Cerebral physiology of cardiac surgical patients treated with the perfluorocarbon emulsion, AF0144

Annals of Thoracic Surgery

Volumn 80, Issue 4, 2005, Pages 1401-1407

  Hill, Steven E ^a   Grocott, Hilary P ^b   Leone, Bruce J ^b   White, William D ^b   Newman, Mark F ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AF 0144; FLUOROCARBON; PERFLUOROOCTYL BROMIDE; XENON 133;

ADULT; ARTERY CATHETERIZATION; ARTICLE; BLOOD; BLOOD VOLUME; BRAIN; BRAIN BLOOD FLOW; BRAIN EMBOLISM; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOPPLER ECHOGRAPHY; DRUG EFFECT; EMULSION; HEART SURGERY; HEMATOCRIT; HEMODILUTION; HUMAN; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

ADULT; AGED; AGED, 80 AND OVER; BODY TEMPERATURE; CARDIOPULMONARY BYPASS; CEREBROVASCULAR CIRCULATION; CORONARY ARTERY BYPASS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUOROCARBONS; HUMANS; INTRACRANIAL EMBOLISM; MALE; MIDDLE AGED; SINGLE-BLIND METHOD;

EID: 25144463046     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2005.03.107     Document Type: Article

References (26)

1. J.G. Reiss Overview of progress in the fluorocarbon approach to in vivo oxygen delivery Artif Cells Blood Substit Immobil Biotechnol 20 1992 183 202
2. D.R. Spahn, R. van Brempt, G. Theilmeier European Perflubron Emulsion Study Group Perflubron emulsion delays blood transfusions in orthopedic surgery Anesthesiology 91 1999 1195 1208
3. J.A. Wahr, A. Trouwborst, R.K. Spence A pilot study of the effects of a perflubron emulsion, AF0104, on mixed venous oxygen tension in anesthetized surgical patients Anesth Analg 82 1996 103 107
4. R.J. Noveck, E.J. Shannon, P.T. Leese Randomized safety studies of intravenous perflubron emulsion. II: Effects on immune function in healthy volunteers Anesth Analg 91 2000 812 822
5. P.T. Leese, R.J. Noveck, J.S. Shorr, C. Woods, K.E. Flaim, P.E. Keipert Randomized safety studies of intravenous perflubron emulsion. I: Effects on coagulation function in healthy volunteers Anesth Analg 91 2000 804 811
6. G.L. Bryson, A. Laupacis, G.A. Wells Does acute normovolemic hemodilution reduce perioperative allogeneic transfusion? A meta-analysis. The International Study of Perioperative Transfusion Anesth Analg 86 1998 9 15
7. R.E. Helm, J.D. Klemperer, T.K. Rosengart Intraoperative autologous blood donation preserves red cell mass but does not decrease postoperative bleeding Ann Thorac Surg 62 1996 1431 1441
8. T.G. Monk, T.S. Winston, J. Wahr Perflubron emulsion is more effective than blood for transfusion trigger reversal Anesth Analg 86 1998 S142
9. S.E. Hill, B.J. Leone, N.S. Faithfull, K.E. Flaim, P.E. Keipert, M.F. Newman Perflubron emulsion (AF0144) augments harvesting of autologous blood a phase II study in cardiac surgery J Cardiothorac Vasc Anesth 16 2002 555 560
10. D.R. Spahn, T.J. Quill, W.C. Hu Validation of 133Xe clearance as a cerebral blood flow measurement technique during cardiopulmonary bypass J Cereb Blood Flow Metab 12 1992 155 161
11. P.A. Lee, A.L. Sylvia, C.A. Piantadosi Effect of fluorocarbon-for-blood exchange on regional cerebral blood flow in rats Am J Physiol 254 1988 H719 H726
12. S. Hiraga, P. Klubes, E.S. Owens, R.L. Cysyk, R.G. Blasberg Increases in brain tumor and cerebral blood flow by blood-perfluorochemical emulsion (Fluosol-DA) exchange Cancer Res 47 1987 3296 3302
13. B.P. Wagner, R. Stingele, M.A. Williams, D.A. Wilson, R.J. Traystman, D.F. Hanley NO contributes to neurohypophysial but not other regional cerebral fluorocarbon-induced hyperemia in cats Am J Physiol 273 1997 H1994 H2000
14. B.I. Tranmer, R. Iacobacci, S. Feiler Effect of Fluosol-DA and hetastarch on local cerebral blood flow, cortical O2 availability and computerized EEG data during cerebral ischaemia Neurol Res 12 1990 17 22
15. J.C. Briceno, T.M. Runge, J.W. McGinity Changes in brain pH, PO2, PCO2, cerebral blood flow, and blood gases induced by a hyperosmolar oxyreplete hemosubstitute during cardiopulmonary bypass Asaio J 43 1997 13 18
16. C. Vocelka, B. Spiess, L. Soltow A perfluorocarbon emulsion prime additive improves the electroencephalogram and cerebral blood flow at the initiation of cardiopulmonary bypass J Extra Corpor Technol 27 1995 6 10
17. Y. Oda, T. Murata, Y. Uchida Clinical evaluation of artificial blood substitute (fluosol-DA 20%) in patients of cerebral ischemia No Shinkei Geka 10 1982 637 644
18. S. Nagasawa, H. Handa, Y. Yonekawa, Y. Oda, Y. Tsuda, K. Yokoyama Effects of a transfusion with a blood substitute (Fluosol-DA, 20%). Part II: Human cerebral blood flow Neurol Res 5 1983 19 30
19. R.P. Cochran, K.S. Kunzelman, C.R. Vocelka Perfluorocarbon emulsion in the cardiopulmonary bypass prime reduces neurologic injury Ann Thorac Surg 63 1997 1326 1332
20. J. van der Linden, L. Hadjinikolaou, P. Bergman, D. Lindblom Postoperative stroke in cardiac surgery is related to the location and extent of atherosclerotic disease in the ascending aorta J Am Coll Cardiol 38 2001 131 135
21. D.M. Moody, M.A. Bell, V.R. Challa, W.E. Johnston, D.S. Prough Brain microemboli during cardiac surgery or aortography Ann Neurol 28 1990 477 486
22. W. Pugsley, L. Klinger, C. Paschalis, T. Treasure, M. Harrison, S. Newman The impact of microemboli during cardiopulmonary bypass on neuropsychological functioning Stroke 25 1994 1393 1399
23. Alliance Pharmaceutical Corp. announces voluntary suspension of enrollment in OxygentTM phase 3 cardiac surgery study, January 08, 2001. Available at http://www.allp.com/press. Accessed February 06, 2003.
24. J.A. Novotny, B.J. Bridgewater, J.F. Himm, L.D. Homer Quantifying the effect of intravascular perfluorocarbon on xenon elimination from canine muscle J Appl Physiol 74 1993 1356 1360
25. J. Guo, J.A. White, H.H. Batjer Intravenous perflubron emulsion administration improves the recovery of auditory evoked potentials after temporary brain stem ischemia in dogs Neurosurgery 36 1995 350 356 discussion 356-7
26. R.A. Kline, W. Negendank, L. McCoy, R. Berguer Beneficial effects of isovolemic hemodilution using a perfluorocarbon emulsion in a stroke model Am J Surg 162 1991 103 106