Differential expression of function-related antigens on blood monocytes in children with hemolytic uremic syndrome

Journal of Leukocyte Biology

Volumn 78, Issue 4, 2005, Pages 853-861

  Fernández, Gabriela C ^a,d   Ramos, María V ^a   Gómez, Sonia A ^a   Dran, Graciela I ^a   Exeni, Ramón ^b   Alduncin, Marta ^b   Grimoldi, Irene ^b   Vallejo, Graciela ^c   Elias Costa, Christian ^c   Isturiz, Martín A ^a   Palermo, Marina S ^a  

^a ACADEMIA NACIONAL DE MEDICINA   (Argentina)

^b Pediatric Municipal Hospital of San Justo   (Argentina)

^c HOSPITAL DE NIÑOS RICARDO GUTIÉRREZ   (Argentina)

^d INST DE INVEST HEMATOLOGICAS   (Argentina)

Author keywords

CD14; CD16; HLA DR; HUS; TNF

Indexed keywords

CD11B ANTIGEN; CD14 ANTIGEN; CD64 ANTIGEN; FC RECEPTOR; HLA DR ANTIGEN; IMMUNOGLOBULIN G1; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; BLOOD SAMPLING; BLOOD TRANSFUSION; CELL ADHESION; CELL FUNCTION; CELL ISOLATION; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DIALYSIS; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HEMOLYTIC UREMIC SYNDROME; HUMAN; HUMAN CELL; IMMUNITY; INFANT; INFLAMMATION; MALE; MONOCYTE; PATHOGENESIS; PHAGOCYTOSIS; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL;

ANTIGENS, DIFFERENTIATION; CELL COUNT; CHILD, PRESCHOOL; CYTOTOXICITY, IMMUNOLOGIC; FETAL BLOOD; FLOW CYTOMETRY; HEMOLYTIC-UREMIC SYNDROME; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; INFANT; LIPOPOLYSACCHARIDES; MONOCYTES; PHENOTYPE; TUMOR NECROSIS FACTORS;

EID: 25644433580     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0505251     Document Type: Article

References (59)

1. Karmali, M. A., Petric, M., Lim, C., Fleming, P. C., Arbus, G. S., Lior, H. (1985) The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J. Infect. Dis. 151, 775-782.
2. Remuzzi, G., Ruggenenti, P. (1995) The hemolytic uremic syndrome. Kidney Int. 48, 2-19.
3. Paton, J. C., Paton, A. W. (1998) Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections. Clin. Microbiol. Rev. 11, 450-479.
4. Keusch, G. T., Acheson, D. W. (1997) Thrombotic thrombocytopenic purpura associated with Shiga toxins. Semin. Hematol. 34, 106-116.
5. Litauen, C., Proulx, F., Mariscalco, M. M., Robitaille, P., Turgeon, J. P., Orrbine, E., Rowe, P. C., McLaine, P. N., Seidman, E. (1999) Circulating inflammatory cytokine levels in hemolytic uremic syndrome. Pediatr. Nephrol. 13, 840-845.
6. Proulx, F., Turgeon, J. P., Litalien, C., Mariscalco, M. M., Robitaille, P., Seidman, E. (1998) Inflammatory mediators in Escherichia coli O157:H7 hemorrhagic colitis and hemolytic-uremic syndrome. Pediatr. Infect. Dis. J. 17, 899-904.
7. van Setten, P. A., Monnens, L. A., Verstraten, R. G., van den Heuvel, L. P., van Hinsbergh, V. W. (1996) Effects of verocytotoxin-1 on nonadherent human monocytes: binding characteristics, protein synthesis, and induction of cytokine release. Blood 88, 174-183.
8. Palermo, M. S., Alves Rosa, M. F., Van Rooijen, N., Isturiz, M. A. (1999) Depletion of liver and splenic macrophages reduces the lethality of Shiga toxin-2 in a mouse model. Clin. Exp. Immunol. 116, 462-467.
9. Cheadle, W. G. (1993) The human leukocyte antigens and their relationship to infection. Am. J. Surg. 165, 75S-81S.
10. Troelstra, A., Antal-Szalmas, P., de Graaf-Miltenburg, L. A., Weersink, A. J., Verhoef, J., Van Kessel, K. P., Van Strijp, J. A. (1997) Saturable CD14-dependent binding of fluorescein-labeled lipopolysaccharide to human monocytes. Infect. Immun. 65, 2272-2277.
11. Viriyakosol, S., Kirkland, T. N. (1996) The N-terminal half of membrane CD14 is a functional cellular lipopolysaccharide receptor. Infect. Immun. 64, 653-656.
12. Liu, M. K., Herrera-Velit, P., Brownsey, R. W., Reiner, N. E. (1994) CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J. Immunol. 153, 2642-2652.
13. van de Winkel, J. G., Anderson, C. L. (1991) Biology of human immunoglobulin G Fc receptors. J. Leukoc. Biol. 49, 511-524.
14. van de Winkel, J. G., Capel, P. J. (1993) Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. To-day 14, 215-221.
15. Geffner, J. R., Giordano, M., Serebrinsky, G., Isturiz, M. (1987) The role of reactive oxygen intermediates in nonspecific monocyte cytotoxicity induced by immune complexes. Clin. Exp. Immunol. 67, 646-654.
16. Meerschaert, J., Furie, M. B. (1995) The adhesion molecules used by monocytes for migration across endothelium include CD11a/CD18, CD11b/CD18, and VLA-4 on monocytes and ICAM-1, VCAM-1, and other ligands on endothelium. J. Immunol. 154, 4099-4112.
17. Patarroyo, M. (1994) Adhesion molecules mediating recruitment of monocytes to inflamed tissue. Immunobiology 191, 474-477.
18. Ziegler-Heitbrock, H. W. (1996) Heterogeneity of human blood monocytes: the CD14+ CD16+ subpopulation. Immunol. Today 17, 424-428.
19. Ziegler-Heitbrock, H. W., Fingerle, G., Strobel, M., Schraut, W., Stelter, F., Schutt, C., Passlick, B., Pforte, A. (1993) The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages. Eur. J. Immunol. 23, 2053-2058.
20. Ancuta, P., Weiss, L., Haeffner-Cavaillon, N. (2000) CD14+CD16+ + cells derived in vitro from peripheral blood monocytes exhibit phenotypic and functional dendritic cell-like characteristics. Eur. J. Immunol. 30, 1872-1883.
21. Thomas, R., Lipsky, P. E. (1994) Human peripheral blood dendritic cell subsets. Isolation and characterization of precursor and mature antigen-presenting cells. J. Immunol. 153, 4016-4028.
22. Nockher, W. A., Scherberich, J. E. (1998) Expanded CD14+ CD16+ monocyte subpopulation in patients with acute and chronic infections undergoing hemodialysis. Infect. Immun. 66, 2782-2790.
23. Fingerle, G., Pforte, A., Passlick, B., Blumenstein, M., Strobel, M., Ziegler-Heitbrock, H. W. (1993) The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients. Blood 82, 3170-3176.
24. Kawanaka, N., Yamamura, M., Aita, T., Morita, Y., Okamoto, A., Kawashima, M., Iwahashi, M., Ueno, A., Ohmoto, Y., Makino, H. (2002) CD14+,CD16+ blood monocytes and joint inflammation in rheumatoid arthritis. Arthritis Rheum. 46, 2578-2586.
25. Katayama, K., Matsubara, T., Fujiwara, M., Koga, M., Furukawa, S. (2000) CD14+CD16+ monocyte subpopulation in Kawasaki disease. Clin. Exp. Immunol. 121, 566-570.
26. Nockher, W. A., Bergmann, L., Scherberich, J. E. (1994) Increased soluble CD14 serum levels and altered CD14 expression of peripheral blood monocytes in HIV-infected patients. Clin. Exp. Immunol. 98, 369-374.
27. Thieblemont, N., Weiss, L., Sadeghi, H. M., Estcourt, C., Haeffner-Cavaillon, N. (1995) CD141owCD16high: a cytokine-producing monocyte subset which expands during human immunodeficiency virus infection. Eur. J. Immunol. 25, 3418-3424.
28. Blumenstein, M., Boekstegers, P., Fraunberger, P., Andreesen, R., Ziegler-Heitbrock, H. W., Fingerle-Rowson, G. (1997) Cytokine production precedes the expansion of CD14+CD16+ monocytes in human sepsis: a case report of a patient with self-induced septicemia. Shock 8, 73-75.
29. Gianantonio, C. A., Vitacco, M., Mendilaharzu, F., Gallo, G. E., Sojo, E. T. (1973) The hemolytic-uremic syndrome. Nephron 11, 174-192.
30. Boyum, A. (1968) Separation of leukocytes from blood and bone marrow. Introduction. Scand. J. Clin. Lab. Invest. Suppl. 97, 7.
31. Isturiz, M. A., Giordano, M., Serebrinsky, G. P. (1983) Effect of rheumatoid factors and normal human sera on immune complex-Fc γ R interaction. Clin. Exp. Immunol. 54, 225-231.
32. Wang, A. M., Creasey, A. A., Ladner, M. B., Lin, L. S., Strickler, J., Van Arsdell, J. N., Yamamoto, R., Mark, D. F. (1985) Molecular cloning of the complementary DNA for human tumor necrosis factor. Science 228, 149-154.
33. Comber, P. G., Lentz, V., Schreiber, A. D. (1992) Modulation of the transcriptional rate of Fc γ receptor mRNA in human mononuclear phagocytes. Cell. Immunol. 145, 324-338.
34. Passlick, B., Flieger, D., Ziegler-Heitbrock, H. W. (1989) Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 74, 2527-2534.
35. Nockher, W. A., Scherberich, J. E. (1995) Monocyte cell-surface CD14 expression and soluble CD14 antigen in hemodialysis: evidence for chronic exposure to LPS. Kidney Int. 48, 1469-1476.
36. Hiki, N., Berger, D., Prigl, C., Boelke, E., Wiedeck, H., Seidelmann, M., Staib, L., Kaminishi, M., Oohara, T., Beger, H. G. (1998) Endotoxin binding and elimination by monocytes: secretion of soluble CD14 represents an inducible mechanism counteracting reduced expression of membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal hemoglobinuria. Infect. Immun. 66, 1135-1141.
37. Bazil, V., Strominger, J. L. (1991) Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J. Immunol. 147, 1567-1574.
38. Beigier-Bompadre, M., Barrionuevo, P., Alves-Rosa, F., Rubel, C. J., Palermo, M. S., Isturiz, M. A. (2003) The formyl peptide N-formyl-methionyl- leucyl-phenylalanine downregulates the expression of FcγRs in interferon-γ-activated monocytes/macrophages in vitro and in vivo. Scand. J. Immunol. 57, 221-228.
39. Fernandez, G., Gómez, S. A., Rubel, C., Bentancor, L. V., Barrionuevo, P., Alduncin, M., Grimoldi, I., Exeni, R., Isturiz, M. A., Palermo, M. S. (2005) Impaired neutrophils (PMN) in children with the typical form of hemolytic uremic syndrome (D+HUS). Pedlatr. Nephrol., Epub ahead of print.
40. Fernandez, G. C., Rubel, C., Barrionuevo, P., Lopez, L., Ramirez, F., Diaz, M., Isturiz, M. A., Palermo, M. S. (2002) Phenotype markers and function of neutrophils in children with hemolytic uremic syndrome. Pediatr. Nephrol. 17, 337-344.
41. Kaplan, B. S., Mills, M. (1988) Elevated serum elastase and α-1-antitrypsin levels in hemolytic uremic syndrome. Clin. Nephrol. 30, 193-196.
42. Docke, W. D., Randow, F., Syrbe, U., Krausch, D., Asadullah, K., Reinke, P., Volk, H. D., Kox, W. (1997) Monocyte deactivation in septic patients: restoration by IFN-aγ treatment. Nat. Med. 3, 678-681.
43. Wilhelm, W., Grundmann, U., Rensing, H., Werth, M., Langemeyer, J., Stracke, C., Dhingra, D., Bauer, M. (2002) Monocyte deactivation in severe human sepsis or following cardiopulmonary bypass. Shock 17, 354-360.
44. Springer, T. A. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314.
45. Hynes, R. O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
46. Ditschkowski, M., Kreuzfelder, E., Rebmann, V., Ferencik, S., Majetschak, M., Schmid, E. N., Obertacke, U., Hirche, H., Schade, U. F., Grosse-Wilde, H. (1999) HLA-DR expression and soluble HLA-DR levels in septic patients after trauma. Ann. Surg. 229, 246-254.
47. Hershman, M. J., Cheadle, W. G., Wellhausen, S. R., Davidson, P. F., Polk Jr., H. C. (1990) Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br. J. Surg. 77, 204-207.
48. Wakefield, C H., Carey, P. D., Foulds, S., Monson, J. R., Guillou, P. J. (1993) Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br. J. Surg. 80, 205-209.
49. van den Berk, J. M., Oldenburger, R. H., van den Berg, A. P., Klompmaker, I. J., Mesander, G., van Son, W. J., van der Bij, W., Sloof, M. J., The, T. H. (1997) Low HLA-DR expression on monocytes as a prognostic marker for bacterial sepsis after liver transplantation. Transplantation 63, 1846-1848.
50. Skrzeczynska, J., Kobylarz, K., Hartwich, Z., Zembala, M., Pryjma, J. (2002) CD14+CD16+ monocytes in the course of sepsis in neonates and small children: monitoring and functional studies. Scand. J. Immunol. 55, 629-638.
51. Sassetti, B., Vizcarguenaga, M. I., Zanaro, N. L., Suva, M. V., Kordich, L., Florentini, L., Diaz, M., Vitacco, M., Sanchez Avalos, J. C. (1999) Hemolytic uremic syndrome in children: platelet aggregation and membrane glycoproteins. J. Pediatr. Hematol. Oncol. 21, 123-128.
52. Olikowsky, T., Wang, Z. Q., Dudhane, A., Horowitz, H., Conti, B., Hoffmann, M. K. (1997) Two distinct pathways of human macrophage differentiation are mediated by interferon-γ and interleukin-10. Immunology 91, 104-108.
53. Calzada-Wack, J. C., Frankenberger, M., Ziegler-Heitbrock, H. W. (1996) Interleukin-10 drives human monocytes to CD16 positive macrophages. J. Inflamm. 46, 78-85.
54. Yamamoto, T., Nagayama, K., Satomura, K., Honda, T., Okada, S. (2000) Increased serum IL-10 and endothelin levels in hemolytic uremic syndrome caused by Escherichia coli 0157. Nephron 84, 326-332.
55. Proulx, F., Litauen, C., Turgeon, J. P., Mariscalco, M. M., Seidman, E. (2000) Circulating levels of transforming growth factor-β1 and lymphokines among children with hemolytic uremic syndrome. Am. J. Kidney Dis. 35, 29-34.
56. Scherberich, J. E. (2003) Proinflammatory blood monocytes: main effector and target cells in systemic and renal disease; background and therapeutic implications. Int. J. Clin. Pharmacol. Ther. 41, 459-464.
57. Herra, C. M., Keane, C. T., Whelan, A. (1996) Increased expression of Fc γ receptors on neutrophils and monocytes may reflect ongoing bacterial infection. J. Med. Microbiol. 44, 135-140.
58. Fingerle-Rowson, G., Angstwurm, M., Andreesen, R., Ziegler-Heitbrock, H. W. (1998) Selective depletion of CD14+ CD16+ monocytes by glucocorticoid therapy. Clin. Exp. Immunol. 112, 501-506.
59. Kummerle-Deschner, J. B., Hoffmann, M. K., Niethammer, D., Dannecker, G. E. (1998) Pediatric rheumatology: autoimmune mechanisms and therapeutic strategies. Immunol. Today 19, 250-253.