Role of auxiliary β1-, β2-, and β3-subunits and their interaction with Nav1.8 voltage-gated sodium channel

Biochemical and Biophysical Research Communications

Volumn 319, Issue 2, 2004, Pages 531-540

  Vijayaragavan, Kausalia ^a   Powell, Andrew J ^b   Kinghorn, Ian J ^b   Chahine, Mohamed ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Subunits; C fibers; Decay kinetics; Dorsal root ganglion; Expression levels; Nav1.8; Steady state properties; Voltage clamp; Voltage gated sodium channels; Xenopus oocytes

Indexed keywords

SODIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL; NA(V)1.8 PROTEIN, RAT; NERVE PROTEIN;

ANIMAL CELL; ARTICLE; BETA CHAIN; DEPOLARIZATION; FEMALE; MICROELECTRODE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; RAT; SODIUM CURRENT; STEADY STATE; VOLTAGE CLAMP; XENOPUS LAEVIS; ANIMAL; CHEMISTRY; METABOLISM; PATCH CLAMP; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; XENOPUS LAEVIS;

EID: 2642514674     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.05.026     Document Type: Article

References (32)

1. + channels. Jpn. J. Pharmacol. 88:2002;365-377
2. Isom L.L. The role of sodium channels in cell adhesion. Front. Biosci. 7:2002;12-23
3. Yu F.H., Westenbroek R.E., Silos-Santiago I., McCormick K.A., Lawson D., Ge P., Ferriera H., Lilly J., Distefano P.S., Catterall W.A., Scheuer T., Curtis R. Sodium channel β4, a new disulfide-linked auxiliary subunit with similarity to β2. J. Neurosci. 23:2003;7577-7585
4. Isom L.L., Ragsdale D.S., De Jongh K.S., Westenbroek R.E., Reber B.F.X., Scheuer T., Catterall W.A. Structure and function of the β2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 83:1995;433-442
5. Malhotra J.D., Kazen-Gillespie K., Hortsch M., Isom L.L. Sodium channel β subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. J. Biol. Chem. 275:2000;11383-11388
6. Malhotra J.D., Koopmann M.C., Kazen-Gillespie K.A., Fettman N., Hortsch M., Isom L.L. Structural requirements for interaction of sodium channel β1 subunits with ankyrin. J. Biol. Chem. 277:2002;26681-26688
7. Morgan K., Stevens E.B., Shah B., Cox P.J., Dixon A.K., Lee K., Pinnock R.D., Hughes J., Richardson P.J., Mizuguchi K., Jackson A.P. β3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc. Natl. Acad. Sci. USA. 97:2000;2308-2313
8. + channel function in the extracellular domain of the β1 subunit. J. Biol. Chem. 273:1998;3954-3962
9. Ratcliffe C.F., Westenbroek R.E., Curtis R., Catterall W.A. Sodium channel β1 and β3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain. J. Cell Biol. 154:2001;427-434
10. Nuss H.B., Chiamvimonvat N., Pérez-garcía M.T., Tomaselli G.F., Marbán E. Functional association of the β1 subunit with human cardiac (hH1) and rat skeletal muscle (μ1) sodium channel α subunits expressed in Xenopus oocytes. J. Gen. Physiol. 106:1995;1171-1191
11. Kazen-Gillespie K.A., Ragsdale D.S., D'Andrea M.R., Mattei L.N., Rogers K.E., Isom L.L. Cloning, localization, and functional expression of sodium channel β1A subunits. J. Biol. Chem. 275:2000;1079-1088
12. 1 and type IIA α subunits of sodium channels in a mammalian cell line J. Biol. Chem. 270:1995;3306-3312
13. v1.8 peripheral nerve sodium channels. J. Neurosci. 21:2001;7909-7918
14. Novakovic S.D., Tzoumaka E., McGivern J.G., Haraguchi M., Sangameswaran L., Gogas K.R., Eglen R.M., Hunter J.C. Distribution of the tetrodotoxin- resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J. Neurosci. 18:1998;2174-2187
15. McCormick K.A., Srinivasan J., White K., Scheuer T., Catterall W.A. The extracellular domain of the β1 subunit is both necessary and sufficient for β1-like modulation of sodium channel gating. J. Biol. Chem. 274:1999;32638-32646
16. + channels J. Neurosci. 16:1996;7117-7127
17. Qu Y., Rogers J.C., Chen S.F., McCormick K.A., Scheuer T., Catterall W.A. Functional roles of the extracellular segments of the sodium channel α subunit in voltage-dependent gating and modulation by β1 subunits. J. Biol. Chem. 274:1999;32647-32654
18. 1 subunit modifies activation and inactivation gating of multiple sodium channel α subunits J. Biol. Chem. 269:1994;17649-17655
19. Zur K.B., Oh Y., Waxman S.G., Black J.A. Differential up-regulation of sodium channel alpha- and beta 1-subunit mRNAs in cultured embryonic DRG neurons following exposure to NGF. Brain Res. Mol. Brain Res. 30:1995;97-105
20. Blackburn-Munro G., Fleetwood-Walker S.M. The sodium channel auxiliary subunits β1 and β2 are differentially expressed in the spinal cord of neuropathic rats. Neuroscience. 90:1999;153-164
21. Coward K., Jowett A., Plumpton C., Powell A., Birch R., Tate S., Bountra C., Anand P. Sodium channel β1 and β2 subunits parallel SNS/PN3 α-subunit changes in injured human sensory neurons. Neuroreport. 12:2001;483-488
22. Krieg P.A., Melton D.A. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acids Res. 12:1984;7057-7070
23. Shih T.M., Smith R.D., Toro L., Goldin A.L. High-level expression and detection of ion channels in Xenopus oocytes. Methods Enzymol. 293:1998;529-556
24. v1.3 sodium channels, expressed in mammalian cells, by auxiliary β1, β2 and β3 subunits. Neuroscience. 114:2002;745-753
25. V1.8(SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23. Neuropharmacology. 46:2004;425-438
26. Qu Y., Curtis R., Lawson D., Gilbride K., Ge P., Distefano P.S., Silos-Santiago I., Catterall W.A., Scheuer T. Differential modulation of sodium channel gating and persistent sodium currents by the β1, β2, and β3 subunits. Mol. Cell. Neurosci. 18:2001;570-580
27. Cummins T.R., Aglieco F., Renganathan M., Herzog R.I., Dib-Hajj S.D., Waxman S.G. Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons. J. Neurosci. 21:2001;5952-5961
28. 1 subunit J. Gen. Physiol. 120:2002;887-895
29. v1.8 sodium channels to action potential electrogenesis in DRG neurons. J. Neurophysiol. 86:2001;629-640
30. Shah B.S., Stevens E.B., Gonzalez M.I., Bramwell S., Pinnock R.D., Lee K., Dixon A.K. Beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain. Eur. J. Neurosci. 12:2000;3985-3990
31. Abdulla F.A., Smith P.A. Changes in Na(+) channel currents of rat dorsal root ganglion neurons following axotomy and axotomy-induced autotomy. J. Neurophysiol. 88:2002;2518-2529
32. v1.8 in uninjured axons enables neuropathic pain. J. Neurosci. 23:2003;158-166