Responses of Leishmania (Viannia) braziliensis cutaneous infection to N-methylglucamine antimoniate in the rhesus monkey (macaca mulatta) model

Journal of Parasitology

Volumn 91, Issue 4, 2005, Pages 976-978

  Teva, A ^a   Porrozzi, R ^a   Oliveira Neto, M P ^b   Grimaldi Jr , G ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Funda??o Oswaldo Cruz   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

MEGLUMINE ANTIMONATE;

PARASITOLOGY;

ACUTE DISEASE; ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CHRONIC DISEASE; CRYPTIC PARASITISM; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; EXPERIMENTAL INFECTION; FEMALE; LEISHMANIA BRAZILIENSIS; LOW DRUG DOSE; MACACA; MALE; NONHUMAN; PARASITISM; PERSISTENT INFECTION; REINFECTION; RHESUS MONKEY; SKIN LEISHMANIASIS;

ANIMALS; ANTIPROTOZOAL AGENTS; DISEASE MODELS, ANIMAL; FEMALE; IMMUNITY, CELLULAR; INJECTIONS, INTRAMUSCULAR; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS, CUTANEOUS; MACACA MULATTA; MALE; MEGLUMINE; ORGANOMETALLIC COMPOUNDS;

ANIMALIA; LEISHMANIA BRAZILIENSIS; MACACA MULATTA; PRIMATES;

EID: 24944479861     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.1645/GE-3486RN.1     Document Type: Article

References (16)

1. AMARAL, V. F., V. A. O. RANSATTO, F. CONCEIÇÃO-SILVA, E. MOLINARO, V. FERREIRA, S. G. COUTINHO, D. MCMAHON-PRATT, AND G. GRIMALDI, JR. 1996. Leishmania amazonensis: The Asian rhesus macaques (Macaca mulatta) as an experimental model for study of cutaneous leishmaniasis. Experimental Parasitology 82: 34-44.
2. -, A. TEVA, R. PORROZZI, A. J. SILVA, M. S. PEREIRA, AND G. GRIMALDI, JR. 2001. Leishmania (Leishmania) major-infected rhesus macaques (Macaca mulatta) develop varying levels of resistance against homologous reinfections. Memórias do Instituto Oswaldo Cruz 96: 795-804.
3. + regulatory T cells control Leishmania major persistence and immunity. Nature 420: 502-507.
4. CROFT, S. L., AND V. YARDLEY. 2002. Chemotherapy of leishmaniasis. Current Pharmaceutical Design 8: 319-342.
5. CUPOLILLO, E., L. R. BRAHIM, C. B. TOALDO, M. P. OLIVEIRA-NETO, M. E. F. DE BRITO, A. FALQUETO, M. F. NAIFF, AND G. GRIMALDI, JR. 2003. Genetic polymorfism and molecular epidemiology of Leishmania (Viannia) braziliensis from different host and geographic areas in Brazil. Journal of Clinical Microbiology 41: 3126-3132.
6. GRIMALDI, JR., G., AND R. B. TESH. 1993. Leishmaniasis of the New World: Current concepts and implications for future research. Clinical Microbiology Reviews 6: 230-250.
7. GROGL, M., A. M. J. ODULA, L. D. C. CORDERO, AND D. E. KYLE. 1989. Leishmania spp.: Development of pentostam-resistant clones in vitro by discontinuous drug exposure. Experimental Parasitology 69: 78-90.
8. -, T. N. THOMASON, AND E. D. FRANKE. 1992. Drug resistance in leishmaniasis: Implication in systemic chemotherapy of cutaneous and mucocutaneous disease. American Journal of Tropical Medicine and Hygiene 47: 117-126.
9. KENNEDY, R. C., M. H. SHEARER, W. H. HILDEBRAND, AND R. S. SIMMONDS. 1997. Nonhuman primates and their use in immunologically based investigation. The Immunologist 5/5: 150-156.
10. MURRAY, H. W. 2000. Mononuclear cell recruitment, granuloma, assembly, and response to treatment in experimental visceral leishmaniasis: Intracellular adhesion molecule 1-dependent and -independent regulation. Infection and Immunity 11: 6294-6299.
11. NABORS, G. S., AND J. P. FARREL. 1996. Successful chemotherapy in experimental leishmaniasis is influenced by the polarity of the T-cell response before treatment. Journal of Infectious Diseases 173: 976-986.
12. OLIVEIRA-NETO, M. P., M. MATTOS, C. PIRMEZ, O. FERNANDES, S. C. GONÇALVES-COSTA, C. F. SILVA DE SOUZA, AND G. GRIMALDI, JR. 2000. Mucosal leishmaniasis ("ëspundia") responsive to low dose of N-methylglucamine (Glucantime®) in Rio de Janeiro, Brazil. Revista do Institute de Medicina Tropical de São Paulo 42: 323-327.
13. -, A. SCHUBACH, M. MATTOS, S. C. GONÇALVES-COSTA, AND C. PIRMEZ. 1997. A low-dose antimony treatment in 159 patients with American cutaneous leishmaniasis: Extensive follow-up studies (up to 10 years). American Journal of Tropical Medicine and Hygiene 57: 651-655.
14. ROMERO, G. A., M. V. GUERRA, M. G. PAES, AND V. O. MACEDO. 2001. Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: Therapeutic response to meglumine antimoniate. American Journal of Tropical Medicine and Hygiene 65: 456-465.
15. SCHUBACH A., F. HADDAD, M. P. OLIVEIRA-NETO, W. DEGRAVE, C. PIRMEZ, G. GRIMALDI, JR., AND O. FERNANDES. 1998. Detection of Leishmania DNA by polymerase chain reaction in scars of treated human patients. Journal of Infectious Diseases 178: 911-914.
16. TEVA, A., R. PORROZZI, E. CUPOLILLO, C. PIRMEZ, M. P. OLIVEIRA-NETO, AND G. GRIMALDI, JR. 2003. Leishmania (Viannia) braziliensis-induced chronic granulomatous cutaneous lesions affecting the nasal mucosa in the rhesus monkey (Macaca mulatta) model. Parasitology 127: 437-447.