Posaconazole therapy of disseminated phaeohyphomycosis in a murine model

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 6, 2004, Pages 2288-2291

  Graybill, John R ^a   Najvar, Laura K ^a   Johnson, Elizabeth ^b   Bocanegra, Rosie ^a   Loebenberg, David ^c  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; POSACONAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FUNGUS; IMMUNOCOMPETENCE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NEUROPATHOLOGY; NEUROTROPISM; NONHUMAN; NUDE MOUSE; PHAEOHYPHOMYCOSIS; PRIORITY JOURNAL; SURVIVAL; WANGIELLA DERMATITIDIS;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; BRAIN; COLONY COUNT, MICROBIAL; EXOPHIALA; IMMUNOCOMPROMISED HOST; MICE; MICE, INBRED BALB C; MICE, NUDE; MYCOSES; SURVIVAL ANALYSIS; TRIAZOLES;

EID: 2542479969     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.6.2288-2291.2004     Document Type: Article

References (25)

1. Adam, R. D., M. L. Paquin, E. A. Petersen, M. A. Saubolle, M. G. Rinaldi, J. G. Corcoran, J. N. Galgiani, and R. E. Sobonya. 1986. Phaeohyphomycosis caused by the fungal generaBipolaris and Exserohilum. Medicine 65:203-217.
2. Al Abdely, H., L. Najvar, R. Bocanegra, A. Fothergill, and J. R. Graybill. 2000. SCH56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoidem ("Ramichloridium mackeniei"). Antimicrob. Agents Chemother. 44:1159-1162.
3. Colciron, B. M., E. L. Wiley, and M. G. Rinaldi. 1990. Cutaneous phaeohyphomycosis caused by a rare fungal pathogen Hormonema dematioides: successful treatment with fluconazole. J. Am. Acad. Dermatol. 23:363-367.
4. Connolly, P., L. J. Wheat, C. Schnizlein-Bick, M. Durkin, S. Kohler, M. Smedema, J. Goldberg, E. Brizendine, and D. Loebenberg. 1999. Comparison of a new triazole, pesaconazole, with itraconazole and amphotericin B for treatment of histoplasmosis in immunocompetent mice. Antimicrob. Agents Chemother. 43:322-328.
5. Connolly, P., L. J. Wheat, C. Schnizlein-Bick, M. Durkin, S. Kohler, M. Smedema, J. Goldberg, E. Brizendine, and D. Loebenberg. 2000. Comparison of a new triazole, posaconazole, with itraconazole and amphotericin B for treatment of histoplasmosis following pulmonary challenge in immunocompromised mice. Antimicrob. Agents Chemother. 44:2604-2608.
6. Dixon, D. M., and A. Polak. 1987. In vitro and in vivo drug studies with three agents of central nervous system phaeohyphomycosis. Chemotherapy 33:129-140.
7. Feng, B., X. Wang, M. Hauser, S. Kaufmann, S. Jentsch, G. Haase, J. M. Becker, and P. J. Szaniszlo. 2001. Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis. Infect. Immun. 69:1781-1794.
8. Gené, J., A. Azón-Masoliver, J. Guarro, F. Ballester, I. Pujol, M. Llovera and C. Ferrer. 1995. Cutaneous phaeohyphomycosis caused by Alternaria longipes in an immunosuppressed patient. J. Clin. Microbiol. 33:2774-2776.
9. Gonzalez, G. M., R. Tijerina, L. K. Najvar, R. Bocanegra, M. G. Rinaldi, D. Loebenberg, and J. R. Graybill. 2003. Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays. Antimicrob. Agents Chemother. 47:1436-1438.
10. Graybill, J. R. 1988. Zygomycosis and phaeohyphomycosis. In Current therapy in pediatric infectious diseases, vol, 2, p. 177-178. B. C. Deecker Inc., Philadelphia, Pa.
11. Graybill, J. R., R. Bocanegra, M. Luther, and D. Loebenberg. 1998. SCH56592 treatment of murine invasive aspergillosis. J. Antimicrob. Chemother. 42:539-542.
12. Hsu, M. M. L., and J. Y. Y. Lee. 1993. Cutaneous and subcutaneous phaeohyphomycosis caused by Exserohilum rostratum. J. Am. Acad. Dermatol. 28(Suppl.):340-344.
13. Kirkpatrick, W. R., R. K. McAtee, A. W. Fothergill, D. Loebenberg, M. G. Rinaldi, and T. F. Patterson. 2000. Efficacy of SCH56592 in a rabbit model of invasive aspergillosis. Antimicrob. Agents Chemother. 44:780-782.
14. Kotylo, P. K., K. S. Israel, J. S. Cohen, and M. S. Bartlett. 1993. Subcutaneous phaeohyphomycosis of the finger caused by Erophiala spinifera. Am. J. Clin. Pathol. 91:624-627.
15. Matsumoto, T., T. Matsuda, M. R. McGinnis, and L. Ajello. 1993. Clinical and mycological spectra of Wangiella dermatitidis infections. Mycoses 36:145-155.
16. Mukherji, S. K., and M. Castillo. 1995. Cerebral phaeohyphomycosis caused by Xylohypha bantiana: MR findings. Am. J. Roentgenol. 164:1304-1305.
17. National Committee for Clinical Laboratory Standards. 1998. Reference method for broth dilution antifungal susceptibility testing of conidium-forming filamentous fungi. Proposed standard M38-A. National Committee for Clinical Laboratory Standards, Wayne, Pa.
18. Perfect, J. R., K. A. Marr, T. J. Walsh, R. N. Greenberg, B. DuPont, J. de la Torre-Cisneros, G. Just-Nubling, H. T. Schlamm, I. Lutsar, A. Espinof-Ingroff, and E. Johnson. 2003. Voriconazole treatment for less-common, emerging, or refractory fungal infections. Clin. Infect. Dis. 36:1122-1131.
19. Rex, J. H., M. A. Pfaller, J. N. Galgiani, M. S. Bartlett, A. Espinel-Ingroff, M. A. Ghannoum, M. Lancaster, F. C. Odds, M. G. Rinaldi, T. J. Walsh, A. L. Barry, and National Committee for Clinical Laboratory Standards. 1997. Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and Candida infections. Clin. Infect. Dis. 24:235-247.
20. Rinaldi, M. G. 1996. Phaeohyphomycosis. Dermatol. Clin. 14:147-153.
21. Sharkey, P. K., J. R. Graybill, M. G. Rinaldi, D. A. Stevens, R. M. Tucker, J. D. Peterie, P. D. Hoeprich, D. L. Greer, L. Frenkel, G. W. Counts, J. Goodrich, S. Zellner, R. W. Bradsher, C. M. van der Horst, K. Israel, G. A. Pankey, and C. P. Barranco. 1990. Itraconazole treatment of phaeohyphomycosis. J. Am. Acad. Dermatol. 23:577-586.
22. Shugar, M. A., W. W. Montgomery, and N. E. Hyslop. 1981. Alternaria sinusitis. Ann. Otol. Rhinol. Laryngol. 90:251-254.
23. Sun, Q. N., L. Najvar, R. Bocanegra, D. Loebenberg, and J. R. Graybill. 2002. In vivo activity of posaconazole against Mucor spp. in an immunosup-immunosuppressed mouse model. Antimicrob. Agents Chemother. 46:2310-2312.
24. Vukmir, R. B., S. Kusne, P. Linden, W. Pasculle, A. W. Fothergill, J. Sheaffer, J. Nieto, R. Segal, H. Merhav, A. J. Martinez, and M. G. Rinaldi. 1994. Successful therapy for cerebral phaeohyphomycosis due to Dactylaria gallopava in a liver transplant recipient. Clin. Infect. Dis. 19:714-719.
25. Wiest, P. M., K. Wiese, M. R. Jacobs, A. B. Morrissey, T. I. Abelson, W. Witt, and M. M. Lederman. 1987. Alternaria infection in a patient with acquired immunodeficiency syndrome: case report and review of invasive alternaria infections. Rev. Infect. Dis. 9:799-803.