Agonist-specific regulation of Parathyroid Hormone (PTH) receptor type 2 activity: Structural and functional analysis of PTH- and Tuberoinfundibular Peptide (TIP) 39-stimulated desensitization and internalization

Molecular Endocrinology

Volumn 18, Issue 6, 2004, Pages 1486-1498

  Bisello, Alessandro ^a   Manen, Danielle ^b   Pierroz, Dominique D ^b   Usdin, Ted B ^c   Rizzoli, René ^b   Ferrari, Serge L ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; DYNAMIN; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PROTEIN; TUBEROINFUNDIBULAR PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DELETION MUTANT; DESENSITIZATION; ENZYME ACTIVITY; INTERNALIZATION; PRIORITY JOURNAL; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; ARRESTINS; CALCIUM; CELL LINE; CLONING, MOLECULAR; CYCLIC AMP; DYNAMINS; ENDOCYTOSIS; GENES, DOMINANT; GREEN FLUORESCENT PROTEINS; HUMANS; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTATION; PARATHYROID HORMONE; PEPTIDES; PLASMIDS; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTOR, PARATHYROID HORMONE, TYPE 2; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TEMPERATURE; TIME FACTORS;

EID: 2542488147     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2003-0487     Document Type: Article

References (38)

1. Luttrell LM, Lefkowitz RJ 2002 The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci 115:455-465
2. Segre G, Goldring S 1993 Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagon-like peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family. Trends Endocrinol Metab 4:309-314
3. Behar V, Pines M, Nakamoto C, Greenberg Z, Bisello A, Stueckle SM, Bessalle R, Usdin TB, Chorev M, Rosenblatt M, Suva LJ 1996 The human PTH2 receptor: binding and signal transduction properties of the stably expressed recombinant receptor. Endocrinology 137:2748-2757
4. Usdin TB, Hoare SR, Wang T, Mezey E, Kowalak JA 1999 TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Nat Neurosci 2:941-943
5. Usdin TB, Gruber C, Bonner TI 1995 Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. J Biol Chem 270:15455-15458
6. Ferrari SL, Behar V, Chorev M, Rosenblatt M, Bisello A 1999 Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves β-arrestin2. Real-time monitoring by fluorescence microscopy. J Biol Chem 274:29968-29975
7. Castro M, Dicker F, Vilardaga JP, Krasel C, Bernhardt M, Lohse MJ 2002 Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and β-arrestins. Endocrinology 143:3854-3865
8. Vilardaga JP, Frank M, Krasel C, Dees C, Nissenson RA, Lohse MJ 2001 Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein. J Biol Chem 276:33435-33443
9. Pines M, Adams AE, Stueckle S, Bessalle R, Rashti-Behar V, Chorev M, Rosenblatt M, Suva LJ 1994 Generation and characterization of human kidney cell lines stably expressing recombinant human PTH/PTHrP receptor: lack of interaction with a C-terminal human PTH peptide. Endocrinology 135:1713-1716
10. Ferrari SL, Bisello A 2001 Cellular distribution of constitutively active mutant parathyroid hormone (PTH)/PTH-related protein receptors and regulation of cyclic adenosine 3′,5′-monophosphate signaling by β-arrestin2. Mol Endocrinol 15:149-163
11. Feng X, Zhang J, Barak LS, Meyer T, Caron MG, Hannun YA 1998 Visualization of dynamic trafficking of a protein kinase C βll/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. J Biol Chem 273:10755-10762
12. Usdin TB, Bonner TI, Hoare SR 2002 The parathyroid hormone 2 (PTH2) receptor. Receptors Channels 8:211-218
13. Bisello A, Chorev M, Rosenblatt M, Monticelli L, Mierke DF, Ferrari SL 2002 Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations. J Biol Chem 277:38524-38530
14. Clark JA, Bonner TI, Kim AS, Usdin TB 1998 Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors. Mol Endocrinol 12:193-206
15. Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA 2002 Internalization determinants of the parathyroid hormone receptor differentially regulate β-arrestin/receptor association. J Biol Chem 277:8121-8129
16. Krupnick JG, Benovic JL 1998 The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 38:289-319
17. Damke H, Baba T, Warnock DE, Schmid SL 1994 Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J Cell Biol 127:915-934
18. Sneddon WB, Syme CA, Bisello A, Magyar CE, Rochdi MD, Parent JL, Weinman EJ, Abou-Samra AB, Friedman PA 2003 Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50). J Biol Chem 278:43787-43796
19. Cheung AH, Dixon RA, Hill WS, Sigal IS, Strader CD 1990 Separation of the structural requirements for agonist-promoted activation and sequestration of the β-adrenergic receptor. Mol Pharmacol 37:775-779
20. Hunyady L, Bor M, Balla T, Catt KJ 1994 Identification of a cytoplasmic Ser-Thr-Leu motif that determines agonist-induced internalization of the AT1 angiotensin receptor. J Biol Chem 269:31378-31382
21. Willins DL, Berry SA, Alsayegh L, Blackstrom JR, Sanders-Bush E, Friedman L, Roth BL 1999 Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo. Neuroscience 91:599-606
22. Bhowmick N, Narayan P, Puett D 1998 The endothelin subtype A receptor undergoes agonist- and antagonist-mediated internalization in the absence of signaling. Endocrinology 139:3185-3192
23. Roettger BF, Ghanekar D, Rao R, Toledo C, Yingling J, Pinon D, Miller LJ 1997 Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor. Mol Pharmacol 51:357-362
24. Usdin TB 2000 The PTH2 receptor and TIP39: a new peptide-receptor system. Trends Pharmacol Sci 21:128-130
25. Piserchio A, Usdin T, Mierke DF 2000 Structure of tuberoinfundibular peptide of 39 residues. J Biol Chem 275:27284-27290
26. Rolz C, Pellegrini M, Mierke DF 1999 Molecular characterization of the receptor-ligand complex for parathyroid hormone. Biochemistry 38:6397-6405
27. Dale LB, Bhattacharya M, Seachrist JL, Anborgh PH, Ferguson SS 2001 Agonist-stimulated and tonic internalization of metabotropic glutamate receptor 1a in human embryonic kidney 293 cells: agonist-stimulated endocytosis is β-arrestin1 isoform-specific. Mol Pharmacol 60:1243-1253
28. Paing MM, Stutts AB, Kohout TA, Lefkowitz RJ, Trejo J 2002 β-Arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation. J Biol Chem 277:1292-1300
29. Perry SJ, Baillie GS, Kohout TA, McPhee I, Magiera MM, Ang KL, Miller WE, McLean AJ, Conti M, Houslay MD, Lefkowitz RJ 2002 Targeting of cyclic AMP degradation to β 2-adrenergic receptors by β-arrestins. Science 298:834-836
30. Raiborg C, Rusten TE, Stenmark H 2003 Protein sorting into multivesicular endosomes. Curr Opin Cell Biol 15:446-455
31. Dicker F, Quitterer U, Winstel R, Honold K, Lohse MJ 1999 Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases. Proc Natl Acad Sci USA 96:5476-5481
32. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Nissenson RA, Shoback DM 1996 The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways. J Biol Chem 271:33382-33389
33. Eichinger A, Fiaschi-Taesch N, Massfelder T, Fritsch S, Barthelmebs M, Helwig JJ 2002 Transcript expression of the tuberoinfundibular peptide (TIP)39/PTH2 receptor system and non-PTH1 receptor-mediated tonic effects of TIP39 and other PTH2 receptor ligands in renal vessels. Endocrinology 143:3036-3043
34. Ward HL, Small CJ, Murphy KG, Kennedy AR, Ghatei MA, Bloom SR 2001 The actions of tuberoinfundibular peptide on the hypothalamo-pituitary axes. Endocrinology 142:3451-3456
35. Sugimura Y, Murase T, Ishizaki S, Tachikawa K, Arima H, Miura Y, Usdin TB, Oiso Y 2003 Centrally administered tuberoinfundibular peptide of 39 residues inhibits arginine vasopressin release in conscious rats. Endocrinology 144:2791-2796
36. Riccobene TA, Omann GM, Linderman JJ 1999 Modeling activation and desensitization of G-protein coupled receptors provides insight into ligand efficacy. J Theor Biol 200:207-222
37. Sambrook J, Fritsch EF, Maniatis T 1989 Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
38. Corpet F 1988 Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res 16:10881-10890