On the mechanisms of the neopterin-induced suppression of renal erythropoietin production

Pteridines

Volumn 15, Issue 1, 2004, Pages 28-32

  Pagel, Horst ^a   Hoffmann, Georg ^b   Fuchs, Dietmar ^c   Schobersberger, Wolfgang ^b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY FOR HEALTH SCIENCES   (Austria)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Calcium; Erythropoetin; Neopterin; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; ERYTHROPOIETIN; NEOPTERIN; REACTIVE OXYGEN METABOLITE; VERAPAMIL;

ANIMAL TISSUE; BLOOD FLOW VELOCITY; CALCIUM CELL LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; HYPOXIA; KIDNEY; KIDNEY PERFUSION; KIDNEY VASCULAR RESISTANCE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS REGULATION; RAT; RAT STRAIN;

ANIMALIA;

EID: 2542554350     PISSN: 09334807     EISSN: 21954720     Source Type: Journal    
DOI: 10.1515/pteridines.2004.15.1.28     Document Type: Conference Paper

References (25)

1. Pagel H, Fandrey J, Schobersberger W, Fuchs D, Jelkmann W. Effects of neopterin and 7,8-dihydroneopterin on hypoxia-induced renal erythropoietin production. Eur J Haematol 1999; 62: 341-345.
2. Fuchs D, Weiss G, Reibnegger G, Wachter H. The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases. Crit Rev Clin Lab Sci 1992; 29: 307-341.
3. Agostinho P, Duarte CB, Carvalho AP, Oliveira CR. Oxidative stress affects the selective ion permeability of voltage-sensitive Ca2+ channels in cultured retinal cells. Neurosci Res 1997; 27: 323-334.
4. Hammerschmidt S, Wahn H. The effect of the oxidant hypochlorous acid on the L-type calcium current in isolated ventricular cardiomyocytes. J Mol Cell Cardiol 1998; 30: 1855-1867.
5. Hoffmann G, Gollnick F, Meyer R. Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro. Mediators Inflamm 2002; 11: 181-185.
6. Woll E, Weiss G, Fuchs D, Lang F, Wachter H. Effect of pteridine derivatives on intracellular calcium concentration in human monocytic cells. FEBS Lett 1993; 318: 249-252.
7. Faquin WC, Schneider TJ, Goldberg MA. Modulators of protein kinase C inhibit hypoxia-induced erythropoietin production. Exp Hematol 1993; 21: 420-426.
8. Metzen E, Fandrey J, Jelkmann W. Evidence against a major role for Ca2+ in hypoxia-induced gene expression in human hepatoma cells (Hep3B). J Physiol 1999; 517 (Pt 3): 651-657.
9. Pagel H, Jelkmann W, Weiss C. Isolated serum-free perfused rat kidneys release immunoreactive erythropoietin in response to hypoxia. Endocrinology 1991; 128: 2633-2638.
10. Lee GR. The anemia of chronic disease. Semin Hematol 1983; 20: 61-80.
11. Frede S, Fandrey J, Pagel H, Hellwig T, Jelkmann W. Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats. Am J Physiol 1997; 273: R1067-R1071.
12. Udupa KB, Lipschitz DA. Endotoxin-induced suppression of erythropoiesis: the role of erythropoietin and a heme synthesis stimulating factor. Blood 1982; 59: 1267-1271.
13. Jelkmann W, Wolff M, Fandrey J. Modulation of the production of erythropoietin by cytokines: in vitro studies and their clinical implications. Contrib Nephrol 1990; 87: 68-77.
14. Jelkmann W, Pagel H, Wolff M, Fandrey J. Monokines inhibiting erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys. Life Sci 1992; 50: 301-308.
15. Faquin WC, Schneider TJ, Goldberg MA. Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 1992; 79: 1987-1994.
16. Jelkmann WE, Fandrey J, Frede S, Pagel H. Inhibition of erythropoietin production by cytokines. Implications for the anemia involved in inflammatory states. Ann N Y Acad Sci 1994; 718: 300-309.
17. Fuchs D, Zangerle R, Artner-Dworzak E, Weiss G, Fritsch P, Tilz GP, et al. Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection. Eur J Haematol 1993; 50: 90-94.
18. Denz H, Huber P, Landmann R, Orth B, Wachter H, Fuchs D. Association between the activation of macrophages, changes of iron metabolism and the degree of anaemia in patients with malignant disorders. Eur J Haematol 1992; 48: 244-248.
19. Schobersberger W, Jelkmann W, Fandrey F, Frede S, Wachter H, Fuchs D, Neopterin-induced suppression of erythropoietin production in vitro. Pteridines 1995; 8: 12-16.
20. Murr C, Fuchs D, Gossler W, Hausen A, Reibnegger G, Werner ER, et al. Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes. FEBS Lett 1994; 338: 223-226.
21. Hoffmann G, Schobersberger W, Frede S, Pelzer L, Fandrey J, Wachter H, et al. Neopterin activates transcription factor nuclear factor-kappa B in vascular smooth muscle cells. FEBS Lett 1996; 391: 181-184.
22. Schobersberger W, Hoffmann G, Grote J, Wachter H, Fuchs D. Induction of inducible nitric oxide synthase expression by neopterin in vascular smooth muscle cells. FEBS Lett 1995; 377: 461-464.
23. Hoffmann G, Kenn S, Wirleitner B, Deetjen C, Frede S, Smolny M, et al. Neopterin induces nitric oxide-dependent apoptosis in rat vascular smooth muscle cells. Immunobiology 1998; 199: 63-73.
24. Schobersberger W, Hoffmann G, Hobisch-Hagen P, Bock G, Vòlkl H, Baier-Bitterlich G, et al. Neopterin and 7,8-dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2. FEBS Lett 1996; 397: 263-268.
25. Neumcke I, Schneider B, Fandrey J, Pagel H. Effects of pro- and antioxidative compounds on renal production of erythropoietin. Endocrinology 1999; 140: 641-645.