Non-extractive procedure followed by LC/APCI MS/MS analysis of trimetazidine in plasma samples for assessing bioequivalence of immediate/modified release formulations

Biomedical Chromatography

Volumn 19, Issue 7, 2005, Pages 549-555

  Medvedovici, Andrei ^a,b   Albu, Florin ^b   Georgiţǎ, Cristina ^b   David, Victor ^a,b  

^a UNIVERSITY OF BUCHAREST   (Romania)

^b LaborMed Pharma SA   (Romania)

Author keywords

Acid protein precipitation; APCI MS MS detection; Bioequivalence; Immediate release; Modified release formulations; Plasma; Trimetazidine

Indexed keywords

ATMOSPHERIC IONIZATION; DRUG PRODUCTS; PROTEINS;

ACID PROTEIN PRECIPITATION; APCI MS/MS DETECTION; APCI-MS; BIOEQUIVALENCE; IMMEDIATE RELEASE; LC/APCI-MS/MS; MODIFIED RELEASE FORMULATION; MS DETECTION; PROTEIN PRECIPITATION; TRIMETAZIDINE;

ATMOSPHERIC PRESSURE;

1 (2,4,5 TRIMETHOXYBENZYL)PIPERAZINE; FORMIC ACID; METHANOL; PIPERAZINE DERIVATIVE; PROTEIN; TRIETHYLAMINE; TRIFLUOROACETIC ACID; TRIMETAZIDINE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BIOEQUIVALENCE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG FORMULATION; DRUG ISOLATION; FEMALE; FLOW RATE; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PH; PLASMA; PRECIPITATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; STANDARD; SUPERNATANT; VALIDATION PROCESS;

EID: 24944505461     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.478     Document Type: Article

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