Effects of L-carnitine on thyroid hormone metabolism and on physical exercise tolerance

Hormone and Metabolic Research

Volumn 37, Issue 9, 2005, Pages 566-571

  Benvenga, Salvatore ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

L carnitine; Nutrients; Physical exercise; Sports; Thyroid hormone modulators

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINE; ASPARTATE AMINOTRANSFERASE; CARNITINE; CHOLESTEROL; CREATINE KINASE; CYTOCHROME C OXIDASE; FATTY ACID; FERRITIN; GAMMA GLUTAMYLTRANSFERASE; GLYCOGEN; HYDROXYPROLINE; IODINE 125; LACTIC ACID; LEVACECARNINE; LIOTHYRONINE; LONG CHAIN FATTY ACID; NON PRESCRIPTION DRUG; ORGANIC CATION TRANSPORTER; OSTEOCALCIN; PLACEBO; PYRUVATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SEX HORMONE BINDING GLOBULIN; SUCCINATE DEHYDROGENASE; THYROID HORMONE; THYROID HORMONE RECEPTOR; THYROTROPIN; THYROXINE; UNINDEXED DRUG;

ATHLETE; BIOSYNTHESIS; CLINICAL TRIAL; CONFERENCE PAPER; DIETARY INTAKE; DRUG UPTAKE; ENERGY METABOLISM; EXERCISE TOLERANCE; HORMONE ACTION; HUMAN; HYPERTHYROIDISM; MUSCLE LEVEL; NONHUMAN; PERFORMANCE; PRIORITY JOURNAL; REGULATORY MECHANISM; SKELETAL MUSCLE; SPORT; SUPPLEMENTATION; THYROID CRISIS; THYROID HORMONE METABOLISM;

ANIMALS; CARNITINE; DIETARY SUPPLEMENTS; ENERGY METABOLISM; EXERCISE; EXERCISE TOLERANCE; HUMANS; MUSCLE, SKELETAL; THYROID HORMONES;

ANIMALIA;

EID: 26244458153     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-870424     Document Type: Conference Paper

References (33)

1. Loster H. Biochemical fundamentals of the effects of carnitine. In: Loster H (ed). Carnitine and Cardiovascular Diseases. Bochum: Ponte Press Verlags, 2003: 3-48
2. Anonymous. Recipes of All Nations. New York: WM Wise & Co, USA, 1935:779-781
3. Tamai I, Ohashi R, Nezu J, Yabuchi H, Oku A, Shimane M, Say Y, Tsuji A. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter (OCTN2). J Biol Chem 1998; 273: 20378-20382
4. Rebouche CJ. Carnitine movement across muscle cell membranes. Biochem Biophys Acta 1977; 471: 145-155
5. Huth PJ, Schmidt MJ, Hall PV, Fariello RG, Shug AL. The uptake of carnitine by slices of rat cerebral cortex. J Neurochem 1981; 36: 715-723
6. Cederblad G, Lindstedt S, Lundholm K. Concentration of carnitine in human muscle tissue. Clin Chim Acta 1974; 53: 311-321
7. Rebouche CJ. Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Ann NY Acad Sci 2004; 1033: 30-41
8. Arenas J, Huertas R, Campos Y, Diaz AE, Villalon JM, Vilas E. Effects of L-carnitine on the pyruvate dehydrogenase complex and carnitine palmitoyl transferase in muscle athletes. FEBS Lett 1994; 341: 91-93
9. Arenas J, Ricoy JR, Encinas AR, Pola P, D'Iddio S, Zeviani M, Di Donato S, Corsi M. Carnitine in muscle, serum and urine of non-professional athletes; effects of physical exercise, training, and L-carnitine administration. Muscle & Nerve 1991; 14: 598-604
10. Lohninger A, Kaiser E, Legenstein E, Staniek H. Carnitine: Metabolism and function. In: Kaiser E, Lohninger A, eds. Carnitine, its role in lung and heart disorders. Proceeding of the Satellite Symposium of the Central European Congress of Aenesthesiology (ZAK), Graz (Austria), September 13, 1985. Basel, New York: Karger, 1985: 1-25
11. Brass EP, Hiatt WR. The role of carnitine and carnitine supplementation during excercise in man and in individuals with special needs. J Am Coll Nutr 1998; 17: 207-215
12. Brass EP. Supplemental carnitine and exercise. Am J Clin Nutr 2000; 72: 618S-623S
13. Brass EP. Carnitine and sports medicine: use or abuse? Ann NY Acad Sci 2004; 1033: 67-78
14. Benvenga S, Lakshmanan M, Trimarchi F. Carnitine is a naturally occurring inhibitor of thyroid hormone nuclear uptake. Thyroid 2000; 12: 1043-1050
15. Benvenga S, Ruggeri RM, Russo A, Lapa D, Campennì A, Trimarchi F. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized double-blind, placebo-controlled clinical trial. J Clin Endocrinol Metab 2001; 86: 3579-3594
16. Benvenga S, Lapa D, Cannavò S, Trimarchi F. Successive thyroid storms treated with L-carnitine and low doses of methimazole. Am J Med 2003; 115: 417-418
17. Neumann G. Effects of L-carnitine in elite athletes. In: Seim H, Loster H (Eds). Carnitine: Pathobiochemical basics and clinical applications. Bochum: Ponte Press Verlags, 1996: 61-71
18. Luppa D, Loster H. L-carnitine through urine and sweat in athletes in dependence on energy expenditures during training. Bochum: Ponte Press Verlags, 1996: 278-279
19. 2 max and aerobic-anaerobic threshold in normoxia and acute hypoxia. Eur J Appl Physiol 1990; 60: 1-6
20. Decombaz J, Deriaz O, Acheson K, Gmuender B, Jequier E. Effect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogen. Med Sci Sports Exerc 1993; 25: 733-740
21. Barnett C, Costill DL, Vukovich MD et al. Effect of L-carnitine supplementation on muscle and blood carnitine content and lactate accumulation during high-intensity sprint cycling. Int J Sports Nutr 1994; 4: 280-228
22. Vukovich MD, Costill DL, Fink WJ. Carnitine supplementation: effect on muscle carnitine and glycogen content during exercise. Med Sci Sports Exerc 1994; 26: 1122-1129
23. Cooper MB, Jones DA, Edwards RH, Corbucci GC, Montanari G, Trevisani C. The effect of marathon running on carnitine metabolism and on some aspects of muscle mitochondrial activities and antioxidant mechanisms. J Sport Sciences 1986; 4: 79-87
24. Dragan GI, Vasiliu A, Georgescu E, Dumas L. Studies concerning chronic and acute effects of L-carnitine on some biological parameters in elite athletes. Physiologie 1987; 24: 23-28
25. Huertas R, Campos Y, Diaz E, Esteban J, Vecchietti L, Montanari G, D'Iddio S, Corbi M, Arenas J. Respiratory chain enzymes in muscle of endurance athletes: effect of L-carnitine. Biochem Biophys Res Commun 1992; 188: 102-107
26. Millington DS, Dubag G. Dietary supplement L-carnitine: analysis of different brands to determine bioavailability and content. Clin Res Reg Affairs 1993; 10: 71-80
27. Bremer J. Carnitine - metabolism and function. Physiol Rev 1983; 63: 1420-1480
28. Christinasen RZ, Bremer J. Active transport of butyrobetaine and carnitine into isolated liver cells. Biochim Biopys Acta 1976; 444: 562-577
29. Hiatt WR. Carnitine and peripheral arterial disease. Ann NY Acad Sci 2004; 1033: 92-98
30. Alesci S, De Martino MU, Mirani M, Benvenga S, Trimarchi F, Kino T, Chrousos GO. L-carnitine a nutritional modulator of glucocorticoid receptor functions. FASEB J 2003; 17: 1553-1555
31. Maebashi M, Kawamura N, Sato M, Imamura A, Yoshinaga K, Suzuki M. Urinary excretion of carnitine in patients with hyperthyroidism and hypothyroidism: augmentation by thyroid hormone. Metabolism 1977; 26: 351-356
32. Cederblad G, Engstrom G. Effect of thyroxine treatment on carnitine levels in mice. Acta Pharmacol et Toxicol 1978; 43: 1-5
33. Reed HL. Environmental influences upon thyroid hormone regulation. In: Braverman LE, Utoger RD (eds). Werner and Ingbar's The thyroid. A fundamental and clinical text. Philadelphia: Lippincott Williams & Wilkins, 2005: 219-229