메뉴 건너뛰기




Volumn 50, Issue 2, 1997, Pages 225-235

Generation of an infectious cDNA of a highly cardiovirulent coxsackievirus B3(CVB3(m)) and comparison to other infectious CVB3 CDNAs

Author keywords

Cardiovirulence; cDNA cloning; Coxsackievirus B3; Molecular evolution; RNA editing; Selective pressure

Indexed keywords

COMPLEMENTARY DNA; EPITOPE; MONOCLONAL ANTIBODY; VIRUS DNA; VIRUS RNA;

EID: 0030869507     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(97)00059-2     Document Type: Article
Times cited : (21)

References (50)
  • 1
    • 0025932288 scopus 로고
    • The 5′-untranslated region of picornaviral genomes
    • Agol, V.L., 1991. The 5′-untranslated region of picornaviral genomes. Adv. Virus Res. 40, 103-180.
    • (1991) Adv. Virus Res. , vol.40 , pp. 103-180
    • Agol, V.L.1
  • 2
    • 0023488990 scopus 로고
    • The attenuation of poliovirus neurovirulence
    • Almond, J.W., 1987. The attenuation of poliovirus neurovirulence. Ann. Rev. Microbiol. 41, 153-180.
    • (1987) Ann. Rev. Microbiol. , vol.41 , pp. 153-180
    • Almond, J.W.1
  • 3
    • 0025266637 scopus 로고
    • Analysis of the structure of a common cold virus, human rhinovirus 14, refined at a resolution of 3.0 Å
    • Arnold, E., Rossman, M.G., 1990. Analysis of the structure of a common cold virus, human rhinovirus 14, refined at a resolution of 3.0 Å. J. Mol. Biol. 211, 763-801.
    • (1990) J. Mol. Biol. , vol.211 , pp. 763-801
    • Arnold, E.1    Rossman, M.G.2
  • 4
    • 0028365159 scopus 로고
    • Increased virulence of a human enterovirus (coxsackievirus B3) in selenium-deficient mice
    • Beck, M.A., Kolbeck, P.C., Rohr, L.H., Shi, Q., Morris, V.C., Levander, O.A., 1994a. Increased virulence of a human enterovirus (coxsackievirus B3) in selenium-deficient mice. J. Infect. Dis. 170, 351-357.
    • (1994) J. Infect. Dis. , vol.170 , pp. 351-357
    • Beck, M.A.1    Kolbeck, P.C.2    Rohr, L.H.3    Shi, Q.4    Morris, V.C.5    Levander, O.A.6
  • 5
    • 0028330002 scopus 로고
    • Vitamin e deficiency intensifies the myocardial injury of coxsackievirus B3 infection of mice
    • Beck, M.A., Kolbeck, P.C., Rohr, L.H., Shi, Q., Morris, V.C., Levander, O.A., 1994b. Vitamin E deficiency intensifies the myocardial injury of coxsackievirus B3 infection of mice. J. Nutr. 124, 345-358.
    • (1994) J. Nutr. , vol.124 , pp. 345-358
    • Beck, M.A.1    Kolbeck, P.C.2    Rohr, L.H.3    Shi, Q.4    Morris, V.C.5    Levander, O.A.6
  • 6
    • 0029029689 scopus 로고
    • Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates
    • Beck, M.A., Shi, Q., Morris, V.C., Levander, O.A., 1995. Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates. Nat. Med. 1, 433-436.
    • (1995) Nat. Med. , vol.1 , pp. 433-436
    • Beck, M.A.1    Shi, Q.2    Morris, V.C.3    Levander, O.A.4
  • 7
    • 0025996634 scopus 로고
    • Identification of a putative shared epitope between coxsackievirus B4 and α cardiac myosin heavy chain
    • Beisel, K.W., Srinivasappa, J., Prabhakar, B.S., 1991. Identification of a putative shared epitope between coxsackievirus B4 and α cardiac myosin heavy chain. Clin. Exp. Immunol. 86, 49-55.
    • (1991) Clin. Exp. Immunol. , vol.86 , pp. 49-55
    • Beisel, K.W.1    Srinivasappa, J.2    Prabhakar, B.S.3
  • 8
    • 0024835345 scopus 로고
    • The nucleotide sequence of coxsackievirus A9; implications for receptor binding and enterovirus classification
    • Chang, K., Auvinen, P., Hyypia, T., Stanway, G., 1989. The nucleotide sequence of coxsackievirus A9; implications for receptor binding and enterovirus classification. J. Gen. Virol. 70, 3269-3280.
    • (1989) J. Gen. Virol. , vol.70 , pp. 3269-3280
    • Chang, K.1    Auvinen, P.2    Hyypia, T.3    Stanway, G.4
  • 9
    • 0028139792 scopus 로고
    • An infectious cDNA copy of the genome of a non-cardiovirulent coxsackievirus B3 strain: Its complete sequence analysis and comparison to the genomes of cardiovirulent coxsackieviruses
    • Chapman, N.M., Tu, Z., Tracy, S., Gauntt, C.J., 1994. An infectious cDNA copy of the genome of a non-cardiovirulent coxsackievirus B3 strain: Its complete sequence analysis and comparison to the genomes of cardiovirulent coxsackieviruses. Arch. Virol. 135, 115-130.
    • (1994) Arch. Virol. , vol.135 , pp. 115-130
    • Chapman, N.M.1    Tu, Z.2    Tracy, S.3    Gauntt, C.J.4
  • 11
    • 0026518288 scopus 로고
    • Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses and human cardiac myosin
    • Cunningham, M.W., Antone, S.M., Gulizia, J.M., McManus, B.M., Fischetti, V.A., Gauntt, C.J., 1992. Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses and human cardiac myosin. Proc. Natl. Acad. Sci. USA 89, 1320-1324.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1320-1324
    • Cunningham, M.W.1    Antone, S.M.2    Gulizia, J.M.3    McManus, B.M.4    Fischetti, V.A.5    Gauntt, C.J.6
  • 12
    • 85058599884 scopus 로고
    • High error rates, population equilibrium and evolution of RNA replication systems
    • Domingo, E., Holland, J.J., Ahlquist, P. (Eds.), CRC, Boca Raton, FL
    • Domingo, E., Holland, J.J., 1988. High error rates, population equilibrium and evolution of RNA replication systems. In: Domingo, E., Holland, J.J., Ahlquist, P. (Eds.), RNA Genetic vol. 3, CRC, Boca Raton, FL, pp. 3-36.
    • (1988) RNA Genetic , vol.3 , pp. 3-36
    • Domingo, E.1    Holland, J.J.2
  • 13
    • 0025570214 scopus 로고
    • RNA virus quasispecies populations can suppress vastly superior mutant progeny
    • De la Torre, J.C., Holland, J.J., 1990. RNA virus quasispecies populations can suppress vastly superior mutant progeny. J. Virol. 64, 6278-6281.
    • (1990) J. Virol. , vol.64 , pp. 6278-6281
    • De La Torre, J.C.1    Holland, J.J.2
  • 14
    • 0018342066 scopus 로고
    • Properties of coxsackievirus B3 variants which are amyocarditic or myocarditic for mice
    • Gauntt, C.J., Trousdale, M.D., LaBadie, D.R.L., Paque, R.E., Nealon, T., 1979. Properties of coxsackievirus B3 variants which are amyocarditic or myocarditic for mice. J. Med. Virol. 3, 207-220.
    • (1979) J. Med. Virol. , vol.3 , pp. 207-220
    • Gauntt, C.J.1    Trousdale, M.D.2    LaBadie, D.R.L.3    Paque, R.E.4    Nealon, T.5
  • 15
    • 0343771098 scopus 로고
    • The possible role of viral variants in pathogenesis
    • Bendinelli, M., Friedman, H. (Eds.), Plenum Press, New York
    • Gauntt, C.J., 1988. The possible role of viral variants in pathogenesis. In: Bendinelli, M., Friedman, H. (Eds.), Coxsackieviruses-A. General Update. Plenum Press, New York, pp. 159-179.
    • (1988) Coxsackieviruses-A. General Update , pp. 159-179
    • Gauntt, C.J.1
  • 17
    • 0027336104 scopus 로고
    • What lessons can be learned from animal model studies in viral heart disease?
    • Gauntt, C.J., Higdon, A., Bowers, D., 1993b. What lessons can be learned from animal model studies in viral heart disease?. Scand. J. Infect. Dis. 88 (suppl), 49-65.
    • (1993) Scand. J. Infect. Dis. , vol.88 , Issue.SUPPL. , pp. 49-65
    • Gauntt, C.J.1    Higdon, A.2    Bowers, D.3
  • 18
    • 0028929284 scopus 로고
    • Molecular mimicry, anti-coxsackievirus B3 neutralizing monoclonal antibodies and myocarditis
    • Gauntt, C.J., Arizpe, H.M., Higdon, A.L., Wood, H.J., Bowers, D.E., Rozek, M.M., Crawley, R., 1995. Molecular mimicry, anti-coxsackievirus B3 neutralizing monoclonal antibodies and myocarditis. J. Immunol. 154, 2983-2995.
    • (1995) J. Immunol. , vol.154 , pp. 2983-2995
    • Gauntt, C.J.1    Arizpe, H.M.2    Higdon, A.L.3    Wood, H.J.4    Bowers, D.E.5    Rozek, M.M.6    Crawley, R.7
  • 19
    • 0029870021 scopus 로고    scopus 로고
    • Coxsackievirus B3 clinical isolates and murine myocarditis
    • Gauntt, C.J. Pallansch, M.A., 1996. Coxsackievirus B3 clinical isolates and murine myocarditis. Virus Res. 41, 89-99.
    • (1996) Virus Res. , vol.41 , pp. 89-99
    • Gauntt, C.J.1    Pallansch, M.A.2
  • 20
    • 0022409872 scopus 로고
    • Three dimensional structure of poliovirus at 2.9 Å resolution
    • Hogle, J.M., Filman, D.J., 1985. Three dimensional structure of poliovirus at 2.9 Å resolution. Science 229, 1358-1365.
    • (1985) Science , vol.229 , pp. 1358-1365
    • Hogle, J.M.1    Filman, D.J.2
  • 21
    • 0028301346 scopus 로고
    • Alterations in major histocompatibility complex association of myocarditis induced by coxsackievirus B3 mutants selected with monoclonal antibodies to group a streptococci
    • Huber, S.A., Moraska, A., Cunningham, M.W., 1994. Alterations in major histocompatibility complex association of myocarditis induced by coxsackievirus B3 mutants selected with monoclonal antibodies to group A streptococci. Proc. Natl. Acad. Sci. USA 91, 5543-5547.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5543-5547
    • Huber, S.A.1    Moraska, A.2    Cunningham, M.W.3
  • 22
    • 0023150723 scopus 로고
    • Evolution of poliovirus during an outbreak: Sequential type 3 poliovirus isolates from several persons show shifts of neutralization determinants
    • Huovilainen, A., Hovi, T., Kinnunen, L., Takkinen, K., Ferguson, M., Minor, P.D., 1987. Evolution of poliovirus during an outbreak: Sequential type 3 poliovirus isolates from several persons show shifts of neutralization determinants. J. Gen. Virol. 68, 1373-1378.
    • (1987) J. Gen. Virol. , vol.68 , pp. 1373-1378
    • Huovilainen, A.1    Hovi, T.2    Kinnunen, L.3    Takkinen, K.4    Ferguson, M.5    Minor, P.D.6
  • 23
    • 0023276798 scopus 로고
    • The complete nucleotide sequence of coxsackievirus B4 and its comparison to other members of Picornaviridae
    • Jenkins, O., Booth, J.D., Minor, P.D., Almond, J.W., 1987. The complete nucleotide sequence of coxsackievirus B4 and its comparison to other members of Picornaviridae. J. Gen. Virol. 68, 1835-1848.
    • (1987) J. Gen. Virol. , vol.68 , pp. 1835-1848
    • Jenkins, O.1    Booth, J.D.2    Minor, P.D.3    Almond, J.W.4
  • 24
    • 0019215532 scopus 로고
    • Silent nucleotide substitutions and molecular evolutionary clock
    • Jukes, T.H., 1980. Silent nucleotide substitutions and molecular evolutionary clock. Science 210, 973-978.
    • (1980) Science , vol.210 , pp. 973-978
    • Jukes, T.H.1
  • 25
    • 0041940297 scopus 로고
    • Molecular cloning of the genome of a cardiotropic coxsackie B3 virus: Full-length reverse-transcribed recombinant cDNA generates infectious virus in mammalian cells
    • Kandolf, R., Hofschneider, P.H., 1985. Molecular cloning of the genome of a cardiotropic coxsackie B3 virus: Full-length reverse-transcribed recombinant cDNA generates infectious virus in mammalian cells. Proc. Natl. Acad. Sci. USA 82, 4818-4822.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 4818-4822
    • Kandolf, R.1    Hofschneider, P.H.2
  • 26
    • 0025212682 scopus 로고
    • Complete nucleotide sequence of infectious coxsackievirus B3 cDNA: Two initial 5′ uridine residues are regained during plus-stranded RNA synthesis
    • Klump, W.M., Bergmann, I., Muller, B.C., Ameis, D., Kandolf, R., 1990. Complete nucleotide sequence of infectious coxsackievirus B3 cDNA: Two initial 5′ uridine residues are regained during plus-stranded RNA synthesis. J. Virol. 64, 1573-1583.
    • (1990) J. Virol. , vol.64 , pp. 1573-1583
    • Klump, W.M.1    Bergmann, I.2    Muller, B.C.3    Ameis, D.4    Kandolf, R.5
  • 27
    • 0029843593 scopus 로고    scopus 로고
    • A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3
    • Knowlton, K.U., Jeon, E.-S., Berkley, N., Wessely, R., Huber, S., 1996. A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3. J. Virol. 70, 7811-7818.
    • (1996) J. Virol. , vol.70 , pp. 7811-7818
    • Knowlton, K.U.1    Jeon, E.-S.2    Berkley, N.3    Wessely, R.4    Huber, S.5
  • 28
    • 0027163079 scopus 로고
    • Evolution of hominoid mitochondrial DNA with special reference to the silent substitution rate over the genome
    • Kondo, R., Horai, S., Satta, Y., Takahata, N., 1993. Evolution of hominoid mitochondrial DNA with special reference to the silent substitution rate over the genome. J. Mol. Evol. 36, 517-531.
    • (1993) J. Mol. Evol. , vol.36 , pp. 517-531
    • Kondo, R.1    Horai, S.2    Satta, Y.3    Takahata, N.4
  • 30
    • 12044252669 scopus 로고
    • Cytolytic cross-reactive antibodies directed against the cardiac membrane and viral proteins in coxsackievirus B3 and B4 myocarditis
    • Maisch, B., Bauer, E., Cirsi, M., Kocksiek, K., 1993. Cytolytic cross-reactive antibodies directed against the cardiac membrane and viral proteins in coxsackievirus B3 and B4 myocarditis. Circulation 87 (Suppl IV), 49-65.
    • (1993) Circulation , vol.87 , Issue.4 SUPPL. , pp. 49-65
    • Maisch, B.1    Bauer, E.2    Cirsi, M.3    Kocksiek, K.4
  • 31
    • 0000368147 scopus 로고
    • Enteroviral myocarditis and dilated cardiomyopathy: A review of clinical and experimental studies
    • Rotbart, H.A. (Ed.), American Society for Microbiology, Washington DC
    • Martino, T.A., Liu, P., Petric, M., Sole, M.J., 1995. Enteroviral myocarditis and dilated cardiomyopathy: A review of clinical and experimental studies. In: Rotbart, H.A. (Ed.), Human Enterovirus Infections. American Society for Microbiology, Washington DC, pp. 291-351.
    • (1995) Human Enterovirus Infections , pp. 291-351
    • Martino, T.A.1    Liu, P.2    Petric, M.3    Sole, M.J.4
  • 33
    • 0022550754 scopus 로고
    • Antigenic and molecular evolution of the vaccine strain of type 3 poliovirus during the period of excretion by a primary vaccine
    • Minor, P.D., John, A., Ferguson, M., Icenogle, J.P., 1986. Antigenic and molecular evolution of the vaccine strain of type 3 poliovirus during the period of excretion by a primary vaccine. J. Gen. Virol. 67, 693-706.
    • (1986) J. Gen. Virol. , vol.67 , pp. 693-706
    • Minor, P.D.1    John, A.2    Ferguson, M.3    Icenogle, J.P.4
  • 34
    • 0023930681 scopus 로고
    • The effect of sequence in the 5′ non-coding region on the replication of polioviruses in the human gut
    • Minor, P.D., Dunn, G., 1988. The effect of sequence in the 5′ non-coding region on the replication of polioviruses in the human gut. J. Gen. Virol. 69, 1091-1096.
    • (1988) J. Gen. Virol. , vol.69 , pp. 1091-1096
    • Minor, P.D.1    Dunn, G.2
  • 36
    • 0000371262 scopus 로고
    • Sequence alignments of picornaviral capsid proteins
    • Semler, B.L., Ehrenfeld, E. (Eds.), American Society for Microbiology, Washington DC
    • Palmenberg, A.C., 1989. Sequence alignments of picornaviral capsid proteins, In: Semler, B.L., Ehrenfeld, E. (Eds.), Molecular Aspects of Picornavirus Infection and Detection. American Society for Microbiology, Washington DC, pp. 211-241.
    • (1989) Molecular Aspects of Picornavirus Infection and Detection , pp. 211-241
    • Palmenberg, A.C.1
  • 37
    • 0023799863 scopus 로고
    • Poliovirus neurovirulence
    • Racaniello, V.R., 1988. Poliovirus neurovirulence. Adv. Virus Res. 34, 217-246.
    • (1988) Adv. Virus Res. , vol.34 , pp. 217-246
    • Racaniello, V.R.1
  • 40
    • 0343825307 scopus 로고
    • Identification of a main autoimmunogenic epitope of the adenine nucleotide translocator which crossreacts with coxsackievirus B3: Use in the diagnosis of myocarditis and dilated cardiomyopathy
    • Schwimmbeck, P.L., Schultheiss, H.-P., Strauer, B.E., 1989. Identification of a main autoimmunogenic epitope of the adenine nucleotide translocator which crossreacts with coxsackievirus B3: Use in the diagnosis of myocarditis and dilated cardiomyopathy. Circulation 80 (Suppl II), 665-669.
    • (1989) Circulation , vol.80 , Issue.2 SUPPL. , pp. 665-669
    • Schwimmbeck, P.L.1    Schultheiss, H.-P.2    Strauer, B.E.3
  • 41
    • 0024584249 scopus 로고
    • Extreme heterogeneity in populations of vesicular stomatitis virus
    • Steinhauer, D.A., de la Torre, J.C., Meier, E., Holland, J.J., 1989. Extreme heterogeneity in populations of vesicular stomatitis virus. J. Virol. 63, 2072-2080.
    • (1989) J. Virol. , vol.63 , pp. 2072-2080
    • Steinhauer, D.A.1    De La Torre, J.C.2    Meier, E.3    Holland, J.J.4
  • 42
    • 0029954908 scopus 로고    scopus 로고
    • Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease
    • Tracy, S., Chapman, N.M., Romero, J., Ramsingh, A., 1996. Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease. Trends Microbiol. 4, 175-179.
    • (1996) Trends Microbiol. , vol.4 , pp. 175-179
    • Tracy, S.1    Chapman, N.M.2    Romero, J.3    Ramsingh, A.4
  • 43
    • 0343364418 scopus 로고
    • The genome of the group B coxsackieviruses
    • Bendinelli, M., Herman, F., (Eds.), Plenum Press, New York
    • Tracy, S., 1988. The genome of the group B coxsackieviruses. In: Bendinelli, M., Herman, F., (Eds.), Coxsackievirus. A General Update. Plenum Press, New York, pp. 19-33.
    • (1988) Coxsackievirus. A General Update , pp. 19-33
    • Tracy, S.1
  • 44
    • 0026449946 scopus 로고
    • Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice
    • Tracy, S., Chapman, N.M., Tu, Z., 1992. Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice. Arch. Virol. 122, 399-409.
    • (1992) Arch. Virol. , vol.122 , pp. 399-409
    • Tracy, S.1    Chapman, N.M.2    Tu, Z.3
  • 45
    • 0029037520 scopus 로고
    • The cardiovirulent phenotype of coxsackievirus B3 is determined at a single site in the genomic 5′ non-translated region
    • Tu, Z., Chapman, N.M., Hufnagel, G., Tracy, S., Romero, J.R., Barry, W.H., Zhao, L., Currey, K., Shapiro, B., 1995. The cardiovirulent phenotype of coxsackievirus B3 is determined at a single site in the genomic 5′ non-translated region. J. Virol. 69, 4607-4618.
    • (1995) J. Virol. , vol.69 , pp. 4607-4618
    • Tu, Z.1    Chapman, N.M.2    Hufnagel, G.3    Tracy, S.4    Romero, J.R.5    Barry, W.H.6    Zhao, L.7    Currey, K.8    Shapiro, B.9
  • 46
    • 0026019432 scopus 로고
    • Selection of an attenuated coxsackievirus B3 variant, using a monoclonal antibody reactive to myocyte antigen
    • Van Houten, N., Bouchard, P.E., Moraska, A., Huber, S., 1991. Selection of an attenuated coxsackievirus B3 variant, using a monoclonal antibody reactive to myocyte antigen. J. Virol. 65, 1286-1290.
    • (1991) J. Virol. , vol.65 , pp. 1286-1290
    • Van Houten, N.1    Bouchard, P.E.2    Moraska, A.3    Huber, S.4
  • 47
    • 0017363167 scopus 로고
    • Higher frequencies of transitions among point mutations
    • Vogel, F., Kopun, M., 1977. Higher frequencies of transitions among point mutations. J. Mol. Evol. 9, 159-180.
    • (1977) J. Mol. Evol. , vol.9 , pp. 159-180
    • Vogel, F.1    Kopun, M.2
  • 48
    • 0014734662 scopus 로고
    • The influence of quantitated past weaning undernutrition on coxsackievirus B3 infection of adult mice. I. Viral persistence and increased severity of lesions
    • Woodruff, J.F., Kilbourne, E.D., 1970. The influence of quantitated past weaning undernutrition on coxsackievirus B3 infection of adult mice. I. Viral persistence and increased severity of lesions. J. Infect. Dis. 121, 137-163.
    • (1970) J. Infect. Dis. , vol.121 , pp. 137-163
    • Woodruff, J.F.1    Kilbourne, E.D.2
  • 49
    • 0019201765 scopus 로고
    • Viral myocarditis - A review
    • Woodruff, J.F., 1980. Viral myocarditis - A review. Am. J. Pathol. 101, 427-479.
    • (1980) Am. J. Pathol. , vol.101 , pp. 427-479
    • Woodruff, J.F.1
  • 50
    • 0027368217 scopus 로고
    • Attenuation of a reactivated cardiovirulent coxsackievirus B3: The 5′ nontranslated region does not contain major attenuation determinants
    • Zhang, H.Y., Yousef, G.E., Cunningham, L., Blake, N.W., Ou Yang, X., Bayston, T.A., Kandolf, R., Archard, L.C., 1993. Attenuation of a reactivated cardiovirulent coxsackievirus B3: The 5′ nontranslated region does not contain major attenuation determinants. J. Med. Virol. 41, 129-137.
    • (1993) J. Med. Virol. , vol.41 , pp. 129-137
    • Zhang, H.Y.1    Yousef, G.E.2    Cunningham, L.3    Blake, N.W.4    Ou Yang, X.5    Bayston, T.A.6    Kandolf, R.7    Archard, L.C.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.