Role of 5′-nucleotidase in thiopurine metabolism: Enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment

Clinica Chimica Acta

Volumn 361, Issue 1, 2005, Pages 95-103

  Brouwer, Connie ^a   Vogels Mentink, Trude M ^a   Keizer Garritsen, Jenneke J ^a   Trijbels, Frans J M ^a   Bökkerink, Jos P M ^a,b   Hoogerbrugge, Peter M ^a,b   Van Wering, Elisabeth R ^b   Veerman, Anjo J P ^b   De Abreu, Ronney A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b DUTCH CHILDHOOD ONCOLOGY GROUP   (Netherlands)

Author keywords

5 Nucleotidase; 6 Thiopurines; Acute lymphoblastic leukemia; Substrate specificity

Indexed keywords

5' NUCLEOTIDASE; 6 MERCAPTOPURINE DERIVATIVE; 6 METHYLTHIOINOSINE; 6 THIOINOSINE MONOPHOSPHATE; ASPARAGINASE; DEXAMETHASONE; MERCAPTOPURINE; METHOTREXATE; METHYL 6 THIOINOSINE MONOPHOSPHATE; METHYLTHIOINOSINE MONOPHOSPHATE; PARONAL; PURINE; THIOGUANINE DERIVATIVE; THIOGUANOSINE PHOSPHATE; UNCLASSIFIED DRUG; VINCRISTINE; GUANOSINE PHOSPHATE; THIOL DERIVATIVE; TIOGUANINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BINDING AFFINITY; CHILD; DRUG EFFICACY; DRUG METABOLISM; DRUG SAFETY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; HUMAN; LYMPHOCYTE; MONONUCLEAR CELL; PH; PRIORITY JOURNAL; ACUTE LYMPHOCYTIC LEUKEMIA; BLOOD; CHEMISTRY; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METABOLISM;

5'-GUANYLIC ACID; 5'-NUCLEOTIDASE; 6-MERCAPTOPURINE; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LEUKEMIA, LYMPHOCYTIC, ACUTE; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; THIOGUANINE;

EID: 25844503464     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cccn.2005.05.006     Document Type: Article

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