메뉴 건너뛰기




Volumn 34, Issue 3, 2005, Pages 237-242

Pharmacokinetics and pharmacodynamics of a therapeutic dose of unfractionated heparin (200 U/kg) administered subcutaneously or intravenously to healthy dogs

Author keywords

Antifactor Xa activity; Coagulation test; Dog; Unfractionated heparin

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

EID: 26244449099     PISSN: 02756382     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-165X.2005.tb00047.x     Document Type: Article
Times cited : (28)

References (26)
  • 1
    • 2742562143 scopus 로고
    • Les héparines
    • Sampol J, Arnoux D, Boutière B, eds. Paris, France: Elsevier
    • Boneu B. Les héparines [Heparin]. In: Sampol J, Arnoux D, Boutière B, eds. Manuel d'Hémostase. Paris, France: Elsevier; 1995:691-706.
    • (1995) Manuel d'Hémostase , pp. 691-706
    • Boneu, B.1
  • 2
    • 0026704979 scopus 로고
    • Relationship between dose, anticoagulant effect and the clinical efficacy of heparin
    • Lane DA, Björk I, Lindahl U, eds. New York, NY: Plenum Press
    • Hirsh J. Relationship between dose, anticoagulant effect and the clinical efficacy of heparin. In: Lane DA, Björk I, Lindahl U, eds. Heparin and Related Polysaccharides. New York, NY: Plenum Press; 1992:283-295.
    • (1992) Heparin and Related Polysaccharides , pp. 283-295
    • Hirsh, J.1
  • 3
    • 0042632412 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation in dogs and cats
    • Couto CG. Disseminated intravascular coagulation in dogs and cats. Vet Med. 1999; June:547-554.
    • (1999) Vet Med , vol.JUNE , pp. 547-554
    • Couto, C.G.1
  • 4
    • 0018613750 scopus 로고
    • Disseminated intravascular coagulation: A review of its pathogenesis, manifestations and treatment
    • Moore DJ. Disseminated intravascular coagulation: a review of its pathogenesis, manifestations and treatment. J S Afr Vet Assoc. 1979;50:259-264.
    • (1979) J S Afr Vet Assoc , vol.50 , pp. 259-264
    • Moore, D.J.1
  • 5
    • 0023873634 scopus 로고
    • Disseminated intravascular coagulation
    • Slappendel RJ. Disseminated intravascular coagulation. Vet Clin North Am. 1988;18:169-184.
    • (1988) Vet Clin North Am , vol.18 , pp. 169-184
    • Slappendel, R.J.1
  • 6
    • 0141993042 scopus 로고    scopus 로고
    • Hemostatic changes in dogs with naturally occurring sepsis
    • De Laforcade AM, Freeman LM, Shaw SP, et al. Hemostatic changes in dogs with naturally occurring sepsis. J Vet Intern Med. 2003;17:674-679.
    • (2003) J Vet Intern Med , vol.17 , pp. 674-679
    • De Laforcade, A.M.1    Freeman, L.M.2    Shaw, S.P.3
  • 7
    • 4344674532 scopus 로고    scopus 로고
    • The incidence of disseminated intravascular coagulation in dogs with malignant tumor
    • Maruyama H, Miura T, Sakai M, et al. The incidence of disseminated intravascular coagulation in dogs with malignant tumor. J Vet Med Sci. 2004;66:573-575.
    • (2004) J Vet Med Sci , vol.66 , pp. 573-575
    • Maruyama, H.1    Miura, T.2    Sakai, M.3
  • 8
    • 0042381740 scopus 로고    scopus 로고
    • Diagnosis and treatment of disseminated intravascular coagulation
    • Bakhshi S, Arya LS. Diagnosis and treatment of disseminated intravascular coagulation. Indian Pediatr. 2003;40:721-730.
    • (2003) Indian Pediatr , vol.40 , pp. 721-730
    • Bakhshi, S.1    Arya, L.S.2
  • 10
    • 0019556031 scopus 로고
    • Clinical pharmacology of heparin
    • Byars TD, Wilson RC. Clinical pharmacology of heparin. J Am Vet Med Assoc. 1981;178:739-740.
    • (1981) J Am Vet Med Assoc , vol.178 , pp. 739-740
    • Byars, T.D.1    Wilson, R.C.2
  • 11
    • 0021824554 scopus 로고
    • Effect of sodium heparin and antithrombin III concentration on activated plasma thromboplastin time in the dog
    • Hellebrekers LJ, Slappendel RJ, Van den Brom WE. Effect of sodium heparin and antithrombin III concentration on activated plasma thromboplastin time in the dog. Am J Vet Res. 1985;46:1460-1462.
    • (1985) Am J Vet Res , vol.46 , pp. 1460-1462
    • Hellebrekers, L.J.1    Slappendel, R.J.2    Van Den Brom, W.E.3
  • 12
    • 0034981287 scopus 로고    scopus 로고
    • The monitoring of heparin administration by screening tests in experimental dogs
    • Mischke R, Jacobs C. The monitoring of heparin administration by screening tests in experimental dogs. Res Vet Sci. 2001;70:101-108.
    • (2001) Res Vet Sci , vol.70 , pp. 101-108
    • Mischke, R.1    Jacobs, C.2
  • 13
    • 0035195868 scopus 로고    scopus 로고
    • Anticoagulation effects of repeated subcutaneous injections of high doses of unfractionated heparin in healthy dogs
    • Mischke R, Schuttert C, Grebe SI. Anticoagulation effects of repeated subcutaneous injections of high doses of unfractionated heparin in healthy dogs. Am J Vet Res. 2001;62:1887-1891.
    • (2001) Am J Vet Res , vol.62 , pp. 1887-1891
    • Mischke, R.1    Schuttert, C.2    Grebe, S.I.3
  • 14
    • 0033218473 scopus 로고    scopus 로고
    • Pharmakokinetik des unfraktionierten heparins Liquemin beim hund nach intravenöser und subkutaner injektion basierend auf der heparin aktivität
    • Jacobs C, Grebe S, Kietzmann M, et al. Pharmakokinetik des unfraktionierten heparins Liquemin beim hund nach intravenöser und subkutaner injektion basierend auf der heparin aktivität [Pharmacokinetics of an unfractionated heparin (Liquemin) in the dog after intravenous and subcutaneous application based on heparin activity]. Dtsch Tierarztl Wochenschr. 1999;106:478-481.
    • (1999) Dtsch Tierarztl Wochenschr , vol.106 , pp. 478-481
    • Jacobs, C.1    Grebe, S.2    Kietzmann, M.3
  • 15
    • 0020362545 scopus 로고
    • Kinetics of intravenously administrated heparin in normal humans
    • De Swart CAM, Nijmeyer B, Roelofs JMM, et al. Kinetics of intravenously administrated heparin in normal humans. Blood. 1982;60:1251-1258.
    • (1982) Blood , vol.60 , pp. 1251-1258
    • De Swart, C.A.M.1    Nijmeyer, B.2    Roelofs, J.M.M.3
  • 16
    • 0025174959 scopus 로고
    • Monitoring heparin therapy: Relationship between the activated partial thromboplastin time and heparin assays based on ex-vivo heparin samples
    • Van den Besselaar AMHP, Meeuwisse-Braun J, Jansen-Gruter R, et al. Monitoring heparin therapy: relationship between the activated partial thromboplastin time and heparin assays based on ex-vivo heparin samples. Thromb Haemost. 1990;63:16-23.
    • (1990) Thromb Haemost , vol.63 , pp. 16-23
    • Van Den Besselaar, A.M.H.P.1    Meeuwisse-Braun, J.2    Jansen-Gruter, R.3
  • 17
    • 0024405893 scopus 로고
    • Unfractionated heparin and CY 216: Pharmacokinetics and bioavailabilities of the antifactor Xa and IIa effects after intravenous and subcutaneous injection in the rabbit
    • Briant L, Caranobe C, Saivin S, et al. Unfractionated heparin and CY 216: pharmacokinetics and bioavailabilities of the antifactor Xa and IIa effects after intravenous and subcutaneous injection in the rabbit. Thromb Haemost. 1989;61:348-353.
    • (1989) Thromb Haemost , vol.61 , pp. 348-353
    • Briant, L.1    Caranobe, C.2    Saivin, S.3
  • 18
    • 0023948862 scopus 로고
    • Pharmacokinetic studies of standard unfractionated heparin and low molecular weight heparin in the rabbit
    • Boneu B, Caranobe C, Cadroy Y, et al. Pharmacokinetic studies of standard unfractionated heparin and low molecular weight heparin in the rabbit. Semin Thromb Haemost. 1988;14:18-27.
    • (1988) Semin Thromb Haemost , vol.14 , pp. 18-27
    • Boneu, B.1    Caranobe, C.2    Cadroy, Y.3
  • 20
    • 0022501847 scopus 로고
    • Heparin fractions with high and low affinity to antithrombin III are cleared at different rates
    • Caranobe C, Petitou M, Dupouy D, et al. Heparin fractions with high and low affinity to antithrombin III are cleared at different rates. Thromb Res. 1986;43:635-641.
    • (1986) Thromb Res , vol.43 , pp. 635-641
    • Caranobe, C.1    Petitou, M.2    Dupouy, D.3
  • 21
    • 0023223971 scopus 로고
    • Evidence for a saturable mechanism of disappearance of standard heparin in rabbits
    • Boneu B, Caranobe C, Gabaig AM, et al. Evidence for a saturable mechanism of disappearance of standard heparin in rabbits. Thromb Res. 1987;46:835-844.
    • (1987) Thromb Res , vol.46 , pp. 835-844
    • Boneu, B.1    Caranobe, C.2    Gabaig, A.M.3
  • 22
    • 85084723989 scopus 로고
    • Pharmacokinetics of heparin and related polysaccharides
    • Boneu B, Dol F, Caranobe C, et al. Pharmacokinetics of heparin and related polysaccharides. Ann N Y Acad Sci. 1989;74:1577-1582.
    • (1989) Ann N Y Acad Sci , vol.74 , pp. 1577-1582
    • Boneu, B.1    Dol, F.2    Caranobe, C.3
  • 23
    • 0022402670 scopus 로고
    • Disappearance of circulating anti-Xa activity after intravenous injection of standard heparin and of a low molecular weight heparin (CY 216) in normal and nephrectomized rabbits
    • Caranobe C, Barret A, Gabaig AM, et al. Disappearance of circulating anti-Xa activity after intravenous injection of standard heparin and of a low molecular weight heparin (CY 216) in normal and nephrectomized rabbits. Thromb Res. 1985;40:129-133.
    • (1985) Thromb Res , vol.40 , pp. 129-133
    • Caranobe, C.1    Barret, A.2    Gabaig, A.M.3
  • 24
    • 0023636977 scopus 로고
    • Pharmacokinetics of heparin and low molecular weight heparin fragment (Fragmin) in rabbits with impaired renal or metabolic clearance
    • Palm M, Mattsson C. Pharmacokinetics of heparin and low molecular weight heparin fragment (Fragmin) in rabbits with impaired renal or metabolic clearance. Thromb Haemost. 1987;58:932-935.
    • (1987) Thromb Haemost , vol.58 , pp. 932-935
    • Palm, M.1    Mattsson, C.2
  • 25
    • 0030679685 scopus 로고    scopus 로고
    • Inability of the activated partial thromboplastin time to predict heparin levels. Time to reassess guidelines for heparin assays
    • Baker BA, Adelman MD, Smith PA, Osborn JC. Inability of the activated partial thromboplastin time to predict heparin levels. Time to reassess guidelines for heparin assays. Arch Intern Med. 1997;157:2475-2479.
    • (1997) Arch Intern Med , vol.157 , pp. 2475-2479
    • Baker, B.A.1    Adelman, M.D.2    Smith, P.A.3    Osborn, J.C.4
  • 26
    • 0030057043 scopus 로고    scopus 로고
    • Wide variability in the sensitivity of APTT reagents for monitoring of heparin dosage
    • Kitchen S, Jennings I, Woods TA, Preston FE. Wide variability in the sensitivity of APTT reagents for monitoring of heparin dosage. J Clin Pathol. 1996;49:10-14.
    • (1996) J Clin Pathol , vol.49 , pp. 10-14
    • Kitchen, S.1    Jennings, I.2    Woods, T.A.3    Preston, F.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.