Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 21, 2005, Pages 4809-4813

  Dowling, James E ^a   Vessels, Jeffrey T ^a   Haque, Serajul ^a   He, Xi Chang ^a   Van Vloten, Kurt ^a   Kumaravel, Gnanasambandam ^a   Engber, Thomas ^a   Jin, Xiaowei ^a   Phadke, Deepali ^a   Wang, Joy ^a   Ayyub, Eman ^a   Petter, Russell C ^a  

^a BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR ANTAGONIST; PYRAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE MODEL; DRUG ACTIVITY; DRUG SYNTHESIS; IN VIVO STUDY; NONHUMAN; PARKINSON DISEASE; RAT;

ANIMALS; BRAIN; CELL MEMBRANE; DISEASE MODELS, ANIMAL; PARKINSON DISEASE; PYRAZINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 25144524190     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.07.052     Document Type: Article

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31. 6); δ 7.22 (t, J = 3.9 Hz, 1H), 7.83 (dd, J = 4.8 Hz, 1H), 7.99 (d, J = 4.1 Hz, 1H), 8.49 (s, 1H), 8.88 (br s, 1H); MS: m/z = 361 (MH+).
32. 3): δ 6.60 (dd, 1H), 7.33 (d, 1H), 7.62 (d, 1H), 8.63 (s, 1H); MS: m/z = 343 (MH+).