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Volumn 180, Issue 4, 2005, Pages 654-663

The effects of acute tyrosine and phenylalanine depletion on spatial working memory and planning in healthy volunteers are predicted by changes in striatal dopamine levels

Author keywords

Dopamine; PET; Planning; Tyrosine depletion; Working memory

Indexed keywords

DOPAMINE; PHENYLALANINE; RACLOPRIDE; TYROSINE;

EID: 24944504297     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-004-2128-8     Document Type: Article
Times cited : (48)

References (67)
  • 1
    • 0022930826 scopus 로고
    • Parallel organization of functionally segregated circuits linking the basal ganglia and cortex
    • Alexander GE, Delong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking the basal ganglia and cortex. Annu Rev Neurosci 9:357-381
    • (1986) Annu Rev Neurosci , vol.9 , pp. 357-381
    • Alexander, G.E.1    Delong, M.R.2    Strick, P.L.3
  • 2
    • 0025613142 scopus 로고
    • Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions
    • Alexander GE, Crutcher MD, DeLong MR (1990) Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog Brain Res 85:119-146
    • (1990) Prog Brain Res , vol.85 , pp. 119-146
    • Alexander, G.E.1    Crutcher, M.D.2    DeLong, M.R.3
  • 3
    • 0029014326 scopus 로고
    • Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: The effects of quinpirole on memory and motor performance in monkeys
    • Arnsten AF, Cai JX, Steere JC, Goldman-Rakic PS (1995) Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys. J Neurosci 15:3429-3439
    • (1995) J Neurosci , vol.15 , pp. 3429-3439
    • Arnsten, A.F.1    Cai, J.X.2    Steere, J.C.3    Goldman-Rakic, P.S.4
  • 6
    • 0037365732 scopus 로고    scopus 로고
    • Risky business: Emotion, decision-malting, and addiction
    • Bechara A (2003) Risky business: emotion, decision-malting, and addiction. J Gambl Stud 19:23-51
    • (2003) J Gambl Stud , vol.19 , pp. 23-51
    • Bechara, A.1
  • 7
    • 84987469571 scopus 로고
    • The use of analogue scales in rating subjective feelings
    • Bond AJ, Lader MH (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47:211-218
    • (1974) Br J Med Psychol , vol.47 , pp. 211-218
    • Bond, A.J.1    Lader, M.H.2
  • 8
    • 0018725135 scopus 로고
    • Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey
    • Brozoski TJ, Brown RM, Rosvold HE, Goldman PS (1979) Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 205:929-932
    • (1979) Science , vol.205 , pp. 929-932
    • Brozoski, T.J.1    Brown, R.M.2    Rosvold, H.E.3    Goldman, P.S.4
  • 10
    • 0034097265 scopus 로고    scopus 로고
    • The effect of dopamine depletion from the caudate nucleus of the common marmoset (Callithrix jacchus) on tests of prefrontal cognitive function
    • Collins P, Wilkinson LS, Everitt BJ, Robbins TW, Roberts AC (2000) The effect of dopamine depletion from the caudate nucleus of the common marmoset (Callithrix jacchus) on tests of prefrontal cognitive function. Behav Neurosci 114:3-17
    • (2000) Behav Neurosci , vol.114 , pp. 3-17
    • Collins, P.1    Wilkinson, L.S.2    Everitt, B.J.3    Robbins, T.W.4    Roberts, A.C.5
  • 11
    • 0036191967 scopus 로고    scopus 로고
    • Dopaminergic modulation of high-level cognition in Parkinson's disease: The role of prefrontal cortex revealed by PET
    • Cools R, Stefanova E, Barker RA, Robbins TW, Owen AM (2002) Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of prefrontal cortex revealed by PET. Brain 125:584-594
    • (2002) Brain , vol.125 , pp. 584-594
    • Cools, R.1    Stefanova, E.2    Barker, R.A.3    Robbins, T.W.4    Owen, A.M.5
  • 12
    • 0034046481 scopus 로고    scopus 로고
    • Prefrontal cortical contributions to working memory: Evidence from event-related fMRI studies
    • D'Esposito M, Postle BR, Rypma B (2000) Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies. Exp Brain Res 133:3-11
    • (2000) Exp Brain Res , vol.133 , pp. 3-11
    • D'Esposito, M.1    Postle, B.R.2    Rypma, B.3
  • 13
    • 0036057385 scopus 로고    scopus 로고
    • Incorrect analysis of crossover trials in animal behaviour research
    • Diaz-Uriarte R (2002) Incorrect analysis of crossover trials in animal behaviour research. Anim Behav 63:815-822
    • (2002) Anim Behav , vol.63 , pp. 815-822
    • Diaz-Uriarte, R.1
  • 14
    • 24944455241 scopus 로고    scopus 로고
    • Effects of D1/D2 receptor stimulation on the short term spatial memory deficits induced by dopamine precursor depletion
    • Ellis KA, Mehta MA, Liley D, Wesnes K, Nathan PJ (2003) Effects of D1/D2 receptor stimulation on the short term spatial memory deficits induced by dopamine precursor depletion. J Psychopharmacol 17:A66
    • (2003) J Psychopharmacol , vol.17
    • Ellis, K.A.1    Mehta, M.A.2    Liley, D.3    Wesnes, K.4    Nathan, P.J.5
  • 15
    • 4544269949 scopus 로고    scopus 로고
    • Cognitive and motor effects of dopaminergic medication withdrawal in Parkinson's disease
    • Fern-Pollak L, Whone AL, Brooks DJ, Mehta MA (2004) Cognitive and motor effects of dopaminergic medication withdrawal in Parkinson's disease. Neuropsychologia 42:1917-1926
    • (2004) Neuropsychologia , vol.42 , pp. 1917-1926
    • Fern-Pollak, L.1    Whone, A.L.2    Brooks, D.J.3    Mehta, M.A.4
  • 17
    • 0029041296 scopus 로고
    • Are the frontal lobes implicated in "planning" functions? Interpreting data from the Tower of Hanoi
    • Goel V, Grafman J (1995) Are the frontal lobes implicated in "planning" functions? Interpreting data from the Tower of Hanoi. Neuropsychologia 33:623-642
    • (1995) Neuropsychologia , vol.33 , pp. 623-642
    • Goel, V.1    Grafman, J.2
  • 18
    • 0000292303 scopus 로고
    • Circuitry of primate prefrontal cortex and regulation of behaviour by representational memory
    • Plum F (ed). American Physiological Society, Bethesda, MD
    • Goldman-Rakic PS (1987) Circuitry of primate prefrontal cortex and regulation of behaviour by representational memory. In: Plum F (ed) Handbook of physiology; nervous system, Vol. 5. Higher functions of the brain (part 1). American Physiological Society, Bethesda, MD, pp 373-417
    • (1987) Handbook of Physiology; Nervous System, Vol. 5. Higher Functions of the Brain (Part 1) , vol.5 , pp. 373-417
    • Goldman-Rakic, P.S.1
  • 19
    • 0023877536 scopus 로고
    • 'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa
    • Gotham AM, Brown RG, Marsden CD (1988) 'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa. Brain 111:299-321
    • (1988) Brain , vol.111 , pp. 299-321
    • Gotham, A.M.1    Brown, R.G.2    Marsden, C.D.3
  • 22
    • 0017166364 scopus 로고
    • Factor analysis of analogue scales measuring subjective feelings before and after sleep
    • Herbert M, Johns MW, Dore C (1976) Factor analysis of analogue scales measuring subjective feelings before and after sleep. Br J Med Psychol 49:373-379
    • (1976) Br J Med Psychol , vol.49 , pp. 373-379
    • Herbert, M.1    Johns, M.W.2    Dore, C.3
  • 23
    • 0037233049 scopus 로고    scopus 로고
    • Cognitive effects of the dopamine receptor agonist pergolide
    • Kimberg DY, D'Esposito M (2003) Cognitive effects of the dopamine receptor agonist pergolide. Neuropsychologia 41:1020-1027
    • (2003) Neuropsychologia , vol.41 , pp. 1020-1027
    • Kimberg, D.Y.1    D'Esposito, M.2
  • 24
    • 0030662550 scopus 로고    scopus 로고
    • Effects of bromocriptine on human subjects depends on working memory capacity
    • Kimberg DY, D'Esposito M, Farah MJ (1997) Effects of bromocriptine on human subjects depends on working memory capacity. NeuroReport 8:3581-3585
    • (1997) NeuroReport , vol.8 , pp. 3581-3585
    • Kimberg, D.Y.1    D'Esposito, M.2    Farah, M.J.3
  • 25
    • 0035077794 scopus 로고    scopus 로고
    • Cortical effects of bromocriptine, a D-2 dopamine receptor agonist, in human subjects, revealed by fMRI
    • Kimberg DY, Aguirre GK, Lease J, D'Esposito M (2001) Cortical effects of bromocriptine, a D-2 dopamine receptor agonist, in human subjects, revealed by fMRI. Hum Brain Mapp 12:246-257
    • (2001) Hum Brain Mapp , vol.12 , pp. 246-257
    • Kimberg, D.Y.1    Aguirre, G.K.2    Lease, J.3    D'Esposito, M.4
  • 26
    • 0026534848 scopus 로고
    • L-Dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction
    • Lange KW, Robbins TW, Marsden CD, James M, Owen AM, Paul GM (1992) L-Dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction. Psychopharmacology 107:394-404
    • (1992) Psychopharmacology , vol.107 , pp. 394-404
    • Lange, K.W.1    Robbins, T.W.2    Marsden, C.D.3    James, M.4    Owen, A.M.5    Paul, G.M.6
  • 27
  • 28
    • 0030905562 scopus 로고    scopus 로고
    • Dopaminergic modulation of working memory for spatial but not object cues in normal volunteers
    • Luciana M, Collins PF (1997) Dopaminergic modulation of working memory for spatial but not object cues in normal volunteers. J Cogn Neurosci 9:330-347
    • (1997) J Cogn Neurosci , vol.9 , pp. 330-347
    • Luciana, M.1    Collins, P.F.2
  • 30
    • 0031968598 scopus 로고    scopus 로고
    • Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions
    • Luciana M, Collins PF, Depue RA (1998) Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions. Cereb Cortex 8:218-226
    • (1998) Cereb Cortex , vol.8 , pp. 218-226
    • Luciana, M.1    Collins, P.F.2    Depue, R.A.3
  • 33
    • 1042277053 scopus 로고    scopus 로고
    • The effects of tyrosine depletion in normal healthy volunteers: Implications for unipolar depression
    • McLean A, Rubinsztein JS, Robbins TW, Sahakian BJ (2004) The effects of tyrosine depletion in normal healthy volunteers: implications for unipolar depression. Psychopharmacology 171:286-297
    • (2004) Psychopharmacology , vol.171 , pp. 286-297
    • McLean, A.1    Rubinsztein, J.S.2    Robbins, T.W.3    Sahakian, B.J.4
  • 34
    • 0033370114 scopus 로고    scopus 로고
    • Comparison of the effects of alpha-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo
    • McTavish SF, Callado L, Cowen PJ, Sharp T (1999a) Comparison of the effects of alpha-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo. J Psychopharmacol 13:379-384
    • (1999) J Psychopharmacol , vol.13 , pp. 379-384
    • McTavish, S.F.1    Callado, L.2    Cowen, P.J.3    Sharp, T.4
  • 35
    • 0032899762 scopus 로고    scopus 로고
    • Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release
    • Berl
    • McTavish SF, Cowen PJ, Sharp T (1999b) Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release. Psychopharmacology (Berl) 141:182-188
    • (1999) Psychopharmacology , vol.141 , pp. 182-188
    • McTavish, S.F.1    Cowen, P.J.2    Sharp, T.3
  • 36
    • 0033066324 scopus 로고    scopus 로고
    • Attenuation of some subjective effects of amphetamine following tyrosine depletion
    • McTavish SF, McPherson MH, Sharp T, Cowen PJ (1999c) Attenuation of some subjective effects of amphetamine following tyrosine depletion. J Psychopharmacol 13:144-147
    • (1999) J Psychopharmacol , vol.13 , pp. 144-147
    • McTavish, S.F.1    McPherson, M.H.2    Sharp, T.3    Cowen, P.J.4
  • 37
    • 0035919530 scopus 로고    scopus 로고
    • Tyrosine depletion attenuates the behavioural stimulant effects of amphetamine and cocaine in rats
    • McTavish SF, Raumann B, Cowen PJ, Sharp T (2001) Tyrosine depletion attenuates the behavioural stimulant effects of amphetamine and cocaine in rats. Eur J Pharmacol 424:115-119
    • (2001) Eur J Pharmacol , vol.424 , pp. 115-119
    • McTavish, S.F.1    Raumann, B.2    Cowen, P.J.3    Sharp, T.4
  • 38
    • 0032861536 scopus 로고    scopus 로고
    • Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson's disease
    • Berl
    • Mehta MA, Sahakian BJ, McKenna PJ, Robbins TW (1999) Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson's disease. Psychopharmacology (Berl) 146:162-174
    • (1999) Psychopharmacology , vol.146 , pp. 162-174
    • Mehta, M.A.1    Sahakian, B.J.2    McKenna, P.J.3    Robbins, T.W.4
  • 39
    • 0003064127 scopus 로고    scopus 로고
    • Comparative psychopharmacology of methylphenidate and related drugs in human volunteers, patients with AD/HD and experimental animals
    • Solanto MV, Arnsten AFT, Castellanos FX (eds). Oxford University Press, New York
    • Mehta MA, Sahakian BJ, Robbins TW (2001a) Comparative psychopharmacology of methylphenidate and related drugs in human volunteers, patients with AD/HD and experimental animals. In: Solanto MV, Arnsten AFT, Castellanos FX (eds) Stimulant drugs and AD/HD: basic and clinical neuroscience. Oxford University Press, New York, pp 303-331
    • (2001) Stimulant Drugs and AD/HD: Basic and Clinical Neuroscience , pp. 303-331
    • Mehta, M.A.1    Sahakian, B.J.2    Robbins, T.W.3
  • 40
    • 0036136489 scopus 로고    scopus 로고
    • Improved short-term spatial memory but impaired reversal learning following the dopamine D2 agonist bromocriptine in human volunteers
    • Berl
    • Mehta MA, Swainson R, Ogilvie AD, Sahakian J, Robbins TW (2001b) Improved short-term spatial memory but impaired reversal learning following the dopamine D2 agonist bromocriptine in human volunteers. Psychopharmacology (Berl) 159:10-20
    • (2001) Psychopharmacology , vol.159 , pp. 10-20
    • Mehta, M.A.1    Swainson, R.2    Ogilvie, A.D.3    Sahakian, J.4    Robbins, T.W.5
  • 41
    • 0345734361 scopus 로고    scopus 로고
    • Systemic sulpiride modulates striatal blood flow: Relationships to spatial working memory and planning
    • Mehta MA, McGowan S, Lawrence AD, Aitken MFR, Montgomery AJ, Grasby PM (2003) Systemic sulpiride modulates striatal blood flow: relationships to spatial working memory and planning. Neuroimage 20:1982-1994
    • (2003) Neuroimage , vol.20 , pp. 1982-1994
    • Mehta, M.A.1    McGowan, S.2    Lawrence, A.D.3    Aitken, M.F.R.4    Montgomery, A.J.5    Grasby, P.M.6
  • 42
    • 4544384163 scopus 로고    scopus 로고
    • Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D(2) receptor antagonist sulpiride in human volunteers
    • Berl (in press)
    • Mehta MA, Manes FF, Magnolfi G, Sahakian BJ, Robbins TW (2004) Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D(2) receptor antagonist sulpiride in human volunteers. Psychopharmacology (Berl) (in press)
    • (2004) Psychopharmacology
    • Mehta, M.A.1    Manes, F.F.2    Magnolfi, G.3    Sahakian, B.J.4    Robbins, T.W.5
  • 43
    • 12444262185 scopus 로고    scopus 로고
    • Sulpiride and mnemonic function: Effects of a dopamine D2 receptor antagonist on working memory, emotional memory and long-term memory in healthy volunteers
    • Mehta MA, Hinton EC, Montgomery AJ, Bantick RA, Grasby PM (2005) Sulpiride and mnemonic function: effects of a dopamine D2 receptor antagonist on working memory, emotional memory and long-term memory in healthy volunteers. J Psychopharmacol 19:31-40
    • (2005) J Psychopharmacol , vol.19 , pp. 31-40
    • Mehta, M.A.1    Hinton, E.C.2    Montgomery, A.J.3    Bantick, R.A.4    Grasby, P.M.5
  • 44
    • 0022485782 scopus 로고
    • Catecholamine synthesis: Physiological coupling to precursor supply
    • Milner JD, Wurtman RJ (1986) Catecholamine synthesis: physiological coupling to precursor supply. Biochem Pharmacol 35:875-881
    • (1986) Biochem Pharmacol , vol.35 , pp. 875-881
    • Milner, J.D.1    Wurtman, R.J.2
  • 45
    • 0642340717 scopus 로고    scopus 로고
    • Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: An [11C]raclopride PET study
    • Montgomery AJ, McTavish SFB, Cowen PJ, Grasby PM (2003) Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [11C]raclopride PET study. Am J Psychiatry 160:1887-1889
    • (2003) Am J Psychiatry , vol.160 , pp. 1887-1889
    • Montgomery, A.J.1    McTavish, S.F.B.2    Cowen, P.J.3    Grasby, P.M.4
  • 46
    • 2642699960 scopus 로고    scopus 로고
    • D1- Versus D2-receptor modulation of visuospatial working memory in humans
    • Müller U, von Cramon DY, Pollmann S (1998) D1- versus D2-receptor modulation of visuospatial working memory in humans. J Neurosci 18:2720-2728
    • (1998) J Neurosci , vol.18 , pp. 2720-2728
    • Müller, U.1    Von Cramon, D.Y.2    Pollmann, S.3
  • 48
    • 0030722121 scopus 로고    scopus 로고
    • Cognitive planning in humans: Neuropsychological, neuroanatomical and neuropharmacological perspectives
    • Owen AM (1997) Cognitive planning in humans: neuropsychological, neuroanatomical and neuropharmacological perspectives. Prog Neurobiol 53:431-450
    • (1997) Prog Neurobiol , vol.53 , pp. 431-450
    • Owen, A.M.1
  • 52
    • 0033607277 scopus 로고    scopus 로고
    • Functional neuroanatomical double dissociation of mnemonic and executive control processes contributing to working memory performance
    • Postle BR, Berger JS, D'Esposito M (1999) Functional neuroanatomical double dissociation of mnemonic and executive control processes contributing to working memory performance. Proc Natl Acad Sci U S A 96:12959-12964
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12959-12964
    • Postle, B.R.1    Berger, J.S.2    D'Esposito, M.3
  • 54
    • 0035371560 scopus 로고    scopus 로고
    • Decision making and neuropsychiatry
    • Rahman S, B JS, R NC, Rogers R, Robbins T (2001) Decision making and neuropsychiatry. Trends Cogn Sci 5:271-277
    • (2001) Trends Cogn Sci , vol.5 , pp. 271-277
    • Rahman, S.1    Rogers, R.2    Robbins, T.3
  • 55
    • 0028255978 scopus 로고
    • 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: Possible interactions with subcortical dopamine
    • Roberts AC, De Salvia MA, Wilkinson LS, Collins P, Muir JL, Everitt BJ, Robbins TW (1994) 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: possible interactions with subcortical dopamine. J Neurosci 14:2531-2544
    • (1994) J Neurosci , vol.14 , pp. 2531-2544
    • Roberts, A.C.1    De Salvia, M.A.2    Wilkinson, L.S.3    Collins, P.4    Muir, J.L.5    Everitt, B.J.6    Robbins, T.W.7
  • 57
    • 0034978281 scopus 로고    scopus 로고
    • Working memory for location and time: Activity in prefrontal area 46 relates to selection rather than maintenance in memory
    • Rowe JB, Passingham RE (2001) Working memory for location and time: activity in prefrontal area 46 relates to selection rather than maintenance in memory. Neuroimage 14:77-86
    • (2001) Neuroimage , vol.14 , pp. 77-86
    • Rowe, J.B.1    Passingham, R.E.2
  • 59
    • 77956782804 scopus 로고    scopus 로고
    • The phasic reward signal of primate dopamine neurons
    • Schultz W (1998) The phasic reward signal of primate dopamine neurons. Adv Pharmacol 42:686-690
    • (1998) Adv Pharmacol , vol.42 , pp. 686-690
    • Schultz, W.1
  • 61
    • 0033951302 scopus 로고    scopus 로고
    • Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: Possible adverse effects of dopaminergic medication
    • Swainson R, Rogers RD, Sahakian BJ, Summers BA, Polkey CE, Robbins TW (2000) Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. Neuropsychologia 38:596-612
    • (2000) Neuropsychologia , vol.38 , pp. 596-612
    • Swainson, R.1    Rogers, R.D.2    Sahakian, B.J.3    Summers, B.A.4    Polkey, C.E.5    Robbins, T.W.6
  • 62
    • 0030889326 scopus 로고    scopus 로고
    • Mesoprefrontal dopaminergic neurons: Can tyrosine availability influence their functions?
    • Tam SY, Roth RH (1997) Mesoprefrontal dopaminergic neurons: can tyrosine availability influence their functions? Biochem Pharmacol 53:441-453
    • (1997) Biochem Pharmacol , vol.53 , pp. 441-453
    • Tam, S.Y.1    Roth, R.H.2
  • 63
    • 0025360205 scopus 로고
    • Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesis
    • Tam SY, D. EJ, W. BC, Roth RH (1990) Mesocortical dopamine neurons: high basal firing frequency predicts tyrosine dependence of dopamine synthesis. J Neural Transm 81:97-110
    • (1990) J Neural Transm , vol.81 , pp. 97-110
    • Tam, S.Y.1    Roth, R.H.2
  • 65
    • 0034058323 scopus 로고    scopus 로고
    • Measurement of dopamine release with continuous infusion of [11C]raclopride: Optimization and signal-to-noise considerations
    • Watabe H, Endres CJ, Breier A, Schmall B, Eckelman WC, Carson RE (2000) Measurement of dopamine release with continuous infusion of [11C]raclopride: optimization and signal-to-noise considerations. J Nucl Med 41:522-530
    • (2000) J Nucl Med , vol.41 , pp. 522-530
    • Watabe, H.1    Endres, C.J.2    Breier, A.3    Schmall, B.4    Eckelman, W.C.5    Carson, R.E.6
  • 67
    • 0032509798 scopus 로고    scopus 로고
    • Increased extracellular dopamine in the nucleus accumbens of the rat during associative learning of neutral stimuli
    • Young AM, Ahier RG, Upton RL, Joseph MH, Gray JA (1998) Increased extracellular dopamine in the nucleus accumbens of the rat during associative learning of neutral stimuli. Neuroscience 83:1175-1183
    • (1998) Neuroscience , vol.83 , pp. 1175-1183
    • Young, A.M.1    Ahier, R.G.2    Upton, R.L.3    Joseph, M.H.4    Gray, J.A.5


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