Doubly branched hexasaccharide epitope on the cell wall polysaccharide of group A streptococci recognized by human and rabbit antisera

Infection and Immunity

Volumn 73, Issue 10, 2005, Pages 6383-6389

  Michon, Francis ^a   Moore, Samuel L ^a   Kim, John ^a   Blake, Milan S ^b   Auzanneau, France Isabelle ^c   Johnston, Blair D ^c   Johnson, Margaret A ^c   Pinto, B Mario ^c  

^a Baxter Vaccines   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; EPITOPE; HAPTEN; HEXASACCHARIDE; OLIGOSACCHARIDE; PENTASACCHARIDE; POLYCLONAL ANTISERUM; POLYSACCHARIDE; TRISACCHARIDE; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL CELL WALL; CHEMICAL STRUCTURE; CONJUGATE; HUMAN; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; RABBIT; SEROLOGY; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS GROUP A; STREPTOCOCCUS INFECTION;

ANIMALS; ANTIBODIES, BACTERIAL; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; CELL WALL; GLYCOCONJUGATES; HAPTENS; HUMANS; IMMUNE SERA; IMMUNODOMINANT EPITOPES; MOLECULAR SEQUENCE DATA; POLYSACCHARIDES, BACTERIAL; RABBITS;

EID: 25444528708     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.10.6383-6389.2005     Document Type: Article

References (40)

1. Anonymous. 1980. World Health Organization: community control of rheumatic heart disease in developing countries. 1. A major public health problem. W. H. O. Chron. 34:336-345.
2. Auzanneau, F.-I., and B. M. Pinto. 1996. Preparation of antigens and immunoadsorbents corresponding to the Streptococcus group A cell-wall polysaccharide. Bioorg. Med. Chem. 4:2003-2010.
3. Auzanneau, F.-I., F. Forooghian, and B. M. Pinto. 1996. Efficient, convergent syntheses of oligosaccharide allyl glycosides corresponding to the Streptococcus group A cell-wall polysaccharide. Carbohydr. Res. 291:21-41.
4. Benaissa-Trouw, B., D. J. Lefeber, J. P. Kamerling, J. F. G. Vliegenthart, K. Kraaijeveld, and H. Snippe. 2001. Synthetic polysaccharide type 3-related di-, tri-, and tetrasaccharide-CRM197 conjugates induce protection against Streptococcus pneumoniae type 3 in mice. Infect. Immun. 69:4698-4701.
5. Bisno, A. L. 1985. Nonsuppurative poststreptococcal sequelae: rheumatic fever and glomerulonephritis, p. 1133-1142. In G. L. Mandrell, R. G. Douglas, and J. E. Bennett (ed.), Principles and practice of infectious diseases, 2nd ed. Wiley, New York, N.Y.
6. Blake, M. S., J. B. Zabriskie, J. Y. Tai, and F. Michon. February 2, 1999. U.S. patent 5.866,135.
7. D'Ambra, A., J. E. Baugher, P. E. Concannon, R. A. Pon, and F. Michon. 1997. Direct and indirect methods for molar-mass analysis of fragments of the capsular polysaccharide of Haemophilus influenzae type b. Anal. Biochem. 250:228-236.
8. Harris, S. L., L. Craig, J. S. Mehroke, M. Rashed, M. B. Zwick, K. Kenar, E. J. Toone, N. Greenspan, F.-I. Auzanneau, J. R. Marino Albernas, B. M. Pinto, and J. K. Scott. 1997. Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies. Proc. Natl. Acad. Sci. USA 94:2454-2459.
9. Hoog, C., A. Rotondo, B. D. Johnston, and B. M. Pinto. 2002. Synthesis and conformational analysis of a pentasaccharide corresponding to the cell-wall polysaccharide of the group A Streptococcus. Carbohydr. Res. 337:2023-2036.
10. Jennings, H. J., and C. Lugowski. 1981. Immunochemistry of group-A, group-B, and group-C meningococcal polysaccharide tetanus toxoid conjugates. J. Immunol. 127:1011-1018.
11. Johnson, M. A., and B. M. Pinto. 2002. Saturation transfer difference 1D-TOCSY experiments to map the topography of oligosaccharides recognized by a monoclonal antibody directed against the cell-wall polysaccharide of group A Streptococcus. J. Am. Chem. Soc. 124:15368-15374.
12. Johnson, M. A., and B. M. Pinto. 2004. NMR spectroscopic and molecular modeling studies of protein-carbohydrate and protein-peptide interactions. Carbohydr. Res. 339:907-928.
13. Kamath, V. P., P. Diedrich, and O. Hindsgaul. 1996. Use of diethyl squarate for the coupling of oligosaccharide amines to carrier proteins and characterization of the resulting neoglycoproteins by MALDI-TOF mass spectrometry. Glycoconj. J. 13:315-319.
14. Kehoe, M. A. 1991. Group A streptococcal antigens and vaccine potential. Vaccine 9:797-806.
15. Kreis, U. C., V. Varma, and B. M. Pinto. 1995. Application of 2-dimensional NMR-spectroscopy and molecular-dynamics simulations to the conformational-analysis of oligosaccharides corresponding to the cell-wall polysaccharide of Streptococcus group-A. Int. J. Biol. Macromol. 17:117-130.
16. Lancefield, R. C. 1932. A serological differentiation of human and other groups of hemolytic streptococci. J. Exp. Med. 57:571-595.
17. Markowitz, M. 1981. Observations on the epidemiology and preventability of rheumatic-fever in developing countries. Clin. Ther. 4:240-251.
18. McCarty, M. 1952. The lysis of group A hemolytic streptococci by extracellular enzymes of Streptomyces albus. II. Nature of the cellular substrate attacked by the lytic enzymes. JEM 96:569-581.
19. McCarty, M. 1956. Variation in the group-specific carbohydrate of group A streptococci. II. Studies on the chemical basis for serological specificity of the carbohydrates. JEM 104:629-643.
20. McCarty, M., and R. C. Lancefield. 1955. Variation in the group-specific carbohydrate of group A streptococci. I. Immunochemical studies on the carbohydrates of variant strains. JEM 102:11-28.
21. Miceika, B. G., A. S. Vitous, and K. D. Thompson. 1985. Detection of group A streptococcal antigen directly from throat swabs with a ten-minute latex agglutination test. J. Clin. Microbiol. 21:467-469.
22. Michon, F., R. Chalifour, R. Feldman, M. Wessels, D. L. Kasper, A. Gamian, V. Pozsgay, and H. J. Jennings. 1991. The alpha-L-(1-2)- trirhamnopyranoside epitope on the group-specific polysaccharide of group B streptococci. Infect. Immun. 59:1690-1696.
23. Nowak, R. 1994. Bacteriology-flesh-eating bacteria-not new, but still worrisome. Science 264:1665.
24. Pitner, J. B., W. F. Beyer, T. M. Venetta, C. Nycz, M. J. Mitchell, S. L. Harris, J. R. Marino-Albernas, F.-I. Auzanneau, F. Forooghian, and B. M. Pinto. 2000. Bivalency and epitope specificity of a high-affinity IgG3 monoclonal antibody to the Streptococcus group A carbohydrate antigen. Molecular modeling of a Fv fragment. Carbohydr. Res. 324:17-29.
25. Pozsgay, V. 2001. Oligosaccharide-protein conjugates as vaccine candidates against bacteria. Adv. Carbohydr. Chem. Biochem. 56:153-199.
26. Read, S. E., and J. B. Zabriskie (ed.) 1980. Streptococcal diseases and the immune response. Proceedings of a Symposium Held in Trinidad, November 7-11, 1977. Academic Press, New York, N.Y.
27. Reimer, K. B., M. A. J. Gidney, D. R. Bundle, and B. M. Pinto. 1992. Immunochemical characterization of polyclonal and monoclonal Streptococcus group-A antibodies by chemically denned glycoconjugates and synthetic oligosaccharides. Carbohydr. Res. 232:131-142.
28. Riesen, W. F., F. Skvaril, and D. G. Braun. 1976. Natural infection of man with group A streptococci. Levels; restriction in class, subclass, and type; and clonal appearance of polysaccharide-group-specific antibodies. Scand. J. Immunol. 5:383-390.
29. Salvadori, L. G., M. S. Blake, M. McCarty, J. Y. Tai, and J. B. Zabriskie. 1995. Group-A Streptococcus-liposome ELISA antibody-titers to group-A polysaccharide and opsonophagocytic capabilities of the antibodies. J. Infect. Dis. 171:593-600.
30. Stevens, D. L. 1997. The toxins of group A Streptococcus, the flesh eating bacteria. Immunol. Investig. 26:129-150.
31. Stuike-Prill, R., and B. M. Pinto. 1995. Conformational analysis of oligosaccharides corresponding to the cell-wall polysaccharide of the Streptococcus group A by Metropolis Monte Carlo simulations. Carbohydr. Res. 279:59-73.
32. Swedo, S. E., H. Leonard, M. Garvey, B. Mittleman, A. Allen, S. Perlmutter, L. Lougee, S. Dow, J. Zamkoff, and B. Dubbert. 1998. Pediatric autoimmune neuropsychiatric disorders associated streptococcal infections: clinical description of the first 50 cases. Am. J. Psychiatry 155:264-271.
33. Tietze, L. F., C. Schroter, S. Gabius, U. Brinck, A. Goerlachgraw, and H. J. Gabius. 1991. Conjugation of para-aminophenyl glycosides with squaric acid diester to a carrier protein and the use of neoglycoprotein in the histochemical detection of lectins. Bioconjug. Chem. 2:148-153.
34. Venezia, R. A., A. Ryan, S. Alward, and W. A. Kostun. 1985. Evaluation of a rapid method for the detection of streptococcal group A antigen directly from throat swabs. J. Clin. Microbiol., 21:395-398.
35. Wannamaker, L. W. 1979. Changes and changing concepts in the biology of group A-streptococci and in the epidemiology of streptococcal infections. Rev. Infect. Dis. 1:967-975.
36. Weimar, T., S. L. Harris, J. B. Pitner, K. Bock, and B. M. Pinto. 1995. Transferred nuclear Overhauser enhancement experiments show that the monoclonal-antibody Strep-9 selects a local minimum conformation of a Streptococcus group-A trisaccharide-hapten. Biochemistry 34:13672-13681.
37. Weiss, K. A., and M. Laverdiere. 1997. Group A Streptococcus invasive infections: a review. Can. J. Surg. 40:18-25.
38. Wright, K. 1990. Bad news bacteria. Science 249:22-24.
39. Zabriskie, J. B. 1985. Rheumatic-fever-the interplay between host, genetics, and microbe. Circulation 71:1077-1086.
40. Zabriskie, J. B., T. PoonKing, M. S. Blake, F. Michon, and M. Yoshinaga. 1997. Phagocytic, serological, and protective properties of streptococcal group A carbohydrate antibodies. Adv. Exp. Med. Biol. 418:917-919.