The master regulator for entry into sporulation in Bacillus subtilis becomes a cell-specific transcription factor after asymmetric division

Genes and Development

Volumn 17, Issue 9, 2003, Pages 1166-1174

  Fujita, Masaya ^a   Losick, Richard ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Asymmetry; Bacillus subtilis; Response regulator; Sporulation; Transcription

Indexed keywords

REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SPO0A; TRANSCRIPTION FACTOR SPO0B; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; CELL DIVISION; CELL LINE; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SPORANGIUM; SPOROGENESIS; TRANSCRIPTION REGULATION;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; GENE EXPRESSION; PROMOTER REGIONS (GENETICS); SPORES, BACTERIAL; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

BACILLUS SUBTILIS; POSIBACTERIA;

EID: 0037739975     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1078303     Document Type: Article

References (33)

1. Ben-Yehuda, S. and Losick, R. 2002. Asymmetric cell division in B. subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ. Cell 109: 257-266.
2. Ben-Yehuda, S., Rudner, D.Z., and Losick, R. 2003. RacA, a bacterial protein that anchors chromosomes to the cell poles. Science 299: 532-536.
3. Burbulys, D., Trach, K.A., and Hoch, J.A. 1991. Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay. Cell 64: 545-552.
4. Burkholder, W.F., Kurtser, I., and Grossman, A.D. 2001. Replication initiation proteins regulate a developmental checkpoint in Bacillus subtilis. Cell 104: 269-279.
5. Chung, J.D., Stephanopoulos, G., Ireton, K., and Grossman, A.D. 1994. Gene expression in single cells of Bacillus subtilis: Evidence that a threshold mechanism controls the initiation of sporulation. J. Bacteriol. 176: 1977-1984.
6. Dworkin, J. and Losick, R. 2001. Differential gene expression governed by chromosomal spatial asymmetry. Cell 107: 339-346.
7. Frandsen, N., Barak, I., Karmazyn-Campelli, C., and Stragier, P. 1999. Transient gene asymmetry during sporulation and establishment of cell specificity in Bacillus subtilis. Genes Dev. 13: 394-399.
8. Fujita, M. 2000. Temporal and selective association of multiple σ factors with RNA polymerase during sporulation in Bacillus subtilis. Genes Cells 5: 79-88.
9. E in Bacillus subtilis. Mol. Microbiol. 43: 27-38.
10. Fujita, M. and Sadaie, Y. 1998. Feedback loops involving Spo0A and AbrB in in vitro transcription of the genes involved in the initiation of sporulation in Bacillus subtilis. J. Biochem. 124: 98-104.
11. Grimsley, J.K., Tjalkens, R.B., Strauch, M.A., Bird, T.H., Spiegelman, G.B., Hostomsky, Z., Whiteley, J.M., and Hoch, J.A. 1994. Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis. J. Biol. Chem. 269: 16977-16982.
12. Grossman, A.D. 1995. Genetic networks controlling the initiation of sporulation and the development of genetic competence in Bacillus subtilis. Annu. Rev. Genet. 29: 477-508.
13. Hoch, J.A. 1993. Regulation of the phosphorelay and the initiation of sporulation in Bacillus subtilis. Annu. Rev. Microbiol. 47: 441-465.
14. -. 2000. Two-component and phosphorelay signal transduction. Curr. Opin. Microbiol. 3: 165-170.
15. E is associated with its progression through three patterns of subcellular localization during sporulation in Bacillus subtilis. J. Bacteriol. 180: 2426-2433.
16. Ireton, K., Rudner, D.Z., Siranosian, K.J., and Grossman, A.D. 1993. Integration of multiple developmental signals in Bacillus subtilis through the Spo0A transcription factor. Genes Dev. 7: 283-294.
17. Jensen, R.B., Wang, S.C., and Shapiro, L. 2002. Dynamic localization of proteins and DNA during a bacterial cell cycle. Nat. Rev. Mol. Cell Biol. 3: 167-176.
18. E activation. J. Bacteriol. 170: 507-511.
19. Khvorova, A., Chary, V.K., Hilbert, D.W., and Piggot, P.J. 2000. The chromosomal location of the Bacillus subtilis sporulation gene spoIIR is important for its function. J. Bacteriol. 182: 4425-4429.
20. Levin, P.A. and Losick, R. 1996. Transcription factor Spo0A switches the localization of the cell division protein FtsZ from a medial to a bipolar pattern in Bacillus subtilis. Genes Dev. 10: 478-488.
21. Perego, M. and Hoch, J.A. 2002. Two-component systems, phosphorelays, and regulation of their activities by phosphatases. In Bacillus subtilis and its closest relatives: From genes to cells (eds. A.L Sonenshein, J.A. Hoch, and R. Losick), pp. 473-481. American Society for Microbiology, Washington, D.C.
22. Piggot, P.J. and Losick, R. 2002. Sporulation genes and intercompartmental regulation. In Bacillus subtilis and its closest relatives: From genes to cells (eds. A.L. Sonenshein, J.A. Hoch, and R. Losick), pp. 483-518. American Society for Microbiology, Washington, D.C.
23. Pogliano, J., Sharp, M.D., and Pogliano, K. 2002. Partitioning of chromosomal DNA during establishment of cellular asymmetry in Bacillus subtilis. J. Bacteriol. 184: 1743-1749.
24. Pogliano, J., Osborne, N., Sharp, M.D., Abanes-De Mello, A., Perez, A., Sun, Y.L., and Pogliano, K. 1999. A vital stain for studying membrane dynamics in bacteria: A novel mechanism controlling septation during Bacillus subtilis sporulation. Mol. Microbiol. 31: 1149-1159.
25. H. J. Bacteriol. 174: 2771-2778.
26. Rudner, D.Z., Fawcett, P., and Losick, R. 1999. A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors. Proc. Natl. Acad. Sci. 96: 14765-14770.
27. Satola, S.W., Baldus, J.M., and Moran Jr., C.P. 1992. Binding of Spo0A stimulates spoIIG promoter activity in Bacillus subtilis. J. Bacteriol. 174: 1448-1453.
28. Shapiro, L., McAdams, H.H., and Losick, R. 2002. Generating and exploiting polarity in bacteria. Science 298: 1942-1946.
29. Stragier, P. and Losick, R. 1996. Molecular genetics of sporulation in Bacillus subtilis. Annu. Rev. Genet. 30: 297-341.
30. Strauch, M.A., Wu, J.-J., Jonas, R.H., and Hoch, J.A. 1993. A positive feedback loop controls transcription of the spo0F gene, a component of the sporulation phosphorelay in Bacillus subtilis. Mol. Microbiol. 7: 967-974.
31. Wu, L.-J. and Errington, J. 1994. Bacillus subtilis spoIIIE protein required for DNA segregation during asymmetric cell division. Science 264: 572-575.
32. Youngman, P.J., Perkins, J.B., and Losick, R. 1983. Genetic transposition and insertional mutagenesis in Bacillus subtilis with Streptococcus faecalis transposon Tn917. Proc. Natl. Acad. Sci. 80: 2305-2309.
33. Zupancic, M.L., Tran, H., and Hofmeister, A.E. 2001. Chromosomal organization governs the timing of cell type-specific gene expression required for spore formation in Bacillus subtilis. Mol. Microbiol. 39: 1471-1481.