Protamine as an efficient membrane-translocating peptide

Bioconjugate Chemistry

Volumn 16, Issue 5, 2005, Pages 1240-1245

  Reynolds, Fred ^a   Weissleder, Ralph ^a   Josephson, Lee ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; FLUORESCENCE; LANTHANUM COMPOUNDS; NANOPARTICLES;

CELL-BE; CELL/B.E; CELL/BE; FLUOROCHROMES; LIVE CELL; N-HYDROXYSUCCINIMIDE; NUCLEAR LOCALIZATION; PHARMACEUTICAL APPLICATIONS; POSITIVELY CHARGED PROTEINS; TAT PEPTIDE;

PEPTIDES;

CARRIER PROTEIN; ESTER DERIVATIVE; FLUORESCENT DYE; FLUOROCHROME; MEMBRANE PROTEIN; NANOPARTICLE; PEPTIDE DERIVATIVE; PROTAMINE; RHODAMINE; SUCCINIMIDE DERIVATIVE; TETRAMETHYLRHODAMINE; TETRAMETHYLSUCCINIMIDE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COVALENT BOND; HELA CELL; HUMAN; HUMAN CELL; INTERNALIZATION; NUCLEAR LOCALIZATION SIGNAL; SALMON; STAINING; TIME;

EID: 25444484384     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0501451     Document Type: Article

References (31)

1. Brange, J., and Langkjaer, L. (1992) Chemical stability of insulin. 3. Influence of excipients, formulation, and pH. Acta Pharm. Nord. 4, 149-58.
2. Brange, J., and Langkjaer, L. (1997) Insulin formulation and delivery. Pharm. Biotechnol. 10, 343-409.
3. Carr, J. A., and Silverman, N. (1999) The heparin-protamine interaction. A review. J. Cardiovasc. Surg. (Torino) 40, 659-66.
4. Fuentes-Mascorro, G., Serrano, H., and Rosado, A. (2000) Sperm chromatin. Arch. Androl. 45, 215-25.
5. Meistrich, M. L., Mohapatra, B., Shirley, C. R., and Zhao, M. (2003) Roles of transition nuclear proteins in spermiogenesis. Chromosoma 111, 483-8.
6. Futaki, S., Suzuki, T., Ohashi, W., Yagami, T., Tanaka, S., Ueda, K., and Sugiura, Y. (2001) Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J. Biol. Chem. 276, 5836-40.
7. Rothbard, J. B., Garlington, S., Lin, Q., Kirschberg, T., Kreider, E., McGrane, P. L., Wender, P. A., and Khavari, P. A. (2000) Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation. Nat. Med. 6, 1253-7.
8. Polyakov, V., Sharma, V., Dahlheimer, J. L., Pica, C. M., Luker, G. D., and Piwnica-Worms, D. (2000) Novel Tat-peptide chelates for direct transduction of technetium-99m and rhenium into human cells for imaging and radiotherapy. Bioconjugate Chem. 11, 762-71.
9. Eguchi, A., Akuta, T., Okuyama, H., Senda, T., Yokoi, H., Inokuchi, H., Fujita, S., Hayakawa, T., Takeda, K., Hasegawa, M., and Nakanishi, M. (2001) Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells. J. Biol. Chem. 276, 26204-10.
10. Ford, K. G., Souberbielle, B. E., Darling, D., and Farzaneh, F. (2001) Protein transduction: an alternative to genetic intervention? Gene Ther. 8, 1-4.
11. Snyder, E. L., and Dowdy, S. F. (2001) Protein/peptide transduction domains: potential to deliver large DNA molecules into cells. Curr. Opin. Mol. Ther. 3, 147-52.
12. Wunderbaldinger, P., Josephson, L., and Weissleder, R. (2002) Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjugate Chem. 13, 264-8.
13. Zhao, M., Kircher, M. F., Josephson, L., and Weissleder, R. (2002) Differential conjugation of tat Peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjugate Chem. 13, 840-4.
14. Josephson, L., Perez, J. M., and Weissleder, R. (2001) Magnetic nanosensors for the detection of oligonucleotide sequences. Agnew Chem. Int. Ed. 40, 3204-3206.
15. Koch, A. M., Reynolds, F., Kircher, M. F., Merkle, H. P., Weissleder, R., and Josephson, L. (2003) Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells. Bioconjugate Chem. 14, 1115-21.
16. Reynolds, F., O'Loughlin, T., Weissleder, R., and Josephson, L. (2005) Method of determining nanoparticle core weight. Anal. Chem. 77, 814-7.
17. Koch, A. M., Reynolds, F., Merkle, H. P., Weissleder, R., and Josephson, L. (2005) Transport Of Surface-Modified Nanoparticles Through Cell Monolayers. Chembiochem 6, 337-345.
18. Vives, E., Brodin, P., and Lebleu, B. (1997) A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J. Biol. Chem. 272, 16010-7.
19. Hermanson, G. T. (1996) Bioconjugate Techniques, Academic Press, San Diego CA.
20. Suzuki, T., Futaki, S., Niwa, M., Tanaka, S., Ueda, K., and Sugiura, Y. (2002) Possible existence of common internalization mechanisms among arginine-rich peptides. J. Biol. Chem. 277, 2437-43.
21. Mann, D. A., and Frankel, A. D. (1991) Endocytosis and targeting of exogenous HIV-1 Tat protein. EMBO J 10, 1733-9.
22. Josephson, L., Tung, C. H., Moore, A., and Weissleder, R. (1999) High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjugate Chem. 10, 186-91.
23. Fawell, S., Seery, J., Daikh, Y., Moore, C., Chen, L. L., Pepinsky, B., and Barsoum, J. (1994) Tat-mediated delivery of heterologous proteins into cells. Proc. Natl. Acad. Sci. U. S. A. 91, 664-8.
24. Schwarze, S. R., and Dowdy, S. F. (2000) In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol. Sci. 21, 45-8.
25. Torchilin, V. P., Rammohan, R., Weissig, V., and Levchenko, T. S. (2001) TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc. Natl. Acad. Sci. U. S. A. 98, 8786-91.
26. Richard, J. P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M. J., Chernomordik, L. V., and Lebleu, B. (2003) Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J. Biol. Chem. 278, 585-90.
27. Lundberg, M., Wikstrom, S., and Johansson, M. (2003) Cell surface adherence and endocytosis of protein transduction domains. Mol. Ther. 8, 143-50.
28. Lindgren, M., Hallbrink, M., Prochiantz, A., and Langel, U. (2000) Cell-penetrating peptides. Trends Pharmacol. Sci. 21, 99-103.
29. Vives, E., Richard, J. P., Rispal, C., and Lebleu, B. (2003) TAT peptide internalization: seeking the mechanism of entry. Curr. Protein Pept. Sci. 4, 125-32.
30. Futaki, S. (2005) Membrane-permeable arginine-rich peptides and the translocation mechanisms. Adv. Drug Delivery Rev. 57, 547-58.
31. Wadia, J. S., and Dowdy, S. F. (2005) Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer. Adv. Drug Delivery Rev. 57, 579-96.