βPP and tau interaction: A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease

American Journal of Pathology

Volumn 148, Issue 1, 1996, Pages 79-87

  Giaccone, Giorgio ^a   Pedrotti, Barbara ^b   Migheli, Antonio ^c   Verga, Laura ^a   Perez, Jorge ^d   Racagni, Giorgio ^d   Smith, Mark A ^e   Perry, George ^e   De Gioia, Luca ^f   Selvaggini, Carlo ^f   Salmona, Mario ^f   Ghiso, Jorge ^g   Frangione, Blas ^g   Islam, Khalid ^b   Bugiani, Orso ^a   Tagliavini, Fabrizio ^a,h  

^a Ist Naz Neurologico Carlo Besta   (Italy)

^b Gruppo Lepetit SpA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

^f MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^g NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^h DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; PROTEIN PRECURSOR; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; HUMAN; HUMAN TISSUE; NEUROFIBRILLARY TANGLE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CEREBRAL CORTEX; HUMANS; MICROSCOPY, IMMUNOELECTRON; NEUROFIBRILLARY TANGLES; PROTEIN BINDING; PROTEIN PRECURSORS; TAU PROTEINS;

EID: 9044251598     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Tomlinson BE. Ageing and the dementias. Greenfield's Neuropathology. Edited by J Hume-Adams, LW Duchenne London, Arnold, 1992, pp 1284-1410
2. Glenner GG, Wong CW: Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984, 120:885-890
3. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K Amyloid plaque protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 1985, 82.4245-4249
4. Prelli F, Castaño E, Glenner GG, Frangione B: Difference between vascular and plaque core amyloid in Alzheimer's disease J Neurochem 1988, 51 648-651
5. Kang J, Lemaire H-G, Unterbeck A, Salbaum M, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B: The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987, 325:733-736
6. Ponte P, Gonzalez-DeWhitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Lieberburg I, Fuller F, Cordell B. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 1988, 331 525-527
7. Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff LL, Gusella JF, Neve RL: Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer disease Nature 1988, 331:528-530
8. Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H: Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature 1988, 331: 530-532
9. Brion JP, Passareiro H, Nunez J, Flament-Durand J Immunological detection of tau protein in neurofibrillary tangles of Alzheimer's disease Arch Biol 1985, 95. 229-235
10. Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI: Abnormal phosphorylation of the microtubule-associated protein (tau) in Alzheimer cytoskeletal pathology Proc Natl Acad Sci USA 1986, 83.4913-4917
11. Kosik K, Orecchio LD, Binder L, Trojanowski JQ, Lee VM-Y, Lee G: Epitopes that span the tau molecule are shared with paired helical filaments Neuron 1988, 1:817-825
12. Kondo J, Honda T, Mori H, Hamada Y, Miura R, Ogawara M, Ihara Y: The carboxyl third of tau is tightly bound to paired helical filaments. Neuron 1988, 1 827-834
13. Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A: Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc Natl Acad Sci USA 1988, 85:4051-4055
14. Lee VM-Y, Balin BJ, Otvos L Jr, Trojanowski JQ A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 1991, 251:675-678
15. Bramblett GT, Goedert M, Jakes R, Merrik SE, Trojanowski JQ, Lee VM-Y: Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 1993, 10.1089-1099
16. Wischik CM, Novak M, Thogersen HC, Edwards PC, Runswick MJ, Jakes R, Walker JE, Milstein C, Roth M, Klug A: Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease Proc Natl Acad Sci USA 1988 85 4506-4510
17. Ksiezak-Reding H, Yen S-H Structural stability of paired helical filaments requires microtubule-binding domains of tau, a model of self-association Neuron 1991, 6.717-728
18. Wille H, Drewes G, Biernat J, Mandelkow E-M, Mandelkow E: Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro J Cell Biol 1992, 118 573-584
19. Crowther RA, Olesen OF, Smith MJ, Jakes R, Goedert M: Assembly of Alzheimer-like filaments from full-length tau protein. FEBS Lett 1994, 337:135-138
20. Masters CL, Multhaup G, Simms G, Pottgiesser J, Martins RN, Beyreuther K: Neuronal origin of a cerebral amyloid neurofibrillary tangles of Alzheimer's disease contains the same protein as the amyloid of plaque cores and blood vessels. EMBO J 1985, 4 2757-2763
21. Perry G, Cras P, Siedlak S, Tabaton M, Kawai M: β protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease. Am J Pathol 1992, 140:283-290
22. Perry G, Richey PL, Siedlak S, Smith MA, Mulvihill P, DeWitt DA, Barnett J, Greenberg BD, Kalaria RN. Immunocytochemical evidence that the β-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease. Am J Pathol 1993, 143 1586-1593
23. Mullan M, Crawford F Genetic and molecular advances in Alzheimer's disease Trends Neurosci 1993, 16:398-403
24. Shin R-W, Bramblett GT, Lee VM-Y, Trojanowski JQ. Alzheimer disease A68 proteins injected into rat brain induce co-deposits of β-amyloid, ubiquitin and α1-antichymotrypsin. Proc Natl Acad Sci USA 1993, 90. 6825-6828
25. Shin R-W, Lee VM-Y, Trojanowski JQ Aluminum modifies the properties of Alzhiemer's disease PHF-tau proteins in vivo and in vitro. J Neurosci 1994, 14:7221-7233
26. Busciglio J, Lorenzo A, Yeh J, Yankner BA. β-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 1995, 14.879-888
27. Tagliavini F, Prelli F, Verga L, Giaccone G, Sarma R, Gorevic P, Ghetti B, Passerini F, Ghibaudi E, Forloni G, Salmona M, Bugiani O, Frangione B Synthetic peptides homologous to prion protein residues 106-147 form amyloid fibrils in vitro. Proc Natl Acad Sci USA 1993, 90 9678-9682
28. Tagliavini F, Giaccone G, Prelli F, Verga L, Porro M, Trojanowski JQ, Farlow MR, Frangione B, Ghetti B, Bugiani O: A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease Indiana kindred. Brain Res 1993, 616:325-328
29. Migheli A, Autilio-Gambetti L, Gambetti P, Mocellini C, Vigliani MC, Schiffer D: Ubiquitinated filamentous inclusions in spinal cord of patients with motor neuron disease. Neurosci Lett 1990, 114:5-9
30. Herzog W, Weber K: Fractionation of brain microtubule-associated proteins: isolation of two different proteins which stimulate tubulin polymerisation in vitro Eur J Biochem 1978, 92 1-8
31. Pedrotti B, Colombo R, Islam K. Microtubule associated protein MAP1A is an actin-binding and crosslinking protein Cell Motil Cytoskeleton 1994, 29:110-116
32. Pedrotti B, Soffientini A, Islam K. Sulphonate buffers affect the recovery of microtubule-associated proteins MAP1 and MAP2 evidence that MAP1 A promotes microtubule assembly. Cell Motil Cytoskeleton 1993, 25: 234-242
33. Bondareff W, Wischik CM, Novak M, Amos WB, Klug A, Roth M: Molecular analysis of neurofibrillary degeneration in Alzheimer's disease: an immunohistochemical study Am J Pathol 1990, 137:711-723
34. Pedrotti B, Colombo R, Islam R. Interactions of microtubule-associated protein MAP2 with unpolymerized and polymerized tubulin and actin using a 96-well microtiter plate solid-phase immunoassay. Biochemistry 1994, 33.8798-8806
35. Smith MA, Siedlak SL, Richey PL, Mulvihill P, Ghiso J, Frangione B, Tagliavini F, Giaccone G, Bugiani O, Proprotnik D, Kalaria RN, Perry G: Tau protein directly interacts with the amyloid β-protein precursor implications for Alzheimer's disease Nat Med 1995, 1:365-369
36. Caputo CB, Fraser PE, Evangelista Sobel I, Kirschner DA. Amyloid-like properties of a synthetic peptide corresponding to the carboxy terminus of β-amyloid protein precursor. Arch Biochem Biophys 1992, 292 199-205
37. Caputo CB, Sygowski LA, Scott CW, Evangelista Sobel IR Role of tau in the polymerization of peptides from β-amyloid precursor protein. Brain Res 1992, 597 227-232
38. Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ: Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production Nature 1992, 360.672-674
39. 717) mutants Science 1994, 264:1336-1340
40. Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y: Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron 1994, 13 45-53
41. Hof PR, Bouras C, Buée L, Delacourte A, Perl DP, Morrison JH: Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases. Acta Neuropathol 1992, 85.23-30
42. Buée-Scherrer V, Buée L, Hof P, Leveugle B, Giles C, Loerzel AJ, Perl DP, Delacourte A. Neurofibrillary degeneration in amyotrophic lateral sclerosis/Parkinson-dementia complex of Guam immunochemical characterization of tau proteins Am J Pathol 1995, 68 924-932