Parenchymal regression in chronic pancreatitis spares islets reprogrammed for the expression of NFκB and IAPs

Laboratory Investigation

Volumn 85, Issue 10, 2005, Pages 1263-1275

  Hasel, Cornelia ^a   Bhanot, Umesh K ^a   Heydrich, René ^a   Sträter, Jörn ^a   Möller, Peter ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Chronic pancreatitis; cIAPs; Fibrosis; NF B; RelA; Survivin

Indexed keywords

DEATH RECEPTOR 4; GAMMA INTERFERON; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; MESSENGER RNA; PROTEIN SUBUNIT; SURVIVIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ARTICLE; CELL LINE; CHRONIC PANCREATITIS; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE SEVERITY; DOWN REGULATION; EPITHELIUM; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULINOMA; PANCREAS ISLET; PARENCHYMA; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; EPITHELIUM; FIBROSIS; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; INHIBITOR OF APOPTOSIS PROTEINS; INSULINOMA; INTERFERON TYPE II; ISLETS OF LANGERHANS; MEMBRANE GLYCOPROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; NF-KAPPA B; PANCREATITIS, CHRONIC; PROTEIN SUBUNITS; RECEPTORS, TUMOR NECROSIS FACTOR; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR DECOY RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 25144491793     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700323     Document Type: Article

References (27)

1. Bockman DE. Morphology of the exocrine pancreas related to pancreatitis. Microsc Res Technol 1997;37:509-519.
2. Kloppel G, Maillet B. Pathology of acute and chronic pancreatitis. Pancreas 1993;8:659-670.
3. Hasel C, Rau B, Perner S, et al. Differential and mutually exclusive expression of CD95 and CD95 ligand in epithelia of normal pancreas and chronic pancreatitis. Lab Invest 2001;81:317-326.
4. Hasel C, Durr S, Rau B, et al. In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas. Lab Invest 2003;83:825-836.
5. Degli-Esposti MA, Dougall WC, Smolak PJ, et al. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 1997;7:813-820.
6. Bachem MG, Schneider E, Gross H, et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998;115:421-432.
7. Kruse ML, Hildebrand PB, Timke C, et al. TGFbeta1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro. Regul Pept 2000;90:47-52.
8. Aggarwal BB, Bhardwaj U, Takada Y. Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors. Vitam Horm 2004;67:453-483.
9. Deveraux QL, Reed JC. IAP family proteins - suppressors of apoptosis. Genes Dev 1999;13:239-252.
10. Ashkenazi A, Pai RC, Fong S, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999;104:155-162.
11. Barkett M, Gilmore TD. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 1999;18:6910-6924.
12. Schmid RM, Adler G. NF-kappaB/rel/IkappaB: implications in gastrointestinal diseases. Gastroenterology 2000;118:1208-1228.
13. Chen X, Kandasamy K, Srivastava RK. Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis factor-related apoptosis-inducing ligand signaling. Cancer Res 2003;63:1059-1066.
14. Wang Y, Cui H, Schroering A, et al. NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nat Cell Biol 2002;4:888-893.
15. Hacker H, Karin M. Is NF-kappaB2/p100 a direct activator of programmed cell death? Cancer Cell 2002;2:431-433.
16. Steinle AU, Weidenbach H, Wagner M, et al. NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology 1999;116:420-430.
17. Chen X, Ji B, Han B, et al. NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology 2002;122:448-457.
18. Weber CK, Adler G. From acinar cell damage to systemic inflammatory response: current concepts in pancreatitis. Pancreatology 2001;1:356-362.
19. Tamm I, Wang Y, Sausville E, et al. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res 1998;58:5315-5320.
20. Fulda S, Debatin KM. Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res 2004;64:337-346.
21. Satoh K, Kaneko K, Hirota M, et al. Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors. Cancer 2001;92:271-278.
22. Verhagen AM, Coulson EJ, Vaux DL. Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol 2001;2 (reviews 3009. 1-10).
23. Liggins C, Orlicky DJ, Bloomquist LA, et al. Developmentally regulated expression of survivin in human pancreatic islets. Pediatr Dev Pathol 2003;6:392-397.
24. Mi QS, Ly D, Lamhamedi-Cherradi SE, et al. Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice. Diabetes 2003;52:1967-1975.
25. Lamhamedi-Cherradi SE, Zheng S, Tisch RM, et al. Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes. Diabetes 2003;52:2274-2278.
26. Ou D, Metzger DL, Wang X, et al. TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction. Diabetologia 2002;45:1678-1688.
27. Nagata S. Apoptosis by death factor. Cell 1997;88:355-365.