Specific interactions of mouse organ proteins with the 5′untranslated region of coxsackievirus B3: Potential determinants of viral tissue tropism

Journal of Medical Virology

Volumn 77, Issue 3, 2005, Pages 414-424

  Cheung, Paul Kim Ming ^a   Yuan, Ji ^a   Zhang, Huifang M ^a   Chau, David ^a   Yanagawa, Bobby ^a   Suarez, Agripina ^a   McManus, Bruce ^a   Yang, Decheng ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ST PAUL S HOSPITAL   (Canada)

Author keywords

5 untranslated region; Coxsackievirus B3; Protein RNA interactions; Tissue tropism

Indexed keywords

ALKALINE PHOSPHATASE; CELL PROTEIN; MESSENGER RNA; NUCLEOTIDE; PROTEIN; VIRUS RECEPTOR; VIRUS RNA;

5' UNTRANSLATED REGION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; COXSACKIE VIRUS B3; CROSS LINKING; ENZYME ACTIVITY; HEART; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; INFECTION RESISTANCE; INTERNAL RIBOSOME ENTRY SITE; KIDNEY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PROTEIN RNA BINDING; VIRUS INFECTION; VIRUS REPLICATION;

5' UNTRANSLATED REGIONS; AGE FACTORS; ANIMALS; COXSACKIEVIRUS INFECTIONS; ENTEROVIRUS B, HUMAN; IN SITU HYBRIDIZATION; MICE; ORGAN SPECIFICITY; RNA, VIRAL; RNA-BINDING PROTEINS;

ADENOVIRIDAE; COXSACKIEVIRUS;

EID: 25844456576     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.20470     Document Type: Article

References (40)

1. Anderson DR, Wilson JE, Carthy CM, Yang D, Kandolf R, McManus BM. 1996. Direct interactions of coxsackievirus B3 with immune cells in the splenic compartment of mice susceptible or resistant to myocarditis. J Virol 70:4632-4645.
2. Anderson DR, Carthy CM, Wilson JE, Yang D, Devine DV, McManus BM. 1997. Complement component 3 interactions with coxsackievirus B3 capsid proteins: Innate immunity and the rapid formation of splenic antiviral germinal centers. J Virol 71:8841-8845.
3. Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW. 1997. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320-1323.
4. Bergelson JM, Krithivas A, Celi L, Droguett G, Horwitz MS, Wickham T, Crowell RL, Finberg RW. 1998. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J Virol 72:415-419.
5. Bowles NE, Richardson PJ, Olsen EG, Archard LC. 1986. Detection of Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lancet 1:1120-1123.
6. Carson SD, Chapman NN, Tracy SM. 1997. Purification of the putative coxsackievirus B receptor from HeLa cells. Biochem Biophys Res Commun 233:325-328.
7. Carthy CM, Yang D, Anderson DR, Wilson JE, McManus BM. 1997. Myocarditis as systemic disease: New perspectives on pathogenesis. Clin Exp Pharmacol Physiol 24:997-1003.
8. Carthy CM, Yanagawa B, Luo H, Granville DJ, Yang D, Cheung P, Cheung C, Esfandiarei M, Rudin CM, Thompson CB, Hunt DW, McManus BM. 2003. Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection. Virology 313:147-157.
9. Chapman NM, Romero JR, Pallansch MA, Tracy S. 1997. Sites other than nucleotide 234 determine cardiovirulence in natural isolates of coxsackievirus B3. J Med Virol 52:258-261.
10. Chapman NM, Ragland A, Leser JS, Hofling K, Willian S, Semler BL, Tracy S. 2000. Agroup B coxsackievirus/poliovirus 5′ nontranslated region chimera can act as an attenuated vaccine strain in mice. J Virol 74:4047-4056.
11. Cheung P, Yanagawa B, Zhang H, Wang A, Luo H, Esfandiarei M, Saurez A, Wilson J, Carthy C, McManus B, Yang B. 2001. Molecular mechanisms of cardiovirulence and host cell responses in Coxsackievirus B3 induced Myocarditis. Recent Res Dev Virol 3: 427-454.
12. Cheung P, Zhang M, Yuan J, Chau D, Yanagawa B, McManus B, Yang D. 2002. Specific interactions of HeLa cell proteins with Coxsackievirus B3 RNA: La autoantigen binds differentially to multiple sites within the 5′ untranslated region. Virus Res 90:23-36.
13. D'Ambrosio A, Patti G, Manzoli A, Sinagra G, Di Lenarda A, Silvestri F, Di Sciascio G. 2001. The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy: A review. Heart 85:499-504.
14. Dunn JJ, Chapman NM, Tracy S, Romero JR. 2000. Genomic determinants of cardiovirulence in coxsackievirus B3 clinical isolates: Localization to the 5′ nontranslated region. J Virol 74: 4787-4794.
15. Dunn JJ, Bradrick SS, Chapman NM, Tracy SM, Romero JR. 2003. The stem loop II within the 5′ nontranslated region of clinical coxsackievirus B3 genomes determines cardiovirulence phenotype in a murine model. J Infect Dis 187:1552-1561.
16. Godman GC, Bunting H, Melnick JL. 1952. The histopathology of Coxsackie virus infection in mice. I. Morphologic observations with four different viral types. Am J Pathol 28:223-257.
17. Gottlieb E, Steitz JA. 1989. Function of the mammalian La protein: Evidence for its action in transcription termination by RNA polymerase III. Embo J 8:851-861.
18. Grist NR, Reid D. 1993. Epidemiology of viral infections of the heart. JEB JE, editor. London: Hodder and Stoughton Ltd. pp 23-30.
19. He Y, Chipman PR, Howitt J, Bator CM, Whitt MA, Baker TS, Kuhn RJ, Anderson CW, Freimuth P, Rossmann MG. 2001. Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor. Nat Struct Biol 8:874-878.
20. Hunt SL, Jackson RJ. 1999. Polypyrimidine-tract binding protein (PTB) is necessary, but not sufficient, for efficient internal initiation of translation of human rhinovirus-2 RNA. Rna 5:344-359.
21. Kaminski A, Jackson RJ. 1998. The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute. Rna 4:626-638.
22. Kauder SE, Racaniello VR. 2004. Poliovirus tropism and attenuation are determined after internal ribosome entry. J Clin Invest 113: 1743-1753.
23. Klump WM, Bergmann I, Muller BC, Ameis D, Kandolf R. 1990. Complete nucleotide sequence of infectious Coxsackievirus B3 cDNA: Two initial 5′ uridine residues are regained during plus-strand RNA synthesis. J Virol 64:1573-1583.
24. Lee C, Maull E, Chapman N, Tracy S, Wood J, Gauntt C. 1997. Generation of an infectious cDNA of a highly cardiovirulent coxsackievirus B3(CVB3m) and comparison to other infectious CVB3 cDNAs. Virus Res 50:225-235.
25. Lillevali K, Kulla A, Ord T. 2001. Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain. Mech Dev 101:217-220.
26. Liu PP, Mason JW. 2001. Advances in the understanding of myocarditis. Circulation 104:1076-1082.
27. Liu Z, Carthy CM, Cheung P, Bohunek L, Wilson JE, McManus BM, Yang D. 1999. Structural and functional analysis of the 5′ untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants. Virology 265:206-217.
28. Melnick JL. 1996. Enteroviruses: Poliovirus, coxsacvkieciruses, echoviruses, and newer enteroviruses. In: Virology KDHP. Fields BN, editors. Philadelphia: Lippincott-Raven. pp 655-712.
29. Mena I, Fischer C, Gebhard JR, Perry CM, Harkins S, Whitton JL. 2000. Coxsackievirus infection of the pancreas: Evaluation of receptor expression, pathogenesis, and immunopathology. Virology 271:276-288.
30. Orthopoulos G, Triantafilou K, Triantafilou M. 2004. Coxsackie B viruses use multiple receptors to infect human cardiac cells. J Med Virol 74:291-299.
31. Powell RM, Ward T, Goodfellow I, Almond JW, Evans DJ. 1999. Mapping the binding domains on decay accelerating factor (DAF) for haemagglutinating enteroviruses: Implications for the evolution of a DAF-binding phenotype. J Gen Virol 80:3145-3152.
32. Rohll JB, Percy N, Ley R, Evans DJ, Almond JW, Barclay WS. 1994. The 5′-untranslated regions of picornavirus RNAs contain independent functional domains essential for RNA replication and translation. J Virol 68:4384-4391.
33. Spiller OB, Goodfellow IG, Evans DJ, Hinchliffe SJ, Morgan BP. 2002. Coxsackie B viruses that use human DAF as a receptor infect pig cells via pig CAR and do not use pig DAF. J Gen Virol 83: 45-52.
34. Tomko RP, Xu R, Philipson L. 1997. HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci USA 94:3352-3356.
35. Tracy S, Chapman NM, Tu Z. 1992. Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice. Arch Virol 122:399-409.
36. Tu Z, Chapman NM, Hufnagel G, Tracy S, Romero JR, Barry WH, Zhao L, Currey K, Shapiro B. 1995. The cardiovirulent phenotype of coxsackievirus B3 is determined at a single site in the genomic 5′ nontranslated region. J Virol 69:4607-4618.
37. Wang A, Cheung PK, Zhang H, Carthy CM, Bohunek L, Wilson JE, McManus BM, Yang D. 2001. Specific inhibition of coxsackievirus B3 translation and replication by phosphorothioate antisense oligodeoxynucleotides. Antimicrob Agents Chemother 45:1043-1052.
38. Wessely R, Klingel K, Santana LF, Dalton N, Hongo M, Jonathan Lederer W, Kandolf R, Knowlton KU. 1998. Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy. J Clin Invest 102:1444-1453.
39. Yang D, Wilson JE, Anderson DR, Bohunek L, Cordeiro C, Kandolf R, McManus BM. 1997. In vitro mutational and inhibitory analysis of the cis-acting translational elements within the 5′ untranslated region of coxsackievirus B3: Potential targets for antiviral action of antisense oligomers. Virology 228:63-73.
40. Yang D, Cheung P, Sun Y, Yuan J, Zhang H, Carthy CM, Anderson DR, Bohunek L, Wilson JE, McManus BM. 2003. A shine-dalgarno-like sequence mediates in vitro ribosomal internal entry and subsequent scanning for translation initiation of coxsackievirus B3 RNA. Virology 305:31-43.