Identification of trimetazidine metabolites in human urine and plasma

Xenobiotica

Volumn 26, Issue 2, 1996, Pages 221-228

  Jackson, P J ^a   Brownsill, R D ^a   Taylor, A R ^a   Resplandy, G ^b   Walther, B ^b   Schwietert, H R ^c  

^a Servier R and D Ltd   (United Kingdom)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c PRA International USA   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; TRIMETAZIDINE;

ADULT; ARTICLE; CLINICAL TRIAL; DRUG IDENTIFICATION; DRUG METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PLASMA; URINE;

EID: 0030006153     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259609046702     Document Type: Article

References (5)

1. MARIDONNEAU-PARINI, I., and HARPEY, C., 1985, Effect of trimetazidine on membrane damage induced by oxygen free radicals in human red cells. British Journal Clinical Pharmacology, 20, 148-151.
2. MIYAMOTO, G., SASABE, H., TOMINAGA, N., UEGAKI, N., TOMINAGA, M., and SHIMIZU, T., 1988, Metabolism of a new inotropic agent, 3,4-dihydro-6-[3,4-dimethoxybenzoyl)-1-piperazinyl]-2-(III)-quinolinone (OPC-8212) in the rat mouse, dog, monkey, and human, Xenobiotica, 18, 1143-1155.
3. SELLIER, P., AUDOUIN, P., PAYEN, B., CORONA, P., DUONG, T. C., and OURBAK, P., 1987, Acute effects of trimetazidine evaluated by exercise testing. European Journal Clinical Pharmacology, 33, 205-207.
4. TAYLOR, A., WOOD, S., PATEL, S., and CAMPBELL, D., 1982, The metabolism and kinetics of trimetazidine in human volunteers. Servier Research and Development Internal Document.
5. WALLACE, D., BREEN, M., BROWNSILL, R. D., and TAYLOR, A. R., 1991, The metabolism of trimetazidine in man. Servier Research and Development Internal Document.