Clinical outcome in patients with complete pathologic response (pT0) to preoperative irradiation/chemo-irradiation operated for locally advanced or locally recurrent rectal cancer

Journal of Surgical Oncology

Volumn 92, Issue 1, 2005, Pages 70-75

  Wiig, Johan N ^a   Larsen, Stein G ^a   Dueland, Svein ^a   Giercksky, Karl Erik ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Advanced rectal cancer; Local recurrence; Preoperative chemoradiation; Survival

Indexed keywords

ANTIBIOTIC AGENT; DOXYCYCLINE; ENOXAPARIN; FLUOROURACIL; FOLINIC ACID; METRONIDAZOLE; OXALIPLATIN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; COMPUTER ASSISTED TOMOGRAPHY; DEEP VEIN THROMBOSIS; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTOPERATIVE INFECTION; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM ANTERIOR RESECTION; RECTUM CANCER; TREATMENT OUTCOME;

ADENOCARCINOMA; ADULT; AGED; COMBINED MODALITY THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PREOPERATIVE CARE; RECTAL NEOPLASMS; SURVIVAL ANALYSIS;

EID: 26244458521     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/jso.20340     Document Type: Article

References (20)

1. Frykholm G, Glimelius B, Pahlman L: Preoperative irradiation with and without chemotherapy (MFL) in the treatment of primarily non-resectable adenocarcinoma of the rectum. Results from two consecutive studies. Eur J Cancer Clin Oncol 1989; 25:1535-1541.
2. Gunderson LL, Haddock MG, Nelson H, et al.: Locally recurrent colorectal cancer: IOERT and EBRT +/-5-FU and maximal resection. Front Radiat Ther Oncol 1997;31:224-228.
3. Gunderson LL, Sosin H: Areas of failure found at reoperation (second or symptomatic look) following "curative surgery" for adenocarcinoma of the rectum. Clinicopathologic correlation and implications for adjuvant therapy. Cancer 1974;34:1278-1292.
4. Onaitis MW, Noone RB, Fields R, et al.: Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival. Ann Surg Oncol 2001;8:801-806.
5. Theodoropoulos G, Wise WE, Padmanabhan A, et al.: T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum 2002;45:895-903.
6. Quirke P, Dixon MF: The prediction of local recurrence in rectal adenocarcinoma by histopathological examination. Int J Colorect Dis 1988;3:127-131.
7. Wibe A, Rendedal PR, Svensson E, et al.: Prognostic significance of the circumferential margin following total mesorectal excision for rectal cancer. Br J Surg 2002;89:327-334.
8. Wiig JN, Tveit KM, Poulsen JP, et al.: Preoperative irradiation and surgery for recurrent rectal cancer. Will intraoperative irradiation (IORT) be of additional benefit? A prospective study. Radiother Oncol 2002;62:207-213.
9. Giercksky KE, Danielsen S, Garberg O, et al.: A single dose tinidazole and doxycycline prophylaxis in elective surgery of colon and rectum. A prospective controlled clinical multicenter study. Ann Surg 1982;195:227-231.
10. Wiig JN, Wolff PA, Tveit KM, et al.: Location of pelvic recurrence after 'curative' low anterior resection for rectal cancer. Eur J Surg Oncol 1999;25:590-594.
11. Wibe A, Moller B, Norstein J, et al.: A national strategic change in treatment policy for rectal cancer-implementation of total mesorectal excision as routine treatment in Norway. A national audit. Dis Colon Rectum 2002;45:857-866.
12. Kim HK, Jessup JM, Beard CJ, et al.: Locally advanced rectal carcinoma: Pelvic control and morbidity following preoperative radiation therapy, resection, and intraoperative radiation therapy. Int J Radiat Oncol Biol Phys 1997;38:777-783.
13. Ruo L, Tickoo S, Klimstra DS, et al.: Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy. Ann Surg 2002;236:75-81.
14. Janjan NA, Abbruzzese J, Pazdur R, et al.: Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer. Radiother Oncol 1999;51:153-160.
15. Moore HG, Gittleman AE, Minsky BD, et al.: Rate of pathologic-complete response with increased interval between preoperative combined modality therapy and rectal cancer resection. Dis Colon Rectum 2004;47:279-286.
16. Mohiuddin M, Hayne M, Regine WF, et al.: Prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent rectal cancers. Int J Radiat Oncol Biol Phys 2000;48:1075-1080.
17. Reerink O, Verschueren RC, Szabo BG, et al.: A favourable pathological stage after neoadjuvant radiochemotherapy in patients with initially irresectable rectal cancer correlates with a favourable prognosis. Eur J Cancer 2003;39:192-195.
18. Garcia-Aguilar J, Hernandez dA, Sirivongs P, et al.: A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision. Dis Colon Rectum 2003; 46:298-304.
19. Ng IO, Luk IS, Yuen ST, et al.: Surgical lateral clearance in resected rectal carcinomas. A multivariate analysis of clinicopathologic features [see comments]. Cancer 1993;71:1972-1976.
20. Bouzourene H, Bosman FT, Seelentag W, et al.: Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer 2002;94:1121-1130.