A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 22, 2005, Pages 4989-4993

  Goodacre, Caroline J ^a   Bromidge, Steven M ^a   Clapham, David ^a   King, Frank D ^a   Lovell, Peter J ^a   Allen, Mike ^a   Campbell, Lorraine P ^a   Holland, Vicky ^a   Riley, Graham J ^a   Starr, Kathryn R ^a   Trail, Brenda K ^a   Wood, Martyn D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT2C receptor antagonists

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 3 (3 FLUOROPHENYL) 1 [4 METHOXY 3 (2 PIPERIDIN 1 YLETHOXY)]IMIDAZOLIDINE 2,4 DIONE; HYDANTOIN DERIVATIVE; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C ANTAGONIST; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CELL LINE; HUMANS; IMIDAZOLIDINES; MOLECULAR STRUCTURE; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

RODENTIA;

EID: 25844497495     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.004     Document Type: Article

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