planta Med. 69:2003;75-77
4. El Bardai S., Wibo M., Hamaide M.-C., Lyoussi B., Quetin-Leclercq J., Morel N. Characterisation of marrubenol, a diterpene extracted from Marrubium vulgare, as an L-type calcium channel blocker. Br. J. Pharmacol. 140:2003;1211-1216
5. Godfraind T., Miller R., Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol. Rev. 38:1986;321-416
6. McPherson G.A. Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. J. Pharmacol. Methods. 14:1985;213-228
7. 2+ channel in cardiac tissue. Eur. J. Pharmacol. 280:1995;155-158
8. 2+-channel modulators in rat intestinal smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 344:1991;698-705