Reduced iC3b-mediated phagocytotic capacity of pulmonary neutrophils in cystic fibrosis

Clinical and Experimental Immunology

Volumn 142, Issue 1, 2005, Pages 68-75

  Morris, M R ^a,b   Doull, I J M ^b   Dewitt, S ^a   Hallett, M B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

Ca2+ signalling; Cystic fibrosis; Neutrophils; Phagocytosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT RECEPTOR; PROTEIN CR3; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; ZYMOSAN;

ADOLESCENT; ARTICLE; BLOOD ANALYSIS; CELL SURFACE; CHILD; CIRCULATION; CONTROLLED STUDY; CYSTIC FIBROSIS; DEFENSE MECHANISM; FEMALE; HISTOCHEMISTRY; HUMAN; IMMUNITY; INFANT; LUNG BLOOD FLOW; LUNG LAVAGE; MALE; MUTATION; NEUTROPHIL; NEWBORN; PHAGOCYTOSIS; PRIORITY JOURNAL; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ADOLESCENT; ANTIGENS, CD18; BRONCHOALVEOLAR LAVAGE FLUID; CALCIUM; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; COMPLEMENT C3B; CYSTIC FIBROSIS; CYTOSOL; FEMALE; HUMANS; INFANT; LUNG; MACROPHAGE-1 ANTIGEN; MALE; NEUTROPHILS; PHAGOCYTOSIS; SIGNAL TRANSDUCTION; ZYMOSAN;

EID: 25444492827     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02893.x     Document Type: Article

References (22)

1. Armstrong DS, Grimwood K, Carlin JB et al. Lower airway inflammation in infants and young children with cystic fibrosis. Am J Respir Crit Care Med 1997; 156:1197-204.
2. Hallett MB, Lloyds D. Neutrophil priming; the cellular signals which say 'amber' but not 'green'. Immunol Today 1995; 16:264-8.
3. 2+- complexed crystal structures. J Cell Biol 1998; 143:1523-34.
4. 2+ changes and calpain activation are required for β2 integrin-accelerated phagocytosis by human neutrophils. J Cell Biol 2002; 159:181-9.
5. Khan TZ, Wagener JS, Bost T et al. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995; 151:1075-82.
6. Zahm JM, Gaillard D, Dupuit F et al. Early alterations in airway mucociliary clearance and inflammation of the lamina propria in CF mice. Am J Physiol 1997; 272:C853-9.
7. Nakamura H, Yoshimura K, McElvaney NG et al. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest 1992; 89:1478-84.
8. Venaille TJ, Ryan G, Robinson BW. Epithelial cell damage is induced by neutrophil-derived, not pseudomonas-derived, proteases in cystic fibrosis sputum. Respir Med 1998; 92:233-40.
9. Tosi MF, Zakem H, Berger M. Neutrophil elastase cleaves C3bi on opsonised pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. J Clin Invest 1990; 86:300-8.
10. Kemp T, Schram-Doumont A, van Geffel R et al. Alteration of the N-formyl-methionyl-leucyl-phenylalanine-induced response in cystic fibrosis neutrophils. Pediatr Res 1986; 20:520-6.
11. Witko-Sarsat V, Allen RC, Paulais M et al. Disturbed myeloperoxidase- dependent activity of neutrophils in cystic fibrosis homozygotes and heterozygotes, and its correction by amiloride. J Immunol 1996; 157:2728-35.
12. Russell KJ, McRedmond J, Mukherji N et al. Neutrophil adhesion molecule surface expression and responsiveness in cystic fibrosis. Am J Respir Crit Care Med 1998; 157:756-61.
13. 2+ in neutrophils. Methods: Companion Meth Enzymol 1996; 9:591-606.
14. 2+ controls time not space. J Cell Sci 2003; 116:2857-65.
15. Wettermark G, Stymme H, Brolin SE et al. Substrate analysis in single cells. 1. Determination of ATP. Anal Biochem 1975; 63:293-307.
16. Borregaard N, Herlin T. Energy metabolism of human neutrophils during phagocytosis. J Clin Invest 1982; 70:550-7.
17. Cabrini G, De Togni P. Increased cytosolic calcium in cystic fibrosis neutrophils effect on stimulus secretion coupling. Life Sci 1985; 36:1561-7.
18. Suter S, Lew PD, Ballaman J et al. Intracellular calcium handling in cystic fibrosis: normal cytosolic calcium and intracellular calcium stores in neutrophils. Pediatr Res 1985; 19:346-8.
19. Knowles MR, Robinson JM, Wood RE. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. J Clin Invest 1997; 100:2588-95.
20. 2+ changes in human neutrophils. Biochim Biophys Acta 2001; 1538:20-7.
21. Crawford I, Maloney PC, Zeitlin PL et al. Immunocytochemical localization of the cystic fibrosis gene product CFTR. Proc Natl Acad Sci USA 1991; 88:9262-6.
22. Yoshimura K, Nakamura H, Trapnell BC et al. Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin. Nucl Acids Res 1991; 19:5417-23.