Combinatorial discovery of new asymmetric cis platinum anticancer complexes is made possible with solid-phase synthetic methods

Journal of Inorganic Biochemistry

Volumn 99, Issue 10, 2005, Pages 2032-2038

  Van Zutphen, Steven ^a   Stone, Elizabeth A ^a   Van Rijt, Sabine ^a   Robillard, Marc S ^a   Van Der Marel, Gijs A ^a   Overkleeft, Herman S ^a   Den Dulk, Hans ^a   Brouwer, Jaap ^a   Reedijk, Jan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Asymmetric platinum complexes; Cisplatin; Combinatorial chemistry; Cytotoxicity; Solid phase synthesis

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CISPLATIN DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASYMMETRIC SYNTHESIS; COMBINATORIAL CHEMISTRY; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; OVARY CARCINOMA; SOLID PHASE SYNTHESIS;

CISPLATIN; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PLATINUM COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 26044432821     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2005.06.033     Document Type: Article

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