Perfluorocarbon emulsion in the cardiopulmonary bypass prime reduces neurologic injury

Annals of Thoracic Surgery

Volumn 63, Issue 5, 1997, Pages 1326-1332

  Cochran, Richard P ^a   Kunzelman, Karyn S ^a   Vocelka, Craig R ^a   Akimoto, Hiroji ^a   Thomas, Robert ^a   Soltow, Louise O ^a   Spiess, Bruce D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROCARBON;

AIR EMBOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN INFARCTION; BRAIN INJURY; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PSYCHOMETRY; STROKE; SWINE;

ANIMALS; BRAIN; CARDIOPULMONARY BYPASS; CEREBRAL INFARCTION; ELECTROENCEPHALOGRAPHY; EMBOLISM, AIR; EMULSIONS; FLUOROCARBONS; INTRACRANIAL EMBOLISM AND THROMBOSIS; MICROSPHERES; RANDOM ALLOCATION; REGIONAL BLOOD FLOW; SWINE;

EID: 0031149210     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(97)00079-9     Document Type: Article

References (20)

1. 1. Mangano DT. Perioperative cardiac morbidity. Anesthesiology 1990;72:153-84.
2. 2. Slogoff S, Girgis KZ, Keats AZ. Etiologic factors in neuropsychiatric complications associated with cardiopulmonary bypass. Anesth Analg 1982;61:903-11.
3. 3. Shaw PH, Bates D, Cartlidge NEF, et al. Neurologic and neuropsychologic morbidity following major surgery. Comparisons of coronary artery bypass and peripheral vascular surgery. Stroke 1987;188:700-7.
4. 4. Smith PL, Treasure T, Neuman SP, et al. Cerebral consequences of cardiopulmonary bypass. Lancet 1986;1:823-5.
5. 5. Mills NL, Ochsner JL. Massive air embolism during cardiopulmonary bypass: causes, prevention, and management. J Thorac Cardiovasc Surg 1980;80:208-15.
6. 6. Spiess BD, McCarthy R, Piotrowski D, Ivankovich AD. Protection from venous air embolism with fluorocarbon emulsion FC-43. J Surg Res 1986;41:439-44.
7. 7. Spiess BD, Braveman B, Waroniwicz AW, Ivankovich AD. Protection from cerebral air emboli perfluorocarbons in rabbits. Stroke 1986;17:1146-9.
8. 8. Spiess BD, McCarthy RJ, Tuman KJ, Ivankovich AD. Protection from coronary air embolism by a perfluorocarbon emulsion (FC-43). J Cardiothorac Anesth 1987;1:210-5.
9. 9. Gillinov AM, Redmond JM, Zehr KJ, et al. Inhibition of neutrophil adhesion during cardiopulmonary bypass. Ann Thorac Surg 1994;57:126-33.
10. 10. Zehr KH, Poston RS, Lee PC, et al. Platelet activating factor inhibition reduces lung injury after cardiopulmonary bypass. Ann Thorac Surg 1995;59:328-35.
11. 11. Geyer RP. Perfluorochemicals as oxygen transport vehicles. Biomater Artif Cells Artif Org 1988;16:31-49.
12. 12. VanWoerkens LJ, Van der Giessen WY, Verdouw PD. Cardiovascular profile of 5 novel nitrate-esters: a comparative study with nitroglycerin in pigs with and without left ventricular dysfunction. Br J Pharmacol 1991; 104:7-14.
13. 13. Dettmers C, Hartmann A, Rommel T, et al. Immersion and perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) compared to mitochondrial enzymes 6 hours after MCA occlusion in primates. Neurol Res 1994;16:205-8.
14. 14. Blauth C, Griffin S, Harrison M, et al. Neuropsychologic alterations after cardiac operation. J Thorac Cardiovasc Surg 1989;98:454-9.
15. 15. Moss G. The adequacy of the cerebral collateral circulation: tolerance of awake experimental animals to acute bilateral common carotid artery occlusion. J Surg Res 1974;16:337-8.
16. 16. O'Brien RN. Diffusion coefficients of respiratory gases in a perfluorocarbon liquid. Science 1982;217:153-5.
17. 17. Lee PA, Sylvia AL, Piantadosi CA. Effect of fluorocarbon for blood exchange as regional cerebral blood flow in rats. Am J Physiol 1988;254:719-26.
18. 18. Menasché P, Pinard E, Desroches AM, et al. Fluorocarbons: a potential treatment of cerebral air embolism in open heart surgery. Ann Thorac Surg 1985;40:494-7.
19. 19. Marchbank A. Fluorocarbon emulsions. Perfusion 1995;10: 67-88.
20. 20. Dobkin B. The economic impact of stroke. Neurology 1995; 45:S6-9.