Endocytosis and storage of plasma factor V by human megakaryocytes

Thrombosis and Haemostasis

Volumn 94, Issue 3, 2005, Pages 585-592

  Suehiro, Youko ^a   Veljkovic, Dragoslava Kika ^a   Fuller, Nola ^a   Motomura, Yasuaki ^a   Massé, Jean Marc ^b   Cramer, Elisabeth M ^b,c   Hayward, Catherine P M ^a,d  

^a MCMASTER UNIVERSITY   (Canada)

^b INSTITUT COCHIN   (France)

^c LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^d MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

Endocytosis megakaryocytes thrombopoiesis; Factor V; Factor VIII; Platelet activation markers

Indexed keywords

ALBUMIN; BINDING PROTEIN; BLOOD CLOTTING FACTOR 5; FIBRINOGEN; IMMUNOGLOBULIN G; MESSENGER RNA; MULTIMERIN 1; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL GRANULE; COMPLEX FORMATION; CONTROLLED STUDY; CULTURE MEDIUM; ELECTRON MICROSCOPY; ENDOCYTOSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MEGAKARYOCYTE; NORMAL HUMAN; PLASMA FACTOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT;

EID: 24944474010     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH05-02-0141     Document Type: Article

References (43)

1. Mann KG, Kalafatis M. Factor V: a combination of Dr Jekyll and Mr Hyde. Blood 2003; 101: 20-30.
2. Tracy PB, Eide LL, Bowie EJ et al. Radioimmunoassay of factor V in human plasma and platelets. Blood 1982; 60: 59-63.
3. Hayward CP, Furmaniak-Kazmierczak E, Cieutat AM et al. Factor V is complexed with multimerin in resting platelet lysates and colocalizes with multimerin in platelet alpha-granules. J Biol Chem 1995; 270: 19217-24.
4. Hayward CP, Fuller N, Zheng S et al. Human platelets contain forms of factor V in disulfide-linkage with multimerin. Thromb Haemost 2004; 92:1349-57.
5. Jeimy SB, Woram RA, Fuller N et al. Identification of the MMRNI binding region within the C2 domain of human factor V. J Biol Chem 2004; 279: 51466-71.
6. Gould WR, Silveira JR, Tracy PB. Unique in vivo modifications of coagulation factor V produce a physically and functionally distinct platelet-derived cofactor: characterization of purified platelet-derived factor V/Va. J Biol Chem 2004; 279: 2383-93.
7. Monkovic DD, Tracy PB. Functional characterization of human platelet-released factor V and its activation by factor Xa and thrombin. J Biol Chem 1990; 265: 17132-40.
8. Chesney CM, Pifer D, Colman RW. Subcellular localization and secretion of factor V from human platelets. Proc Natl Acad Sci U S A 1981; 78: 5180-4.
9. Cui J, O'Shea KS, Purkayastha A et al. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature 1996; 384: 66-8.
10. Sun H, Yang TL, Yang A et al. The murine platelet and plasma factor V pools are biosynthetically distint and sufficient for minimal hemostasis. Blood 2003; 102:2856-61.
11. Yang TL, Pipe SW, Yang A et al. Biosynthetic origin and functional significance of murine platelet factor V Blood 2003; 102: 2851-5.
12. Chediak J, Ashenhurst JB, Garlick I et al. Successful management of bleeding in a patient with factor V inhibitor by platelet transfusions. Blood 1980; 56: 835-41.
13. Borchgrevink CF and Owren PA. The hemostatic effect of normal platelets in hemophilia and factor V deficiency. The importance of clotting factors adsorbed on platelets for normal hemostasis. Acta Med Scand 1961; 170: 375-83.
14. Nesheim ME, Nichols WL, Cole TL et al. Isolation and study of an acquired inhibitor of human coagulation factor V. J Clin Invest 1986; 77: 405-15.
15. Weiss HJ, Lages B, Zheng S et al. Platelet factor V New York: a defect in factor V distinct from that in factor V Quebec resulting in impaired prothrombinase generation. Am J Hematol 2001; 66: 130-9.
16. Wilson DB, Salem HH, Mruk JS et al. Biosynthesis of coagulation Factor V by a human hepatocellular carcinoma cell line. J Clin Invest 1984; 73: 654-8.
17. Mazzorana M, Baffet G, Kneip B et al. Expression of coagulation factor V gene by normal adult human hepatocytes in primary culture. Br J Haematol 1991; 78: 229-35.
18. Handagama PJ, Shuman MA, Bainton DF. Incorporation of intravenously injected albumin, immunoglobulin G, and fibrinogen in guinea pig megakaryocyte granules. J Clin Invest 1989; 84: 73-82.
19. Harrison P, Wilbourn B, Debili N et al. Uptake of plasma fibrinogen into the alpha granules of human megakaryocytes and platelets. J Clin Invest 1989; 84: 1320-4.
20. Camire RM, Pollak ES, Kaushansky K et al. Secretable human platelet-derived factor V originates from the plasma pool. Blood 1998; 92: 3035-41.
21. Handagama P, Rappolee DA, Werb Z et al. Platelet alpha-granule fibrinogen, albumin, and immunoglobulin G are not synthesized by rat and mouse megakaryocytes. J Clin Invest 1990; 86: 1364-8.
22. Christella M, Thomassen LG, Castoldi E et al. Endogenous factor V synthesis in megakaryocytes contributes negligibly to the platelet factor V pool. Haematologica 2003; 88: 1150-6.
23. Veljkovic DK, Cramer EM, Alimardani G et al. Studies of alpha-granule proteins in cultured human megakaryocytes. Thromb Haemost 2003; 90: 844-52.
24. Chiu HC, Schick PK, Colman RW. Biosynthesis of factor V in isolated guinea pig megakaryocytes. J Clin Invest 1985; 75: 339-46.
25. Gewirtz AM, Keefer M, Doshi K et al. Biology of human megakaryocyte factor V. Blood 1986; 67: 1639-48.
26. Gewirtz AM, Shapiro C, Shen YM et al. Cellular and molecular regulation of factor V expression in human megakaryocytes. J Cell Physiol 1992; 153: 277-87.
27. Giampaolo A, Vulcano F, Macioce G et al. Factor-V expression in platelets from human megakaryocytic culture. Br J Haematol 2005; 128: 108-11.
28. Hayward CP, Weiss HJ, Lages B et al. The storage defects in grey platelet syndrome and alphadelta-storage pool deficiency affect alpha-granule factor V and multimerin storage without altering their proteolytic processing. Br J Haematol 2001; 113: 871-7.
29. Hayward CP, Rivard GE, Kane WH et al. An autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen and an epinephrine aggregation defect. Blood 1996; 87: 4967-78.
30. Kahr WH, Zheng S, Sheth PM et al. Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator. Blood 2001; 98: 257-65.
31. Motomura Y, Kanbayashi H, Khan WI et al. The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-{beta} type II receptor gene transfer. Am J Physiol Gastrointest Liver Physiol 2005; 288: G143-G150.
32. Hughes M, Hayward CP, Horsewood P et al. Measurement of endogenous and exogenous alpha-granular platelet proteins in patients with immune and nonimmune thrombocytopenia. Br J Haematol 1999; 106: 762-70.
33. Hayward CP, Cramer EM, Song Z et al. Studies of multimerin in human endothelial cells. Blood 1998; 91: 1304-17.
34. Hayward CP, Smith JW, Horsewood P et al. p-155, a multimeric platelet protein that is expressed on activated platelets. J Biol Chem 1991; 266: 7114-20.
35. Mattia G, Vulcano F, Milazzo L et al. Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release. Blood 2002; 99: 888-97.
36. Camire RM, Kalafatis M, Simioni P et al. Platelet-derived factor Va/Va Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C. Blood 1998; 91: 2818-29.
37. Camire RM, Kalafatis M, Cushman M et al. The mechanism of inactivation of human platelet factor Va from normal and activated protein C-resistant individuals. J Biol Chem 1995; 270: 20794-800.
38. Gould WR, Simioni P, Silveira JR et al. Megakaryo-cytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactor. J Thromb Haemost 2005; 3: 450-6.
39. Bouchard BA, Williams JL, Meisler NT et al. Endocytosis of plasma-derived factor V by megakaryocytes occurs via a clathrin-dependent, specific membrane binding event. J Thromb Haemost 2005; 3: 541-51.
40. Hoffman M. One more way that mice and men are different. J Thromb Haemost 2005; 3: 448-9.
41. Handagama P, Scarborough RM, Shuman MA et al. Endocytosis of fibrinogen into megakaryocyte and platelet alpha-granules is mediated by alpha IIb beta 3 (glycoprotein IIb-IIIa). Blood 1993; 82: 135-8.
42. Handagama P, Bainton DF, Jacques Y et al. Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules. J Clin Invest 1993; 91: 193-200.
43. Taylor VL, Spencer EM. Characterisation of insulin-like growth factor-binding protein-3 binding to a novel receptor on human platelet membranes. J Endocrinol 2001; 168: 307-15.