A novel aerobactin utilization cluster in Vibrio vulnificus with a gene involved in the transcription regulation of the iutA homologue

Microbiology and Immunology

Volumn 49, Issue 9, 2005, Pages 823-834

  Tanabe, Tomotaka ^a   Naka, Ayaka ^a   Aso, Hiroaki ^a,e   Nakao, Hiroshi ^a   Narimatsu, Shizuo ^a   Inoue, Yuji ^b   Ono, Tomomichi ^c   Yamamoto, Shigeo ^a,d  

^a OKAYAMA UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

^e SHUJITSU UNIVERSITY   (Japan)

Author keywords

ABC transport system; Aerobactin utilization gene cluster; Iron regulated gene; Transcription regulation

Indexed keywords

ABC TRANSPORTER; AEROBACTIN; BACTERIAL PROTEIN; IRON; OUTER MEMBRANE PROTEIN; RECEPTOR PROTEIN; SIDEROPHORE;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIUM CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; GENE CLUSTER; GENE LIBRARY; GENE SYNTHESIS; GENETIC COMPLEMENTATION; GENETIC TRANSCRIPTION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PROTEIN EXPRESSION; REGULATOR GENE; SEQUENCE HOMOLOGY; TITRIMETRY; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; VIBRIO VULNIFICUS;

BACTERIA (MICROORGANISMS); VIBRIO VULNIFICUS;

EID: 25444488281     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2005.tb03671.x     Document Type: Article

References (56)

1. Albrecht-Gary, A., and Crumbliss, A.L. 1998. Coordination chemistry of siderophores: thermodynamics and kinetics of iron chelation and release. Met. Ions Biol. Syst. 35: 239-327.
2. Altschul, S.F., Madden, T.I., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D.J. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402.
3. Andrews, S.C., Robinson, A.K., and Rodríguez-Quiñones, F. 2003. Bacterial iron homeostasis. FEMS Microbiol. Rev. 27: 215-237.
4. Aso, H., Miyoshi, S., Nakao, H., Okamoto, K., and Yamamoto, S. 2002. Induction of an outer membrane protein of 78 kDa in Vibrio vulnificus cultured in the presence of desferrioxamine B under iron-limiting conditions. FEMS Microbiol. Lett. 212: 65-70.
5. Braun, V., and Hantke, K. 1991. Genetics of bacterial iron transport, p. 107-138. In Winkelmann, G. (ed), Handbook of microbial iron chelates, CRC Press, Boca Raton.
6. Braun, V., Hantke, K., and Köster, W. 1998. Bacterial iron transport: mechanisms, genetics, and regulation. Met. Ions Biol. Syst. 35: 67-145.
7. Burkhardt, R., and Braun, V. 1987. Nucleotide sequence of the fhuC and fhuD genes involved in iron (III) hydroxamate transport: domains in FhuC homologous to ATP-binding proteins. Mol. Gen. Genet. 209: 49-55.
8. Chart, H., and Griffiths, E. 1985. Antigenic and molecular homology of the ferric enterobactin receptor of Escherichia coli. J. Gen. Microbiol. 131: 1503-1509.
9. Chen, C.Y., Wu, K.M., Chang, Y.C., and 12 other authors. 2003. Comparative genome analysis of Vibrio vulnificus, a marine pathogen. Genome Res. 13: 2577-2587.
10. Coulton, J.W., Mason, P., and Allatt, D.D. 1987. fhuC and fhuD genes for iron (III)-ferrichrome transport into Escherichia coli K-12. J. Bacteriol. 169: 3844-3849.
11. Crosa, J.H. 1997. Signal transduction and transcriptional and posttranscriptional control of iron-regulated genes in bacteria. Microbiol. Mol. Biol. Rev. 61: 319-336.
12. de Lorenzo, V., and Martinez, J.L. 1988. Aerobactin production as a virulence factor: a reevaluation. Eur. J. Clin. Microbiol. Infect. Dis. 7: 621-629.
13. Drechsel, H., and Winkelmann, G. 1997. Iron chelation and siderophores, p. 1-49. In Winkelman, G., and Carrano, C.J. (eds), Transition metals in microbial metabolism, Harwood Academic, Amsterdam.
14. Escolar, L., Pérez-Martin, J., and de Lorenzo, V. 1999. Opening the iron box: transcriptional metalloregulation by the Fur protein. J. Bacteriol. 181: 6223-6229.
15. Fujita, Y., Fujita, T., Miwas, Y., Nihashi, J., and Aratani, Y. 1986. Organization and transcription of the gluconate operon, gnt, of Bacillus subtilis. J. Biol. Chem. 261: 13744-13753.
16. Funahashi, T., Moriya, K., Uemura, S., Miyoshi, S., Shinoda, S., Narimatsu, S., and Yamamoto, S. 2002. Identification and characterization of pvuA, a gene encoding the ferric vibrioferrin receptor protein in Vibrio parahaemolyticus. J. Bacteriol. 184: 936-946.
17. Funahashi, T., Tanabe, T., Aso, H., Nakao, H., Fujii, Y., Okamoto, K., Narimatsu, S., and Yamamoto, S. 2003. An iron-regulated gene required for utilization of aerobactin as an exogenous siderophore in Vibrio parahaemolyticus. Microbiology 149: 1217-1225.
18. Gallant, C.V., Ponnampalam, T., Spencer, H., Hinton, J.C.D., and Martin, N.L. 2004. H-NS represses Salmonella enterica serovar Typhimurium dsbA expression during exponential growth. J. Bacteriol. 186: 910-918.
19. Griffiths, E., Sigel, S.P., Payne, S.M., and Neilands, J.B. 1984. Vibriobactin, a siderophore from Vibrio cholerae. J. Biol. Chem. 259: 383-385.
20. Griffiths, E., and Williams, P. 1999. The iron-uptake systems of pathogenic bacteria, fungi and protozoa, p. 87-212. In Bullen, J.J., and Griffiths, E. (eds), Iron and infection, 2nd ed, John Wiley & Sons, New York.
21. Haydon, D., and Guest, J.R. 1991. A new family of bacterial regulatory proteins. FEMS Microbiol. Lett. 63: 291-295.
22. Haygood, M.G., Holt, P.D., and Butler, A. 1993. Aerobactin production by a planktonic marine Vibrio sp. Limnol. Oceanogr., 38: 1091-1097.
23. Jones, D.T. 1999. Protein secondary structure prediction based on position-specific scoring matrices. J. Mol. Biol. 292: 195-202.
24. Keen, N.T., Tamaki, S., Kobayashi, D., and Trollinger, D. 1988. Improved broad-host-range plasmids for DNA cloning in gram-negative bacteria. Gene 70: 191-197.
25. Köster, W., and Braun, V. 1986. Iron hydroxamate transport of Escherichia coli: nucleotide sequence of the fhuB gene and identification of the protein. Mol. Gen. Genet. 204: 435-442.
26. Krone, W.J.A., Stegehuis, F., Koningstein, G., van Doorn, C., Roosendaal, B., de Graaf, F.K., and Oudega, B. 1985. Characterization of the pColV-K30 encoded cloacin DF13/aerobactin outer membrane receptor protein of Escherichia coli: isolation and purification of the protein and analysis of its nucleotide sequence and primary structure. FEMS Microbiol. Lett. 26: 153-161.
27. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
28. Linkou, D.A., and Oliver, D.J. 1999. Pathogenesis of Vibrio vulnificus. FEMS Microbiol. Lett. 174: 207-214.
29. Litwin, C.M., and Byrne, B.L. 1998. Cloning and characterization of an outer membrane protein of Vibrio vulnificus required for heme utilization: regulation of expression and determination of the gene sequence. Infect. Immun. 66: 3134-3141.
30. Litwin, C.M., and Quackenbush, J. 2001. Characterization of a Vibrio vulnificus LysR homologue, HutR, which regulates expression of the haem uptake outer membrane protein, HupA. Microb. Pathog. 31: 295-307.
31. Liu, P., and Shokrani, F. 1978. Biological activities of pyochelins: iron-chelating agents of Pseudomonas aeruginosa. Infect. Immun. 22: 87-890.
32. Miller, V.L., and Mekalanos, J.J. 1988. A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J. Bacteriol. 170: 2575-2583.
33. Moon, Y.-H., Tanabe, T., Funahashi, T., Shiuchi, K., Nakao, H., and Yamamoto, S. 2004. Identification and characterization of two contiguous operons required for aerobactin transport and biosynthesis in Vibrio mimicus. Microbiol. Immunol. 48: 389-398.
34. Murakami, K., Ohta, S., Fuse, H., Takimura, O., Kamimura, K., and Yamaoka, Y. 1995. Vibrio species isolated from coastal ocean produces aerobactin. Microbios 84: 231-238.
35. Nishibuchi, M., Kumagai, K., and Kaper, J.B. 1991. Contribution of the tdh1 gene of Kanagawa phenomenon-positive Vibrio parahaemolyticus to production of extracellular thermostable direct hemolysin. Microb. Pathog. 11: 453-460.
36. Okujo, N., Saito, M., Yamamoto, S., Yoshida, T., Miyoshi, S., and Shinoda, S. 1994. Structure of vulnibactin, a new polyamine-containing siderophore from Vibrio vulnificus. BioMetals 7: 109-116.
37. Okujo, N., and Yamamoto, S. 1994. Identification of the siderophore from Vibrio hollisae and Vibrio mimicus as aerobactin. FEMS Microbiol. Lett. 118: 187-192.
38. Pearson, W.R., and Lipman, D.J. 1988. Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. U.S.A. 85: 2444-2448.
39. Potasman, I., Paz, A., and Odeh, M. 2002. Infectious outbreak associated with bivalve shellfish consumption: a worldwide perspective. Clin. Infect. Dis. 35: 921-928.
40. Pradel, E., and Locht, C. 2001. Expression of the putative siderophore receptor gene bfrZ is controlled by the extracytoplasmic-function sigma factor BupI in Bordetella bronchiseptica. J. Bacteriol. 183: 2910-2917.
41. Reizer, A., Deutscher, J., Saier, M.H., Jr., and Reizer, J. 1991. Analysis of the gluconate (gnt) operon of Bacillus subtilis. Mol. Microbiol. 5: 1081-1089.
42. Rigali, S., Derouaux, A., Giannotta, F., and Dusart, J. 2002. Subdivision of the helix-turn-helix GntR family of bacterial regulators in the FadR, HutC, MocR, and YtrA subfamilies. J. Biol. Chem. 277: 12507-12515.
43. Russell, L.M., and Holmes, R.K. 1985. Highly toxinogenic but avirulent Park-Williams 8 strain of Corynebacterium diphtheriae does not produce siderophore. Infect. Immun. 47: 575-578.
44. Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989. Molecular cloning: a laboratory manual, 2nd ed, Cold Spring Harbor Laboratory, Cold Spring Harbor.
45. Schmitt, M.P. 1999. Identification of a two-component signal transduction system from Corynebacterium diphtheriae that activates gene expression in response to the presence of heme and hemoglobin. J. Bacteriol. 181: 5330-5340.
46. Sebulsky, M.T., Hohnstein, D., Hunter, M.D., and Heinrichs, D.E. 2000. Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureus. J. Bacteriol. 182: 4394-4400.
47. Stojiljkovic, I., Bäumler, A.J., and Hantke, K. 1994. Fur regulon in gram-negative bacteria. Identification and characterization of new iron-regulated Escherichia coli genes by a Fur titration assay. J. Mol. Biol. 236: 531-545.
48. Towbin, H., Staehelin, T., and Gordon, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 76: 4350-4354.
49. van Aalten, D.M.F., DiRusso, C.C., Knudsen, J., and Wierenga, R.K. 2000. Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold. EMBO J. 19: 5167-5177.
50. van Aalten, D.M.F., DiRusso, C.C., and Knudsen, J. 2000. The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadR. EMBO J. 20: 2041-2050.
51. Vanderpool, C.K., and Armstrong, S.K. 2003. Heme-responsive transcriptional activation of Bordetella bhu genes. J. Bacteriol. 185: 909-917.
52. Visca, P., Leoni, L., Wilson, M.J., and Lamont, I.L. 2002. Iron transport and regulation, cell signaling and genomics: lessons from Escherichia coli and Pseudomonas. Mol. Microbiol. 45: 1177-1190.
53. Wandersman, C., and Delepelaire, P. 2004. Bacterial iron sources: from siderophores to hemophores. Annu. Rev. Microbiol. 58: 611-647.
54. Webster, A.C.D., and Litwin, C.M. 2000. Cloning and characterization of vuuA, a gene encoding the Vibrio vulnificus ferric vulnibactin receptor. Infect. Immun. 68: 526-534.
55. Winkelmann, G. 2004. Ecology of siderophores, p. 437-450. In Crosa, J.H., Mey, A.R., and Payne, S.M. (eds), Iron transport in bacteria, American Society for Microbiology, Washington, DC.
56. Wright, A.C., Simpson, L.M., and Oliver, J.D. 1981. Role of iron in the pathogenesis of Vibrio vulnificus infections. Infect. Immun. 34: 503-507.