Preparation and characterization of bFGF and BSA-loaded microspheres

Journal of Drug Delivery Science and Technology

Volumn 15, Issue 5, 2005, Pages 371-375

  Cetin, M ^a   Capan, Y ^a   Vural, I ^a   Dogan, A L ^a   Guc, D ^a   Hincal, A A ^a   Wehrle P ^b   Dalkara, T ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

bFGF; BSA; Microspheres; PLGA; SDS PAGE

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; BOVINE SERUM ALBUMIN; HEPARIN; MICROSPHERE; POLYGLACTIN;

ANIMAL CELL; ARTICLE; BIOTECHNOLOGICAL PROCEDURES; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; EMULSION; EVALUATION; IN VITRO STUDY; MICROENCAPSULATION; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN SYNTHESIS;

EID: 26244447109     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1773-2247(05)50067-4     Document Type: Article

References (25)

1. VILA A., SÁNCHES A., TOBÍO M., CALVO P., ALONSO M.J. - Design of biodegradable particles for protein delivery. - J. Control. Release, 78, 15-24, 2002.
2. BABENSEE J. E., McINTIRE L.V., MIKOS A.G. - Growth factor delivery for tissue engineering. - Pharm. Res., 17 (5), 497-504, 2000.
3. AUBERT-POUËSSEL A., BIBBY D.C., VENIER-JULIENNE M., HINDRÉ F., BENOIT J. - A novel in vitro delivery system for assessing the biological integrity of protein upon release from PLGA microspheres. - Pharm. Res., 19 (7), 1046-1051, 2002.
4. TABATA Y., IKATA Y. - Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities. - Biomaterials, 20, 2169-2175, 1999.
5. DELRIEU I. - The high molecular weight isoforms of basic fibroblast growth factor (FGF-2): an insight into an intracrine mechanism. - FEBS Letters, 468, 6-10, 2000.
6. GOSPODAROWICZ D., CHENG J. - Heparin protects basic and acidic FGF from inactivation. - J. Cell Physiol., 128, 475-484, 1986.
7. SONG B.W., VINTERS H.V., WU D., PARDRIDGE W.M. - Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector. - J. Pharmacol. Exp. Ther., 301 (2), 605-610, 2002.
8. CUEVAS P., CARCELLER F., MUÑOZ-WILLERY I., GIMÉNEZ-GALLEGO G. - Intravenous fibroblast growth factor penetrates the blood-brain barrier and protects hippocampal neurons against ischemia-reperfusion injury. - Surg. Neurol., 49, 77-84, 1998.
9. ZHU H., RAMNARAYAN K., ANCHIN J., MIAO W.Y., SERENO A., MILLMAN L., ZHENG J., BALAJI V. N., WOLFF M. E. - Glu-96 of basic fibroblast growth factoris essential for high affinity receptor binding. - J. Biol. Chem., 270 (37), 21869-21874, 1995.
10. LEMOINE D., PRÉAT V. - Polymeric nanoparticles as delivery system for influenza virus glycoproteins. - J. Control. Release, 54, 15-27, 1998.
11. CETIN M., CAPAN Y., VURAL I., SARGON M. F., HINCAL A. A., WEHRLÉ P. - The preparation and characterization of poly(lactide-co-glycolide) microspheres as protein carriers. - AAPS, Annual Meeting and Exposition, Utah, 26-30 October 2003, AAPS PharmSci., 5 (4), Abstract T3219.
12. CAPAN Y., JIANG G., GIOVAGNOLI S., NA K. H., DELUCA P. P. - Preparation and characterization of poly(D,L-lactide-co-glycolide) microspheres for controlled release of human growth hormone. - AAPS Pharm. Sci. Tech., 4 (2), 236-245, 2003.
13. ZHU G., MALLERY S.R., SCHWENDEMAN S.P. - Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide). - Nat. Biotechnol., 18, 52-57, 2000.
14. LAEMMLI U. K. - Cleavage of structural proteins during the resembly of the head of bacteriophage T4. - Nature, 227, 680-685, 1970.
15. NIHANT N., SCHUGENS C., GRANDFILS C., JEROME R., TEYSSIE P. - Polylactide microspheres prepared by double emulsion/evaporation technique. I. Effect of primary emulsion stability.- Pharm. Res., 11 (10), 1479-1484, 1994.
16. NIWA T., TAKEUCHI H., HINO T., KUNOU N., KAWASHIMA Y. - Preparations of biodegradable nanospheres of water soluble and insoluble drugs with D,L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior. - J. Control. Release, 25, 89-98, 1993.
17. SCHOLES P.D., COOMBES A.G.A., ILLUM L., DAVIS S.S., VERT M., DAVIES M.C. - The preparation of sub-200 nm poly(lactide-co-glycolide) microspheres for site-spesific drug delivery. - J. Control. Release, 25, 145-153, 1993.
18. VANDERVOORT J., LUDWIG A. - Biocompatible stabilizers in the preparation of PLGA nanoparticles: a factorial design study. - Int. J. Pharm., 238, 77-92, 2002.
19. HERRMANN J., BODMEIER R. - The effect of particle microstructure on the somatostatin release from poly (lactide) microspheres prepared by a w/o/w solvent evaporation method. - J. Control. Release, 36, 63-71, 1995.
20. LEE W.K., PARK J.Y., YANG E.H., SUH H., KIM S.H., CHUNG D.S., CHOI K., YANG C.W., PARK J.S. - Investigation of the factors influencing the release rates of cyclosporin A-loaded micro- and nanoparticles prepared by high pressure homogenizer. - J. Control. Release, 84, 115-123, 2002.
21. BLANCO M. D., ALONSO M. J. - Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres. - Eur. J. Pharm. Biopharm., 43, 287-294, 1997.
22. CELEBRI N., HAZRATI A.M., LEE K.C., MEHTA R.C., CARLI F., DELUCA P. P. - Interaction of salmon calcitonin with hydrophobic biodegradable polymers. - Proc. Int. Symp. Control. Release Bioact. Mater., 17, 461-462, 1990.
23. BLANCO D., ALONSO M.J. - Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants. - Eur. J. Pharm. Biopharm., 45, 285-294, 1998.
24. SAHOO S. K., PANYAM J., PRABHA S., LABHASETWAR V. - Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. - J. Control. Release, 82, 105-114, 2002.
25. NISSEN N.N., SHANKAR R., GAMELLI R.L., SINGH A., DIPIETRO L.A. - Heparin and heparan sulphate protect basic fibroblast growth factor from non-enzymic glycosylation. - Biochem. J., 338, 637-642, 1999.