Acute myeloid leukemia treatment in patients over 60 years of age. Comparison of symptomatic, palliative, and aggressive therapy

Neoplasma

Volumn 52, Issue 5, 2005, Pages 411-414

  Doubek, M ^a   Palasek, I ^a   Brychtova, Y ^a   Buchtova, I ^a   Mayer, J ^a  

^a UNIVERSITY HOSPITAL BRNO   (Czech Republic)

Author keywords

Acute myeloid leukemia; Elderly; Survival; Treatment

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER PALLIATIVE THERAPY; CANCER SURVIVAL; ELDERLY CARE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; QUALITY OF LIFE; SURVIVAL TIME;

EID: 26044449815     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. BEHRINGER B, PITAKO JA, KUNZMANN R, SCHMOOR C, BEHRINGER D et al. Prognosis of older patients with acute myeloid leukemia receiving either induction or noncurative treatment: a single-center retrospective study. Ann Hematol 2003; 82: 381-389.
2. BRINCKER H. Population-based age- and sex-specific incidence rates in the 4 main types of leukaemia. Scand J Haematol 1982; 29: 241-249.
3. DALLEY CD, LILLINGTON DL, BRADBURN M, CARTER M, AMESS JA et al. Acute myelogenous leukaemia in older patients at St Bartholomew's Hospital: outcome with mitoxantrone and cytarabine. Hematol J 2002; 3: 237-243.
4. DETOURMIGNIES L, WATTELE, LAI, BAUTERS F, PENAUX P. Is there still a role for low-dose cytosine arabinoside in de novo acute myeloid leukemia in the elderly? Ann Hematol 1993; 66: 235-240.
5. FELDMAN EJ, SEITER K, DAMON L, LINKER C, RUGO H et al. A randomized trial of high- vs standard-dose mitoxantrone with cytarabine in elderly patients with acute myeloid leukemia. Leukemia 1997; 11: 485-489.
6. GRIMWADE D, WALKER H, OLIVER F, WHEATLEY K, HARRISON C et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 1998; 92: 2322-2333.
7. HIDDEMANN W, KERN W, SCHOCH C, FONATSCH C, HEINECKE A et al. Management of acute myeloid leukemia in elderly patients. J Clin Oncol 1999; 17: 3569-3576.
8. JACKSON GH, TAYLOR PR, IQBAL A, GALLOWAY MJ, TURNER G et al. The use of an oral chemotherapy (idarubicin and etoposide) in treatment of acute myeloid leukaemia in the elderly: a report of toxicity and efficacy. Leukemia 1997; 11: 1193-1196.
9. LARSON RA. Current use and future development of gentuzumab ozogamicin. Semin Hematol 2001; 38 Suppl 6: 24-31.
10. LEITH CP, KOPECKY KJ, GODWIN J, McCONNELL T, SLOVAK ML et al. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetic distinguishes biologic subgroups with remarkably distinct response to standard chemotherapy. A Southwest Oncology Group study. Blood 1997; 89: 3323-3329.
11. LOPEZ A, DE LA RUBIA J, MARTIN G, MARTINEZ J, CERVERA J et al. Recent improvements in outcome for elderly patients with de novo acute myeloblastic leukaemia. Leukemia Res 2001; 25: 685-692.
12. LÖWENBERG B. Treatment of the elderly patient with acute myeloid leukemia. Balliers Clin Hematol 1996; 9: 147-159.
13. LÖWENBERG B, DOWNING JR, BURNETT A. Acute myeloid leukemia. N Engl J Med 1999; 341: 1051-1062.
14. LÖWENBERG B, SUCIU S, ARCHIMBAUD E, OSSENKOPPELE G, VERHOEF GE et al. Use of recombinant granulocyte-macrophage colony-stimulating factor during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia (AML): final report of AML-11. Blood 1997; 90: 2952-2961.
15. LÖWENBERG B, ZITTOUN R, KERKHOFS H, JEHN U, ABELS J et al. On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: a randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group. J Clin Oncol 1989; 7: 1268-1274.
16. MACCALLUM PK, ROHATINER AZ, DAVIS CL, WHELAN JS, OZA AM et al. Mitoxantrone and cytosine arabinoside as treatment for acute myeloblastic leukaemia in older patients. Ann Hematol 1995; 71: 35-39.
17. PULSONI A, PAGANO L, LATAGLIATA R, CASINI M, CERRI R et al. Survival of elderly patients with acute myeloid leukaemia. Haematologica 2004; 89: 296-302.
18. STASIR, VENDITTI A, DEL POETA G, ARONICA G, DENTAMARO T et al. Intensive treatment of patients age 60 and older with de novo acute myeloid leukaemia. Analysis of prognostic factors. Cancer 1996; 77: 2476-2488.
19. TAYLOR PR, REID MM, STARK AN, BOWN N, HAMILTON PJ, PROCTOR SJ. De-novo acute myeloid leukaemia in patients over 55 years old. Leukemia 1995; 23: 231-237.
20. WAHLIN A, MARKEVARN B, GOLOVLEVA I, NILSSON M. Prognostic significance of risk group stratification in elderly patients with acute myeloid leukaemia. Br J Haematol 2001; 115:25-33.
21. WEDDING U, BOKEMEYER C, MERAN JG. Elderly patients with acute myeloid leukaemia: characteristics in biology, patients and treatment. Onkologie 2004; 27: 72-82.