Pyrrolidinedithiocarbamate induces apoptosis in human acute myelogenous leukemic cells affecting NF-κB activity

Cancer Investigation

Volumn 23, Issue 5, 2005, Pages 404-412

  Malaguarnera, Lucia ^a,b   Pilastro, Maria Rosaria ^a   Vicari, Luisa ^a   Dimarco, Rosanna ^a   Manzella, Livia ^a   Palumbo, Giuseppe ^a   Messina, Angelo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b NONE   (Italy)

Author keywords

Acute myelogenous leukaemia (AML); Growth factors; Nuclear factor kappa B (nf B); Pyrrolidinedithiocarbamate (PDTC)

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CD34 ANTIGEN; DNA; GLUTATHIONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 3; PYRROLIDINE DITHIOCARBAMATE; SUPEROXIDE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DNA BINDING; FEMALE; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKOCYTE COUNT; MALE; OXIDATION REDUCTION REACTION; PHENOTYPE; PRIORITY JOURNAL;

ACUTE DISEASE; ADOLESCENT; ADULT; APOPTOSIS; DNA; FEMALE; HUMANS; LEUKEMIA, MYELOID; MALE; MIDDLE AGED; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN BIOSYNTHESIS; PROTEIN PRECURSORS; PYRROLIDINES; THIOCARBAMATES; TUMOR CELLS, CULTURED;

EID: 24944500395     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.1081/CNV-67147     Document Type: Article

References (35)

1. Liesivuori, J.; Savolainen, K. Dithiocarbamates. Toxicology 1994, 91 (1), 37-42.
2. Lang, J.M.; Touraine, J.L.; Trepo, C.; Choutet, P.; Kirstetter, M.; et al. Randomised, double-blind, placebo-controlled trial of ditiocarb sodium ('Imuthiol') in human immunodeficiency virus infection. Lancet 1988, 2 (8613), 702-706.
3. Nobel, C.I.; Kimland, M.; Lind, B.; Orrenius, S.; Slater, A.F. Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J. Biol. Chem. 1995, 270 (44), 26202-26208.
4. Izumi, Y.; Ogino, K.; Murata, T.; Kobayash, H.; Hobara, T. Effects of diethyldithiocarbamate on activating mechanisms of neutrophils. Pharmacol. Toxicol. 1994, 74 (4-5), 280-286.
5. Abello, P.A.; Fidler, S.A.; Bulkley, G.B.; Buchman, T.G. Antioxidants modulate induction of programmed endothelial cell death (apoptosis) by endotoxin. Arch. Surg. 1994, 129 (2), 134-140.
6. Tsai, J.C.; Jain, M.; Hsieh, C.M.; Lee, W.S.; Yoshizumi, M.; et al. Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J. Biol. Chem. 1996, 271 (7), 3667-3670.
7. Ozaki, K.; Takeda, H.; Iwahashi, H.; Kitano, S.; Hanazawz, S. NF-kappa B inhibitors stimulate apoptosis of rabbit mature osteoclasts and inhibit bone resorption by these cells. FEBS Lett. 1997, 410 (2-3), 297-300.
8. Wu, M.; Lee, H.; Bellas, R.E.; Schauer, S.L.; Arsura, M.; et al. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 1996, 15 (17), 4682-4690.
9. Porcile, C.; Stanzione, S.; Piccioli, P.; Bajetto, A.; Barbero, S.; et al. Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases. Neurochem. Int. 2003, 43 (1), 31-38.
10. Malaguarnera, L.; Quan, S.; Pilastro, M.R.; Abraham, N.G.; Kappas, A. Diminished heme oxygenase potentiates cell death: pyrrolidinedithiocarbamate mediates oxidative stress. Exp. Biol. Med. 2003, 228 (5), 459-465.
11. Malaguarnera, L.; Pilastro, M.R.; Scifo, C.; Renis, M.; Mazzarino, M.C.; Messina, A. Cell death in human acute myelogenous leukemic cells induced by pyrrolidinedithiocarbamate. Apoptosis 2003, 8 (5), 539-545.
12. Sen, C.K.; Packer, L. Antioxidant and redox regulation of gene transcription. FASEB J. 1996, 10 (7), 709-720.
13. Schreck, R.; Rieber, P.; Baeuerle, P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-κB transcription factor and HIV-1. EMBO J. 1991, 10 (8), 2247-2258.
14. Griffin, G.E.; Leung, K.; Folks, T.M.; Kunkel, S.; Nabel, G.J. Activation of HIV gene expression during differentiation by induction of NF-κB. Nature 1989, 339 (6219), 70-73.
15. Liou, H.C.; Baltimore, D. Regulation of the NF-κB/rel transcription factor and IκB inhibitor system. Curr. Opin. Cell Biol. 1993, 5 (3), 477-487.
16. Baeuerle, P.A.; Baltimore, D. I Kappa B: a specific inhibitor of the NF-κB transcription factor. Science 1988, 242 (4878), 540-546.
17. Henkel, T.; Machleidt, T.; Alkalay, I.; Kronke, M.; Ben Neriah, Y.; Baeuerle, P.A. Rapid proteolysis of IκB-α is necessary in the activation of NF-κB. Nature 1993, 365 (6442), 182-185.
18. Bernard, D.; Monte, D.; Vandenbunder, B.; Abbadie, C. The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD. Oncogene 2002, 21 (28), 4392-4402.
19. Beg, A.A.; Sha, W.C.; Bronson, R.T.; Ghosh, S.; Baltimore, D. Embryonic lethality and liver degeneration in mice lacking the Rel A component of NF-κB. Nature 1995, 376 (6536), 167-170.
20. Skorski, T.; Szczylik, C.; Ratajczal, M.Z.; Malaguanera, L.; Gewirtz, A.M.; Calabretta, B. Growth factor-dependent inhibition of normal hematopoiesis by N-ras antisense oligodeoxinucle tides. J. Exp. Med. 1992, 175 (3), 743-750.
21. Todaro, A.M.; Pafumi, C.; Perticone, G.; Munda, S.; Pilastro, M.R.; Russo, A.; Farina, M.; Messina, A. Haematopoietic progenitors from umbilical cord blood. Blood Purif. 2000, 18 (2), 144-147.
22. Kaminska, B.; Kaczmarek, L.; Malaguarnera, L.; Arcidiacono, A.; Messina, L.; Spampinato, G.; Messina, A. Transcription factor activation and functional stimulation of human monocytes. Cell Biol. Int. Rep. 1992, 16 (1), 37-45.
23. Olive, P.L.; Frazer, G.; Banath, I.P. Radiation-induced apoptosis measured in TK6 human lymphoblast cells using the comet assay. Radiat. Res. 1993, 136 (1), 130-136.
24. O'Neill, K.L.; Fairbairn, D.W.; Smith, M.J.; Poe, B.S. Critical parameters influencing hyperthermia-induced apoptosis in human lymphoid cell lines. Apoptosis 1998, 3 (5), 369-375.
25. Williams, G.T.; Smith, C.A.; Spooncer, E.; Dexter, T.M.; Taylor, D.R. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 1990, 343 (6253), 76-79.
26. Schreck, R.; Meier, B.; Männel, D.N.; Dröge, W.; Baeuerle, P.A. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J. Exp. Med. 1992, 175 (5), 1181-1194.
27. Wild, A.C.; Mulchay, R.T. Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases intracellular glutathione levels. Biochem. J. 1999, 338 (Pt. 3), 659-665.
28. Oberley, L.W. Anticancer therapy by overexpression of superoxide dismutase. Antioxid. Redox Signal. 2001, 3 (3), 461-472.
29. Mates, J.M.; Sanchez-Jimencz, F. Antioxidant enzymes and their implications in pathophysiologic processes. Front. Biosci. 1999, 4, D339-D345.
30. Schoonbroodt, S.; Piette, J. Oxidative stress interference with the nuclear factor-kappa B activation pathways. Biochem. Pharmacol. 2000, 60 (8), 1075-1083.
31. Dröge, W.; Schulze-Ostoff, K.; Mihim, S.; Galter, D.; Schenk, H.; Eck, H.P.; Roth, S.; Gmünder, H. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J. 1994, 8 (14), 1131-1138.
32. Ghosh, S.; Gifford, A.M.; Riviere, L.R.; Tempst, P.; Nolan, G.P.; Baltimore, D. Cloning of the p-50 DNA binding subunit of NF-κB. Homology to rel and dorsal. Cell 1990, 62 (5), 1019-1029.
33. Toledano, M.B.; Leonard, W.J. Modulation of transcription factor NF-κB binding activity by oxidation-reduction in vitro. Proc. Natl. Acad. Sci. U. S. A. 1991, 88 (10), 4328-4332.
34. Matthews, J.R.; Wakasugi, N.; Virelizier, J.L.; Yodoi, J.; Hay, T.R. Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 1992, 20(15), 383-3821.
35. Matthews, J.R.; Kaszubska, W.; Turcatti, G.; Wells, T.N.C.; Hay, R.T. Role of cysteine 62 in DNA recognition by the P-50 subunit of NF-kappa B. Nucleic Acids Res. 1993, 21 (8), 1727-1734.