Mutational analysis demonstrates that specific electrostatic interactions can play a key role in the denatured state ensemble of proteins

Journal of Molecular Biology

Volumn 353, Issue 1, 2005, Pages 174-185

  Cho, Jae Hyun ^a   Raleigh, Daniel P ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Denatured state; Electrostatic interaction; pH dependent stability change; pKa perturbation; Protein folding

Indexed keywords

ASPARTIC ACID; LYSINE; METHIONINE; MUTANT PROTEIN; PROTEIN; RIBOSOME PROTEIN; RIBOSOME PROTEIN L 9; UNCLASSIFIED DRUG;

ACIDITY; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; ELECTRICITY; GENETIC CODE; HYDROPHOBICITY; MUTATIONAL ANALYSIS; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; RANDOMIZATION; STATISTICAL SIGNIFICANCE;

EID: 25144470141     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.08.019     Document Type: Article

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