A facile synthesis of new 2-carboxamido-3-carboxythiophene and 4,5,6,7-tetrahydro-2-carboxamido-3-carboxythieno[2,3-c]pyridine derivatives as potential endothelin receptors ligands

Farmaco

Volumn 60, Issue 9, 2005, Pages 711-720

  Pittalà, Valeria ^a   Modica, Maria ^a   Romeo, Giuseppe ^a   Materia, Luisa ^a   Salerno, Loredana ^a   Siracusa, Mariangela ^a   Cagnotto, Alfredo ^b   Mereghetti, Ilario ^b   Russo, Filippo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

2 Carboxamido 3 carboxythiophene derivatives; 4,5,6,7 Tetrahydrothieno 2,3 c pyridine; Endothelin receptors; G Protein coupled receptors; Hypertension

Indexed keywords

2 (BENZOYLAMINO) 4 (4 METHOXYPHENYL) 3 THIOPHENECARBOXYLIC ACID; 2 (BENZOYLAMINO) 5 PHENYL 3 THIOPHENECARBOXYLIC ACID; 2 (BENZOYLAMINO) 6 (PHENYLMETHYL) 4 ETHOXYCARBONYL 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 (BENZOYLAMINO) 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(2 METHOXYBENZOYL)AMINO] 5 PHENYL 3 THIOPHENECARBOXYLIC ACID; 2 [(2 METHOXYBENZOYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(2 METHYLBENZOYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(3 METHOXYBENZOYL)AMINO] 5 PHENYL 3 THIOPHENECARBOXYLIC ACID; 2 [(3 METHOXYBENZOYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(3 METHYLBENZOYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(3,4 DIMETHOXYBENZOYL)AMINO] 4 (4 METHOXYPHENYL) 3 THIOPHENECARBOXYLIC ACID; 2 [(3,4 DIMETHOXYBENZOYL)AMINO] 5 PHENYL 3 THIOPHENECARBOXYLIC ACID; 2 [(3,4 DIMETHOXYBENZOYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(4 ETHYLBENZOYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(4 METHOXYBENZOYL)AMINO] 4 (4 METHOXYPHENYL) 3 THIOPHENECARBOXYLIC ACID; 2 [(4 METHOXYBENZOYL)AMINO] 5 PHENYL 3 THIOPHENECARBOXYLIC ACID; 2 [(4 METHOXYBENZOYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(4 METHYLBENZOYL)AMINO] 5 PHENYL 3 THIOPHENECARBOXYLIC ACID; 2 [(4 METHYLBENZOYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(BENZO[1,3]DIOXOLE 5 CARBONYL)AMINO] 4 (4 METHOXYPHENYL) 3 THIOPHENECARBOXYLIC ACID; 2 [(BENZO[1,3]DIOXOLE 5 CARBONYL)AMINO] 5 PHENYL 3 THIOPHENECARBOXYLIC ACID; 2 [(BENZO[1,3]DIOXOLE 5 CARBONYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 2 [(PHENYLACETYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; 4 ETHOXYCARBONYL 2 [(4 METHYLBENZOYL)AMINO] 6 (PHENYLMETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXYLIC ACID; ENDOTHELIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CHO CELL; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENETIC TRANSFECTION; LIGAND BINDING; NONHUMAN; RADIOASSAY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; CHO CELLS; CRICETINAE; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PYRIDINES; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, INFRARED;

EID: 24944536619     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2005.06.005     Document Type: Article

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