Biochemical evaluation of the inflammatory changes in cardiac, hepatic and renal tissues of adriamycin-administered rats and the modulatory role of exogenous heparin-derivative treatment

Chemico-Biological Interactions

Volumn 156, Issue 2-3, 2005, Pages 93-100

  Deepa, P R ^a   Varalakshmi, P ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Adriamycin; Cytotoxicity; Heparin; Inflammation; Low molecular weight heparin

Indexed keywords

C REACTIVE PROTEIN; CERTOPARIN; DOXORUBICIN; FIBRINOGEN; HEXOSAMINE; HEXOSE; HEXURONIC ACID; LYSOSOME ENZYME; SIALIC ACID; TROPARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; EVALUATION; HEART; INFLAMMATION; KIDNEY PARENCHYMA; LIVER; MALE; NONHUMAN; RAT;

ACUTE-PHASE REACTION; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; C-REACTIVE PROTEIN; DOXORUBICIN; DRUG THERAPY, COMBINATION; FIBRINOGEN; FIBRINOLYTIC AGENTS; HEART; HEPARIN, LOW-MOLECULAR-WEIGHT; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; KIDNEY; LIVER; MALE; MYOCARDIUM; RATS; RATS, WISTAR;

RATTUS NORVEGICUS;

EID: 26044462195     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.07.008     Document Type: Article

References (41)

1. A. Guezmes, F. Fernandez, F. Garijo, and F. Val-Bernal Correlation between tubulointerstitial nephropathy and glomerular lesions induced by adriamycin Nephron 62 1992 198 202
2. S.Y. Saad, T.A. Najjar, and A.C. Al-Rikabi The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats Pharmacol. Res. 43 2001 211 218
3. 60 gamma-rays Radiat. Environ. Biophys. 22 1983 281 291
4. M.R. Flick, J.M. Hoeffel, and N.C. Staub Superoxide dismutase with heparin prevents increased lung vascular permeability during air emboli in sheep J. Appl. Physiol. 55 1983 1284 1291
5. P.R. Deepa, and P. Varalakshmi Protective effect of low molecular weight heparin on oxidative injury and cellular abnormalities in adriamycin-induced cardiac and hepatic toxicity Chem. Biol. Interact. 146 2 2003 201 210
6. P.R. Deepa, and P. Varalakshmi The cytoprotective role of a low-molecular-weight heparin fragment studied in an experimental model of glomerulotoxicity Eur. J. Pharmacol. 478 2-3 2003 199 205
7. D.J. Tyrrell, A.P. Horne, K.R. Holme, J.M. Preuss, and C.P. Page Heparin in inflammation: potential therapeutic applications beyond anticoagulation Adv. Pharmacol. 46 1999 151 208
8. L. Cahalon, O. Lider, H. Schor, A. Avron, D. Gilat, R. Hershkoviz, R. Margalit, A. Eshel, O. Shoseyev, and I.R. Cohen Heparin disaccharides inhibit tumor necrosis factor-alpha production by macrophages and arrest immune inflammation in rodents Int. Immunol. 9 1997 1517 1522
9. J. King The hydrolases - acid and alkaline phosphatases D. Van Practical Clinical Enzymology 1965 Nostrand Company Limited London 191 208
10. D. Marhun Rapid colorimetric assay of β-galactosidase and N-acetyl-β-galactosaminidase in human urine Clin. Chim. Acta 73 1976 453 461
11. Y. Kawai, and K. Anno Mucopolysaccharide-degrading enzymes from the liver of the squid, Ommastrephes slaoni pacificus. I. Hyaluronidase Biochim. Biophys. Acta 242 1971 428 436
12. D.J. Etherington The nature of collagenolytic cathepsin of rat liver and its distribution in other rat tissues Biochem. J. 127 1972 685 692
13. P. Niebes Determination of enzymes and degradation products of glycosaminoglycan metabolism in the serum of healthy and varicose subjects Clin. Chim. Acta 42 1972 399 408
14. W.D. Wagner More sensitive assay discriminating galactosamine and glucosamine in mixtures Anal. Biochem. 94 1979 394 397
15. T. Bitter, and H.M. Muir Modified uronic acid - carbazole reaction Anal. Biochem. 4 1962 330 334
16. D. Aminoff Methods for the quantitative estimation of N-acetyl-neuraminic acid and their application to hydrolysates of sialomucoids Biochem. J. 81 1961 384 392
17. H.C. Lempert Determination of plasma protein H. Varley Practical clinical Biochemistry fourth ed. 1969 CBS publishers New Delhi, India 233
18. A. Oronsky, L. Ignarro, and R. Perper Release of cartilage mucopolysaccharide-degrading neutral protease from human leukocytes J. Exp. Med. 138 1973 461 472
19. N. Gebbia, G. Leto, M. Gagliano, F.M. Tumminello, and L. Rausa Lysosomal alterations in heart and liver of mice treated with doxorubicin Cancer Chemother. Pharmacol. 15 1985 26 30
20. G. Weissmann The role of lysosomes in inflammation and disease Annu. Rev. Med. 18 1967 97 112
21. R.M. Nelson, O. Cecconi, W.G. Roberts, A. Aruffo, R.J. Linhardt, and M.P. Bevilacqua Heparin oligosaccharides bind L- and P-Selectin and inhibit acute inflammation Blood 82 1993 3253 3258
22. G.K. Reddy, and S.C. Dhar Studies on carbohydrate moieties of glycoproteins in established adjuvant induced arthritis Agents Actions 25 1988 63 70
23. J.B. Caulfield, and V. Bittner Cardiac matrix alterations induced by adriamycin Am. J. Pathol. 133 1988 298 305
24. D.S. Jackson, and J.P. Bentley BS. Gould Treatise in Collagen 1968 Academic Press London 189 214
25. A.B. Patel, and H. Venkatakrishna-Bhatt Effect of lead on the blood serum, liver and brain sialoglycoconjugate levels in rats Hum. Exp. Toxicol. 11 1992 89 92
26. A.B. Patel, and H. Venkatakrishna-Bhatt Dose related increase in the serum levels of protein bound hexose after acute exposure with cadmium in rats Ind. J. Pharmacol. 25 1993 103 104
27. K. Szprynger, M. Szczepanska, B. Mazur, A. Dyduch, D. Zwolinska, A. Morawiec-Knysak, and I. Makulska Evaluation of serum sialic acid concentration in chronic renal failure children on continuous ambulatory peritoneal dialysis and hemodialysis Pol. Merkuriusz. Lek. 8 2000 459 461
28. B. Afzali, R.S. Bakri, P. Bharma-Ariza, P.J. Lumb, N. Dalton, N.C. Turner, A.S. Wierzbicki, M.A. Crook, and D.J. Goldsmith Raised plasma total sialic acid levels are markers of cardiovascular disease in renal dialysis patients J. Nephrol. 16 2003 540 545
29. A. Poggi, L. Kornblihtt, F. Delaini, T. Colombo, L. Mussoni, I. Reyers, and M.B. Donati Delayed hypercoagulability after a single dose of adriamycin to normal rats Thromb. Res. 16 1979 639 650
30. T. Bertani, A. Poggi, R. Pozzoni, F. Delaini, G. Sacchi, Y. Thoua, G. Mecca, G. Remuzzi, and M.B. Donati Adriamycin - induced nephrotic syndrome in rats: sequence of pathologic events Lab. Invest. 46 1982 16 23
31. L.A. Sechi, L. Zingaro, C. Catena, and S. De Marchi Increased fibrinogen levels and hemostatic abnormalities in patients with arteriolar nephrosclerosis: association with cardiovascular events Thromb. Haemost. 84 2000 565 570
32. S. Tomura, Y. Nakamura, F. Deguchi, R. Ando, Y. Chida, and F. Marumo Coagulation and fibrinolysis in patients with chronic renal failure undergoing conservative treatment Thromb. Res. 64 1991 81 90
33. A. Irish Cardiovascular disease, fibrinogen and the acute phase response: associations with lipids and blood pressure in patients with chronic renal disease Atherosclerosis 137 1998 133 139
34. H. Engelberg Low-dose intermittent heparin therapy decreases plasma fibrinogen levels Semin. Thromb. Haemost. 17 1991 211 215
35. P.R. Deepa, and P. Varalakshmi Protective effects of certoparin sodium, a low molecular weight heparin derivative, in experimental atherosclerosis Clin. Chim. Acta 339 2004 105 115
36. H. Engelberg Actions of heparin in the atherosclerotic process Pharmacol. Rev. 48 1996 327 352
37. W.B. Kannel, P.A. Wolf, W.P. Castelli, and R.B. D'Agostino Fibrinogen and risk of cardiovascular disease. The Framingham Study JAMA 258 1987 1183 1186
38. S. Fichtlscherer, and A.M. Zeiher Endothelial dysfunction in acute coronary syndromes: association with elevated C-reactive protein levels Ann. Med. 32 2000 515 518
39. J.A. Sjoland, R. Smith Pedersen, J. Jespersen, and J. Gram Intraperitoneal heparin reduces peritoneal permeability and increases ultrafiltration in peritoneal dialysis patients Nephrol. Dial. Transplant. 19 5 2004 1264 1268
40. A. Salas, M. Sans, A. Soriano, J.C. Reverter, D.C. Anderson, J.M. Pique, and J. Panes Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism Gut 47 1 2000 88 96
41. B. Xia, H. Han, K.J. Zhang, J. Li, G.S. Guo, L.L. Gong, X.C. Zeng, and J.Y. Liu Effects of low molecular weight heparin on platelet surface P-selectin expression and serum interleukin-8 production in rats with trinitrobenzene sulphonic acid-induced colitis World J. Gastroenterol. 10 5 2004 729 732