Leishmania (Leishmania) major-infected Rhesus Macaques (Macaca mulatta) Develop Varying Levels of Resistance against Homologous Re-infections

Memorias do Instituto Oswaldo Cruz

Volumn 96, Issue 6, 2001, Pages 795-804

  Amaral, V F ^a   Teva, A ^a   Porrozzi, R ^b   Silva, A J ^a   Pereira, M S ^a   Oliveira Neto, M P ^c   Grimaldi Jr , G ^a  

^a Departamento de Imunologia   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c Funda??o Oswaldo Cruz   (Brazil)

Author keywords

Experimental leishmaniasis; Histopathology; Immune responses; Leishmania (L.) major; Macaca mulatta; Nonhuman primates; Rhesus macaques

Indexed keywords

ANIMALIA; LEISHMANIA MAJOR; MACACA MULATTA; PRIMATES;

GAMMA INTERFERON;

ANIMAL; ARTICLE; BIOSYNTHESIS; DELAYED HYPERSENSITIVITY; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; LEISHMANIA MAJOR; LYMPHOCYTE ACTIVATION; MACACA; MALE; PATHOLOGY; SKIN LEISHMANIASIS;

ANIMALS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYPERSENSITIVITY, DELAYED; INTERFERON TYPE II; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LYMPHOCYTE ACTIVATION; MACACA MULATTA; MALE;

EID: 0035434497     PISSN: 00740276     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0074-02762001000600010     Document Type: Article

References (48)

1. Abbas AK, Murphy KM, Sher A 1996. Functional diversity of helper T lymphocytes. Nature 383: 787-793.
2. Agwale SM, Duhlinska DD, Grimaldi Jr G 1998. Response to heterologous leishmanins in cutaneous leishmaniasis in Nigeria - Discovery of a new focus. Mem Inst Oswaldo Cruz 93: 23-27.
3. Almeida RP, Barral-Netto M, De Jesus AMR, De Freitas LAR, Carvalho EM. Barral A 1996. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/c mice. Am J Trop Med Hyg 54: 178-184.
4. Alvarado R, Enk C, Jaber K, Schur L, Frankenburg S 1989. Delayed-type hypersensitivity and lymphocyte proliferation in response to Leishmania major infection in group of children in Jericho. Trans R Soc Trop Med Hyg 83: 189-192.
5. Amaral VF, Pirmez C, Gonçalves AJS, Ferreira V, Grimaldi Jr G 2000. Cell populations in lesions of cutaneous leishmaniasis of Leishmania (L.) amazonensis-'infected rhesus macaques, Macaca mulatta. Mem Inst Oswaldo Cruz 95: 209-216.
6. Amaral VF, Ransatto VAO, Conceição-Silva F, Molinaro E, Ferreira V, Coutinho SG, McMahon-Pratt D, Grimaldi Jr G 1996. The Asian rhesus macaques (Macaca mulatta) as an experimental model for study of cutaneous leishmaniasis. Exp Parasitol 82: 4-44.
7. Anam K. Afrin F, Baneriee D, Pramanik N, Guha SK, Goswami RP. Sahaq SK, Ali N 1999. Differential decline in Leishmania membrane antigen-specific immunoglobulin G (IgG), IgM, IgE, and IgG sub-class antibodies in Indian kala-azar patients after chemotherapy. Infect Immun 67: 6663-6669.
8. Antunes CM, Mayrink W, Magalhães PA, Costa CA, Melo MN, Dias M, Michalick MS, Williams P, Lima AO, Vieira LB, Schettini APM 1986. Controlled field trials of a vaccine against New World cutaneous leishmaniasis. Int J Epidemiol 15: 572-579.
9. Beach R, Kilu G, Hendricks L, Oster C, Leeuwenberg J 1984. Cutaneous leishmaniasis in Kenya: Transmission of L. major to man by the bite of Phlebotomus duhoscqi. Trans R Soc Trop Med Hyg 78: 747-751.
10. Calvas P, Apoil P, Fortenfant F, Roubinet F, Andris J, Capra D, Blancher A 1999. Characterization of the three immunoglobulin G subclasses of macaques. Scand J Immunol 49: 595-610.
11. Carvalho EM, Johnson Jr WR, Barreto E, Marsden PD, Costa JLM, Reed S, Rocha H 1985. Cell mediated immunity in American cutaneous and mucocutaneous leishmaniasis. J Immunol 135: 4144-4148.
12. Castes M, Blackwell J, Trujillo D, Formica S, Cabrera M, Zorrilla G, Rodas A, Castellanos PL, Convit J 1994. Immune response in healthy volunteers vaccinated with killed leishmanial promastigotes plus BCG. I. Skin-test reactivity, T-cell proliferation and interferon-γ production. Vaccine 12: 1041-1051.
13. Conceição-Silva F, Dórea RC, Pirmez C, Schubach A, Coutinho SG 1990. Quantitative study of Leishmania braziliensis braziliensis reactive T cells in peripheral blood and in the lesions of patients with American mucocutaneous leishmaniasis. Clin Exp Immunol 79: 221-226.
14. Da-Cruz AM, Conceição-Silva F, Bertho AL, Coutinho SG 1994. Leishmania-reative CD4 and CD8 T cells associated with cure of human cutaneous leishmaniasis. Infect Immun 62: 2614-2618.
15. Dennis VA, Lujan R, Chapman Jr WL, Hanson WL 1986. Leishmania donovani: cellular and humoral immune responses after primary and challenge infections in squirrel monkeys, Saimiri sciureus. Exp Parasitol 61: 319-334.
16. Elassad AMS, Younis SA, Siddig M, Gravson J, Petersen E, Ghalib HW 1994. The significance of blood levels of IgM, IgA, IgG and IgG subclasses in Sudanese visceral leishmaniasis patients. Clin Exp Immunol 95: 294-299.
17. Gaafar A, Veress B, Permin H, Kharazmi A, Theander TG, El Hassan AM 1999. Characterization of the local and systemic immune responses in patients with cutaneous leishmaniasis due to Leishmania major. Clin Immunol 91: 314-320.
18. Ghosh MK, Dasgupta S, Ghose AC 1995. Immunoglobulin G sub-class-specific antileishmaniaj antibody responses in Indian kala-azar and post kala-azar dermal leishmaniasis. Clin Diagn Lab Immunol 2: 291-296.
19. Gicheru MM, Olobo JO, Anjili CO, Orago AS, Modabber F, Scott P 2001. Vervet monkeys vaccinated with killed Leishmania major parasites and interleukin-12 develop a type 1 immune response but are not protected against challenge infection. Infect Immun 69: 245-251.
20. Gicheru MM, Olobo JO, Kariuki TM, Adhiambo C 1995. Visceral leishmaniasis in vervet monkeys: Immunological responses during asymptomatic infections. Scand J Immunol 41: 202-208.
21. Githure JI, Reid GD, Binhazim AA, Anjili CO, Shatry AM, Hendricks LD 1987. Leishmania major: the suitability of East African nonhuman primates as animal models for cutaneous leishmaniasis. Exp Parasitol 64: 438-447.
22. Grimaldi Jr G, Tesh RB 1993. Leishmaniasis of the New World: current concepts and implications for future research. Clin Microbiol Rev 6: 230-250.
23. Grimaldi Jr G, Momen H, Naiff RD, McMahon-Pratt D, Barrett TV 1991. Characterization and classification of leishmanial parasites from humans, wild animals, and sand flies in the Amazon region of Brazil. Am J Trop Med Hyg 44: 645-661.
24. Gust DA, Gordon TP, Hambright MK 1993. Response to removal from and return to a social group in adult male rhesus monkeys. Physiol Behav 53: 599-602.
25. Kemp M, Hey AS, Kurtzhals JA, Christensen CB, Gaafar A, Mustafa MD, Kordofani AA, Ismail A, Kharzmi A, Theader TG 1994. Dichotomy of the human T cell response to Leishmania antigens. I. Thl-like activity response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis. Clin Exp Immunol 96: 410-415.
26. Kennedy RC, Shearer MH, Hildebrand WH 1997a. Non-human primate models to evaluate vaccine safety and immunogenicity. Vaccine 15: 903-908.
27. Kennedy RC, Shearer MH, Hildebrand WH, Simmonds RS 1997b. Nonhuman primates and their use in immunologically based investigations. The Immunologist 5/5: 150-156.
28. Kenney RT, Sacks DL, Sypek JP, Vilela L. Gam AA, Fvans-Davis K 1999. Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis. J Immunol 163: 4481-4488.
29. Killick-Kendrick R, Bryceson ADM, Peter W. Evans DA, Leaney AJ, Rioux JA 1985. Zoonotic cutaneous leishmaniasis in Saudi Arabia: Lesions healing naturally in man followed by a second infection with the same zymodeme of Leishmania major. Trans R Soc Trop Med Hyg 79: 363-365.
30. Leon LL, Barral A, Machado GMC, Grimaldi Jr G 1992. Antigenic differences among Leishmania amazonensis isolates and their relationships with distinct clinical forms of the disease. Mem Inst Oswaldo Cruz 87: 229-234.
31. Lima HC, Vasconcelos AW, David JR, Lerner EA 1994. American cutaneous leishmaniasis: in situ characterization of the cellular immune response with time. Am J Trop Med Hyg 50: 743-747.
32. Lujan R, Dennis VA, Chapman Jr WL. Hanson WL 1986. Blastogenic responses of peripheral blood leukocytes from owl monkeys experimentally infected with Leishmania braziliensis panamensis. Am J Trop Med Hyg 35: 1103-1109.
33. Olobo JO, Anjili CO, Gicheru MM, Mbati PA, Kariuki TM, Githure JI, Koech DK, McMaster WR 1995. Vaccination of vervet monkeys against cutaneous leishmaniasis using recombinant Leishmania 'major surface glycoprotein' (gp63). Vet Parasitol 60: 199-212.
34. Olobo JO, Reid GD, Githure JI, Anjili CO 1992. IFN-gamma and delayed-type hypersensitivity are associated with cutaneous leishmaniasis in vervet monkeys following secondary rechallenge with Leishmania major. Scand J Immunol (Suppl.) 11: 48-52.
35. Pirmez C, Cooper C, Paes-Oliveira M, Schubach A, Torigian VK. Modlin RL 1990. Immunologic responsiveness in American cutaneous leishmaniasis lesions. J Immunol 145: 3100-3104.
36. Pirmez C, Yamamura M, Uyemura K, Paes-Oliveira M, Conceição-Silva F, Modlin RL 1993. Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Investig 91: 1390-1395.
37. Prilliman K, Lawlor D, Ellexson M, McElwee N, Confer D, Cooper DKC, Kennedy RC, Hildebrand W 1996. Characterization of baboon class I major histocompatibility molecules. Transplantation 61: 989-996.
38. Pung OJ, Kuhn RE 1987. Experimental leishmaniasis in the Brazilian squirrel monkey (Saimiri sciureus): lesions, hematology, cellular, and humoral immune responses. J Med Primatol 16: 165-174.
39. Reed SG, Scott P 1993. T-cell and cytokine responses in leishmaniasis. Curr Opin Immunol 5: 524-531.
40. Reiner SL, Locksley RM 1995. The regulation of immunity to Leishmania major. Annu Ver Immunol 13: 151-177.
41. Richardson MD, Turner A, Warnock DW, Llewellyn PA 1983. Computer-assisted rapid enzyme-linked immunosorbent assay (ELISA) in the serological diagnosis of aspergillosis. J Immunol Methods 56: 201-207.
42. Ridley DS, Ridley MJ 1983. The evolution of the lesion in cutaneous leishmaniasis. J Pathol 141: 83-96.
43. Saravia NG, Weigle K, Segura I, Giannini SH, Pacheco R. Labrada LA, Gonçalves A 1990. Recurrent lesions in humans Leishmania braziliensis infection - Reactivation or reinfection? Lancet 336: 398-402.
44. Sassi A, Louzir H, Bem Salah A, Mokni M, Bem Osman A. Dellagi K 1999. Leishmanin skin test, lymphoproliferative responses and cytokine production after symptomatic or asymptomatic Leishmania major infection in Tunisia. Clin Exp Immunol 116: 127-132.
45. Shearer MH, Dark RD, Chodosh J, Kennedy RC 1999. Comparison and caracterization of immunoglobulin G subclasses among primate species. Clin Diagn Lab Immunol 6: 953-958.
46. Sjölander A, Baldwin TM, Curtis JM, Handman E 1998. Induction of a Thl immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis. J Immunol 160: 3949-3957.
47. Wilson HR, Dickman BS, Childs GE 1979. Leishmania braziliensis and L. mexicana mexicana: experimental cutaneous infections in golden hamsters. Exp Parasitol 47: 270-83.
48. Wolf RE 1976. Immune response to Leishmania tropica in Macaca mulatta. J Parasitol 62: 209-214.