Hyponatraemia in the elderly

CME Journal Geriatric Medicine

Volumn 7, Issue 2, 2005, Pages 76-85

  Fegan, Gerry ^a,b,c   Begley, Joseph ^a,d,e  

^a ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c Department of Diabetes and Endocrinology ^*  (United Kingdom)

^d POOLE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^e TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Elderly; Hyponatraemia; Osmolality; Syndrome of inappropriate antidiuretic hormone secretion (SIADH); Vasopressin

Indexed keywords

ATRIAL NATRIURETIC FACTOR; DEMECLOCYCLINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FUROSEMIDE; INDAPAMIDE; SEROTONIN UPTAKE INHIBITOR; SODIUM; SODIUM CHLORIDE; THIAZIDE DIURETIC AGENT; VASOPRESSIN; VASOPRESSIN RECEPTOR ANTAGONIST;

AGED; AGING; EXTRACELLULAR FLUID; FLUID BALANCE; FLUID INTAKE; GERIATRIC DISORDER; GLOMERULUS FILTRATION RATE; HUMAN; HYPONATREMIA; INAPPROPRIATE VASOPRESSIN SECRETION; INTRACELLULAR FLUID; KIDNEY FUNCTION; LABORATORY DIAGNOSIS; MOLECULAR MECHANICS; PATHOPHYSIOLOGY; REVIEW; SODIUM BALANCE; SODIUM BLOOD LEVEL; SODIUM METABOLISM; SODIUM RETENTION; TOTAL BODY WATER; VASOPRESSIN RELEASE; WATER METABOLISM;

EID: 25444477015     PISSN: 14751453     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (69)

1. Flear CT, Gill GV, Burn J. Hyponatraemia: mechanisms and management. Lancet 1981; 2: 26-31.
2. Lim JK and Yap KB. Hyponatraemia in hospitalised elderly patients. Med J Malaysia 2001; 56(2): 232-5.
3. Arieff AI. Hyponatremia, convulsions, respiratory arrest, and permanent brain damage after elective surgery in healthy women. N Engl J Med 1986; 314: 1529-35.
4. Baylis PH: Water and sodium homeostasis and their disorders, Weatherall DJ, Ledingham JG, Warrell DA, editors: Oxford Textbook of Medicine. Oxford, 1996, Oxford University Press; p. 3116-26.
5. Verbalis JG. Disorders of body water homeostasis. Best Pract Res Clin Endocrinol Metab 2003; 17(4): 471-503.
6. Bleich HL and Boro ES. Antidiuretic hormone. N Engl J Med 1976; 295: 659-65.
7. Ramsay D and Thrasher TN. Homeostatic mechanisms in the regulation of plasma osmolality. Acta Physiol Pol 1989; 40(3): 275-81.
8. Thompson CJ, Bland J, Burd J, et.al; The osmotic thresholds for thirst and vasopressin release are similar in healthy man. Clin Sci (Lond) 1986; 71(6): 651-6.
9. Salata RA, Verbalis JG, Robinson AG. Cold water stimulation of oropharyngeal receptors in man inhibits release of vasopressin. J Clin Endocrinol Metab 1987; 65(3): 561-7.
10. Schrier KW. Pathogenesis of sodium and water retention in high-output and low-output cardiac failure, nephrotic syndrome, cirrhosis, and pregnancy (2). N Engl J Med 1988; 319: 1127-34.
11. Bark H, Le Roith D, Nyska M, et.al; Elevations in plasma ADH levels during PEEP ventilation in the dog: mechanisms involved. Am J Physiol 1980; 239(6): E474-81.
12. Farge D, De la Coussaye JE, Beloucif S, et.al; Interactions between hemodynamic and hormonal modifications during PEEP-induced antidiuresis and antinatriuresis. Chest 1995; 107(4): 1095-100.
13. Rowe JW, Shelton RL, Helderman JH, et.al; Influence of the emetic reflex on vasopressin release in man. Kidney Int 1979; 16(6): 729-35.
14. Coslovsky R, Bruck R, Estrov Z. Hypo-osmolal syndrome due to prolonged nausea. Arch Intern Med 1984; 144(1): 191-2.
15. Agre P and Kozono D. Aquaporin water channels: molecular mechanisms for human diseases. FEBS Lett 2003; 555(1): 72-8.
16. Walters G and O'Rahilly DSJ: Disorders of fluid and electrolyte balance, Williams DL, Marks V, editors: Biochemistry in Clinical Practice. Oxford: 1994 Butterworth-Heinemann; p. 53-75.
17. Mitchell KD and Navar LG. The renin-angiotensin-aldosterone system in volume control. Baillieres Clin Endocrinol Metab 1989; 3(2): 393-430.
18. De Wardener HE. Natriuretic hormone. Clin Sci Mol Med 1977; 53(10): 1-8.
19. de Bold AJ, Borenstem HB, Veress AT, Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 1981; 28(1): 89-94.
20. Editorial. Atrial natriuretic peptide. Lancet 1986; 2: 371-2.
21. Brenner BM, Ballermann BJ, Gunning ME, Zeidel ML. Diverse biological actions of atrial natriuretic peptide. Physiol Rev 1990; 70(3): 665-99.
22. Beck LH. The aging kidney. Defending a delicate balance of fluid and electrolytes. Geriatrics 2000; 55(4): 26-8, and 31-2.
23. Lindeman RD, Adler S, Yiengst MJ, et.al; Natriuresis and carbohydrate-induced antinatriuresis after overnight fast and hydration. Nephron 1970; 7(4): 289-300.
24. Young A. Ageing and physiological functions. Philos Trans R Soc Lond B Biol Sci 1997; 352: 1837-43.
25. Miller M. Fluid and electrolyte homeostasis in the elderly: physiological changes of ageing and clinical consequences. Baillieres Clin Endocrinol Metab 1997; 11(2): 367-87.
26. Fulop T, Jr., Worum I, Csongor J, et.al; Body composition in elderly people. I. Determination of body composition by multiisotope method and the elimination kinetics of these isotopes in healthy elderly subjects. Gerontology 1985; 31(1): 6-14.
27. Ayus JC and Arieff AI. Abnormalities of water metabolism in the elderly. Semin Nephrol 1996; 16(4): 277-88.
28. George CP, Messerli FH, Genest J, et.al; Diurnal variation of plasma vasopressin in man. J Clin Endocrinol Metab 1975; 41(2): 332-8.
29. Asplund R and Aberg H. Diurnal variation in the levels of antidiuretic hormone in the elderly. J Intern Med 1991; 229(2): 131-4.
30. Phillips PA, Rolls BJ, Ledingham JG, et al; Reduced thirst after water deprivation in healthy elderly men. N Engl J Med 1984; 311: 753-9.
31. Faull CM, Holmes C, Baylis PH. Water balance in elderly people: is there a deficiency of vasopressin? Age Ageing 1993; 22(2): 114-20.
32. Crowe MJ, Forsling ML, Rolls BJ, et.al; Altered water excretion in healthy elderly men. Age Ageing 1987; 16(5): 285-93.
33. Epstein M and Hollenberg NK. Age as a determinant of renal sodium conservation in normal man. J Lab Clin Med 1976; 87(3): 411-7.
34. Anonymous. Pseudohyponatraemia. Lancet 1981; 1: 96.
35. Soupart A and Decaux G. Therapeutic recommendations for management of severe hyponatremia: current concepts on pathogenesis and prevention of neurologic complications. Clin Nephrol 1996; 46(3): 149-69.
36. Saeed BO, Beaumont D, Handley GH, Weaver JU. Severe hyponatraemia: investigation and management in a district general hospital. J Clin Pathol 2002; 55(12): 893-6.
37. Smith JC, Siddique H, Corrall RJ. Misinterpretation of serum cortisol in a patient with hyponatraemia. BMJ 2004; 328: 215-6.
38. Grinspoon SK and Biller BM. Clinical review 62: Laboratory assessment of adrenal insufficiency. J Clin Endocrinol Metab 1994; 79(4): 923-31.
39. Gillum DM and Linas SL. Water intoxication in a psychotic patient with normal renal water excretion. Am J Med 1984; 77(4): 773-4.
40. Hilden T and Svendsen TL. Hypo-osmolality in beer drinkers. Lancet
41. Schwartz WB, Bennett W, Curelop S, et.al; A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med 1957; 23(4): 529-42.
42. Bartter FC and Schwartz WB. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 1967; 42(5): 790-806.
43. Zerbe R, Stropes L, Robertson G. Vasopressin function in the syndrome of inappropriate antidiuresis. Annu Rev Med 1980; 31: 315-27.
44. Gill G and Leese G. Hyponatraemia: biochemical and clinical perspectives. Postgrad Med J 1998; 74: 516-23.
45. Wijdicks EF, Vermeulen M, ten Haaf JA, et.al; Volume depletion and natriuresis in patients with a ruptured intracranial aneurysm. Ann Neurol 1985; 18(2): 211-6.
46. Maesaka JK, Gupta S, Fishbane S. Cerebral salt-wasting syndrome: does it exist? Nephron 1999; 82(2): 100-9.
47. Cole CD, Gottfried ON, Liu JK, et.al; Hyponatremia in the neurosurgical patient: diagnosis and management. Neurosurg Focus 2004; 16(4): 9.
48. ALLHAT Investigators. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288(23): 2981-97.
49. Sunderam SG and Mankikar GD. Hyponatraemia in the elderly. Age Ageing 1983; 12(1): 77-80.
50. Sharabi Y, Illan R, Kamari Y, et.al; Diuretic induced hyponatraemia in elderly hypertensive women. J Hum Hypertens 2002; 16(9): 631-5.
51. Chow KM, Szeto CC, Wong TY, et.al; Risk factors for thiazide-induced hyponatraemia. QJM 2003; 96(12): 911-7.
52. Prichard BN, Owens CW, Woolf AS. Adverse reactions to diuretics. Eur Heart J 1992; 13 (Suppl G): 96-103.
53. Brater DC. Diuretic therapy. N Engl J Med 1998; 339: 387-95.
54. Bouman WP, Pinner G, Johnson H. Incidence of selective serotonin reuptake inhibitor (SSRI) induced hyponatraemia due to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion in the elderly. Int J Geriatr Psychiatry 1998; 13(1): 12-5.
55. Wilkinson TJ, Begg EJ, Winter AC, et.al; Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people. Br J Clin Pharmacol 1999; 47(2): 211-7.
56. Arinzon ZH, Lehman YA, Fidelman ZG, et.al; Delayed recurrent SIADH associated with SSRIs. Ann Pharmacother 2002; 36(7-8): 1175-7.
57. Elisaf MS, Konstantinides A, Siamopoulos KC. Chronic hyponatremia due to reset osmostat in a patient with colon cancer. Am J Nephrol 1996; 16(4): 349-51.
58. Adrogue HJ and Madias NE. Hyponatremia. N Engl J Med 2000; 342: 1581-9.
59. O'Rahilly S. Secretion of antidiuretic hormone in hyponatraemia: not always "inappropriate". Br Med J (Clin Res Ed) 1985; 290: 1803-4.
60. Kamoi K, Tamura T, Tanaka K, et.al; Hyponatremia and osmoregulation of thirst and vasopressin secretion in patients with adrenal insufficiency. J Clin Endocrinol Metab 1993; 77(6): 1584-8.
61. Diederich S, Franzen NF, Bahr V, et.al; Severe hyponatremia due to hypopituitarism with adrenal insufficiency: report on 28 cases. Eur J Endocrinol 2003; 148(6): 609-17.
62. Derubertis FR Jr, Michelis MF, Bloom ME, et.al; Impaired water excretion in myxedema. Am J Med 1971; 51(1): 41-53.
63. Macaron C and Famuyiwa O. Hyponatremia of hypothyroidism. Appropriate suppression of antidiuretic hormone levels. Arch Intern Med 1978; 138(5): 820-2.
64. Gross P, Reimann D, Neidel J, et al; The treatment of severe hyponatremia. Kidney Int Suppl 1998; 64: S6-11.
65. Verbalis JG. Adaptation to acute and chronic hyponatremia: implications for symptomatology, diagnosis, and therapy. Semin Nephrol 1998; 18(1): 3-19.
66. Cluitmans FH and Meinders AE. Management of severe hyponatremia: rapid or slow correction? Am J Med 1990; 88(2): 161-6.
67. Norenberg MD, Leslie KO, Robertson AS. Association between rise in serum sodium and central pontine myelinolysis. Ann Neurol 1982; 11(2): 128-35.
68. Perks WH, Walters EH, Tams IP, et.al; Demeclocycline in the treatment of the syndrome of inappropriate secretion of antidiuretic hormone. Thorax 1979: 34(3): 324-7.
69. Verbalis JG. Vasopressin V2 receptor antagonists. J Mol Endocrinol 2002; 29(1): 1-9.