Human platelets contain forms of factor V in disulfide-linkage with multimerin

Thrombosis and Haemostasis

Volumn 92, Issue 6, 2004, Pages 1349-1357

  Hayward, Catherine P M ^a,b,c   Fuller, Nola ^a,b   Zheng, Shilun ^a,b   Adam, Frédéric ^a,b   Jeimy, Samira B ^a,b   Horsewood, Ian ^a,b   Quinn Allen, Mary Ann ^a,b   Kane, William H ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

Alpha granule proteins; Coagulation; Factor V; Multimerin; Platelets

Indexed keywords

BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5A; CELL PROTEIN; CYSTEINE; DETERGENT; DIMER; DISULFIDE; MULTIMERIN; POLYMER; SODIUM CHLORIDE; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DATA ANALYSIS; DISULFIDE BOND; EXPERIMENTATION; GEL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MODULATION; MOLECULAR SIZE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SECRETION; THROMBOCYTE; THROMBOCYTE ACTIVATION;

BLOOD PLATELETS; BLOOD PROTEINS; BLOTTING, WESTERN; CELL MOVEMENT; DIMERIZATION; DISULFIDES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPE MAPPING; EPITOPES; FACTOR V; FACTOR VA; GLYCOPROTEINS; HUMANS; IMMUNOPRECIPITATION; MODELS, BIOLOGICAL; POLYMERS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SECRETORY VESICLES; THROMBIN;

EID: 10444286053     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH03-02-0123     Document Type: Article

References (32)

1. Kane WH, Davie EW. Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders. Blood 1988; 71: 539-55,
2. Mann KG, Kalafatis M. Factor V: a combination of Dr. Jekyll and Mr. Hyde. Blood 2003; 101: 20-30.
3. Cui J, O'Shea S, Purkayastha A, et al. Fatal hemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature 1996; 384: 66-8.
4. Miletich JP, Majerus DW, Majerus PW. Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets. J Clin Invest 1978; 62: 824-31.
5. Guasch JF, Cannegieter S, Reitsma PH, et al. Severe coagulation factor V deficiency caused by a 4 bp deletion in the factor V gene. Br J Haematol 1998; 101: 32-9.
6. Chediak J, Ashenhurst JB, Garlick I, et al. Successful management of bleeding in a patient with factor V inhibitor by platelet transfusions. Blood 1980; 56: 835-41.
7. Borchgrevink CF, Owren PA. The hemostatic effect of normal platelets in hemophilia and factor V deficiency: the importance of clotting factors adsorbed on platelets for normal hemostasis. Acta Med Scand 1961; 170: 375-83.
8. Nesheim ME, Nichols WL, Cole TL, et al. Isolation and study of an acquired inhibitor of human coagulation factor V. J Clin Invest 1986; 77: 405-15.
9. Cripe LD, Moore KD, Kane WH. Structure of the gene for human coagulation factor V. Biochemistry 1992; 31: 3777-85.
10. Viskup RW, Tracy PB, Mann KG. Isolation of human platelet factor V. Blood 1987; 69: 1188-95.
11. Gould WR, Silveira JR, Tracy PB. Unique in vivo modifications of coagulation factor V produce a physically and functionally distinct platelet-derived cofactor: characterization of purified platelet-derived factor V/Va. J Biol Chem 2004; 279: 2383-93.
12. Hayward CPM, Furmaniak-Kazmierczak E, Cieutat A-M, et al. Factor V is complexed with multimerin in resting platelet lysates and colocalizes with multimerin in platelet α-granules. J Biol Chem 1995; 270: 19217-24.
13. Hayward CPM. Multimerin: a bench to bed-side chronology of a unique platelet and endothelial cell protein - from discovery to function to abnormalities in disease. Clin Invest Med 1997; 20: 176-87.
14. Hayward CPM, Weiss HJ, Lages B, et al. The storage defects in grey platelet syndrome and αδ-storage pool deficiency affect α-granule factor V and multimerin storage without altering their proteolytic processing. Br J Haematol 2001; 113: 871-7.
15. Hayward CPM, Rivard GE, Kane WH, et al. An autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen and an epinephrine aggregation defect. Blood 1996; 87: 4967-78.
16. Hayward CPM, Smith JW, Horsewood P, et al. P-155, a multimeric platelet protein that is expressed on activated platelets. J Biol Chem 1991; 266: 7114-20.
17. Kahr WHA, Zheng S, Sheth PM, et al. Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase type plasminogen activator. Blood 2001; 98: 257-65.
18. Riddles PW, Blakeley RL, Zerner B. Reassessment of Ellman's reagent. Methods Enzymol 1983; 91: 49-60.
19. Srivastava A, Quinn-Allen MA, Kim SW, et al. Soluble phosphatidylserine binds to a single identified site in the C2 domain of human factor Va. Biochemistry 2001; 40: 8246-55.
20. Harlow E, Lane D. Antibodies: A Laboratory Manual. Cold Spring Harbor, Cold Spring Harbor Laboratory; 1988.
21. Horsewood P, Hayward CP, Warkentin TE, et al. Investigation of the mechanisms of monoclonal antibody-induced platelet activation. Blood 1991; 78: 1019-26.
22. Hayward CPM, Song Z, Zheng S, et al. Multimerin processing by cells with and without pathways for regulated protein secretion. Blood 1999; 94: 1337-47.
23. Hayward CPM, Warkentin TE, Horsewood P, et al. Multimerin: a series of large, disulfide-linked multimeric proteins within platelets. Blood 1991; 77: 2556-60.
24. Kane WH, Ichinose A, Hagen FS, et al. Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats. Biochemistry 1987; 26: 6508-14.
25. Jenny RJ, Pittman DD, Toole JJ, et al. Complete cDNA and derived amino acid sequence of human factor V. Proc Natl Acad Sci 1987; 84: 4846-50.
26. Mannucci PM. Platelet von Willebrand factor in inherited and acquired bleeding disorders. Proc Natl Acad Sci 1995; 92: 2428-32.
27. Monkovic DD, Tracy PB. Functional characterization of human platelet-released factor V and and its activation by factor Xa and thrombin. J Biol Chem 1990; 265: 17132-40.
28. Essex DW, Chen K, Swiatkowska M. Localization of protein disulfide isomerase to the external surface platelet membrane. Blood 1995; 86: 2168-73.
29. Thorelli E, Kaufman RJ, Dahlback B. The C-terminal region of the factor V BD is crucial for the anticoagulant activity of factor V. J Biol Chem 1998; 273: 16140-5.
30. Guinto ER, Esmon CT, Mann KG, et al. complete cDNA sequence of bovine coagulation factor V. J Biol Chem 1992; 267: 2971-8.
31. Yang TL, Cui J, Rehumtulla A, et al. The structure and function of murine factor V and its inactivation by protein C. Blood 1998; 91: 4593-9.
32. Wyshock EG, Stewart GJ, Colman RW. Thrombin-stimulated human platelets express molecular forms of α-granular factor V (FV), which differ from FVa. Thromb Haemost 1994; 72: 947-56.