Effect of omeprazole on the hydroxylation of warfarin enantiomers in human: In-vitro studies with liver microsomes and cDNA-expressed cytochrome P450 isozymes

Current Drug Metabolism

Volumn 6, Issue 5, 2005, Pages 399-411

  Zhou, Qingyu ^a   Zhou, Shufeng ^a   Chan, Eli ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cytochrome P450s; Drug interactions; Human liver microsomes; Omeprazole; Warfarin

Indexed keywords

4' HYDROXYWARFARIN; 6 HYDROXYWARFARIN; 7 HYDROXYWARFARIN; COMPLEMENTARY DNA; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; OMEPRAZOLE; PHENOL DERIVATIVE; UNCLASSIFIED DRUG; WARFARIN;

CONTROLLED STUDY; DOSE RESPONSE; DRUG HYDROXYLATION; DRUG INHIBITION; DRUG MECHANISM; ENANTIOMER; ENZYME ACTIVITY; HUMAN; IN VITRO STUDY; LIVER MICROSOME; PROTEIN EXPRESSION; REVIEW;

ALGORITHMS; ANTI-ULCER AGENTS; ANTICOAGULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; HUMANS; HYDROXYLATION; ISOENZYMES; MICROSOMES, LIVER; OMEPRAZOLE; STEREOISOMERISM; WARFARIN;

EID: 24944448780     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920005774330620     Document Type: Review

References (52)

1. Hirsh, J.; Dalen, J. E.; Anderson, D. R.; Poller, L.; Bussey, H.; Ansell, J.; Deykin, D. and Brandt, J. T. (1998) Chest 114(5 Suppl), S445-469.
2. Porter, R. S.; Sawyer, W. T. and Lowenthal, D. T. (1986) In Applied pharmacokinetics: Principles of therapeutic drug monitoring, (Evans, W. E., Schentag, J. J., Jusko, W. J., and Harrison, H., Eds.), Spokane: Applied Therapeutics Inc., pp. 1057-1104.
3. Breckenridge, A.; Orme, M.; Wesseling, H.; Lewis, R. J. and Gibbons, R. (1974) Clin. Pharmacol. Ther. 15(4), 424-430.
4. Hermans, J. J. and Thijssen, H. H. (1989) Biochem. Pharmacol. 38(19), 3365-3370.
5. Kaminsky, L. S.; de Morais, S. M. F.; Faletto, M. B.; Dunbar, D. A. and Goldstein, J. A. (1993) Mol. Pharmacol. 43(2), 234-239.
6. Rettie, A. E.; Korzekwa, K. R.; Kunze, K. L.; Lawrence, R. F.; Eddy, A. C.; Aoyama, T.; Gelboin, H. V.; Gonzalez, F. J. and Trager, W. F. (1992) Chem. Res. Toxicol. 5(1), 54-59.
7. Rettie, A. E.; Eddy, A. C.; Heimark, L. D.; Gibaldi, M. and Trager, W. F. (1989) Drug Metab. Dispos. 17(3), 265-270.
8. Zhang, Z.; Fasco, M. J.; Huang, Z.; Guengerich, F. P. and Kaminsky, L. S. (1995) Drug Metab. Dispos. 23(12), 1339-1346.
9. Harder, S. and Thurmann, P. (1996) Clin. Pharmacokinet. 30(6), 416-444.
10. Wells, P. S.; Holbrook, A. M.; Crowther, N. R. and Hirsh, J. (1994) Ann. Intern. Med. 121(9), 676-683.
11. Fellenius, E.; Berglindh, T.; Sachs, G.; Olbe, L.; Elander, B.; Sjöstrand, S. E. and Wallmark, B. (1981) Nature 290(5802), 159-161.
12. Regårdh, C. G.; Gabrielsson, M.; Hoffman, K. J.; Lofberg, I. and Skanberg, I. (1985) Scand. J. Gastroenterol. Suppl. 108, 79-94.
13. Clissold, S. P. and Campoli-Richards, D. M. (1986) Drugs 32(1), 15-47.
14. Andersson, T.; Miners, J. O.; Veronese, M. E. and Birkett, D. J. (1994) Br. J. Clin. Pharmacol. 37(6), 597-604.
15. Chiba, K.; Kobayashi, K.; Manabe, K.; Tani, M.; Kamataki, T. and Ishizaki, T. (1993) J. Pharmacol. Exp. Ther. 266(1), 52-59.
16. Karam, W. G.; Goldstein, J. A.; Lasker, J. M. and Ghanayem, B. I. (1996) Drug Metab. Dispos. 24(10), 1081-1087.
17. Andersson, T.; Regårdh, C. G.; Dahl-Puustinen, M. L. and Bertilsson, L. (1990) Ther. Drug Monit. 12(4), 415-416.
18. Furuta, T.; Ohashi, K.; Kosuge, K.; Zhao, X. J.; Takashima, M.; Kimura, M.; Nishimoto, M.; Hanai, H.; Kaneko, E. and Ishizaki, T. (1999) Clin. Pharmacol. Ther. 65(5), 552-561.
19. Sagar, M.; Bertilsson, L.; Stridsberg, M.; Kjellin, A.; Mardh, S. and Seensalu, R. (2000) Aliment. Pharmacol. Ther. 14(11), 1495-1502.
20. Sapone, A.; Vaira, D.; Trespidi, S.; Perna, F.; Gatta, L.; Tampieri, A.; Ricci, C.; Cantelli-Forti, G.; Miglioli, M.; Biagi, G. L. and Paolini, M. (2003) Am. J. Gastroenterol. 98(5), 1010-1015.
21. Furuta, T.; Shirai, N.; Sugimoto, M.; Ohashi, K. and Ishizaki, T. (2004) Pharmacogenomics 5(2), 181-202.
22. Funck-Brentano, C.; Becquemont, L.; Lenevu, A.; Roux, A.; Jaillon, P. and Beaune, P. (1997) J. Pharmacol. Exp. Ther. 280(2), 730-738.
23. Gugler, R. and Jensen, J. C. (1985) Gastroenterology 89(6), 1235-1241.
24. Ko, J. W.; Sukhova, N.; Thacker, D.; Chen, P. and Flockhart, D. A. (1997) Drug Metab. Dispos. 25(7), 853-862.
25. Sutfin, T.; Balmer, K.; Bostrom, H.; Eriksson, S.; Hoglund, P. and Paulsen, O. (1989) Ther. Drug Monit. 11(2), 176-184.
26. Unge, P.; Svedberg, L. E.; Nordgren, A.; Blom, H.; Andersson, T.; Lagerstrom, P. O. and Idstrom, J. P. (1992) Br. J. Clin. Pharmacol. 34(6), 509-512.
27. Hermans, J. J. and Thijssen, H. H. (1993) Br. J. Pharmacol. 110(1), 482-490.
28. West, B. D.; Preis, S.; Schroeder, C. H. and Link, K. P. (1961) J. Am. Chem. Soc. 83, 2676-2679.
29. Hermodson, M. A.; Barker, W. M. and Link, K. P. (1971) J. Med. Chem. 14(2), 167-169.
30. Trager, W. F.; Lewis, R. J. and Garland, W. A. (1970) J. Med. Chem. 13(6), 1196-1204.
31. Segel, I. H. (1975) Enzyme kinetics: behavior and analysis of rapid equilibrium and steady-state enzyme system, John Wiley & Sons, New York.
32. Ito, K.; Iwatsubo, T.; Kanamitsu, S.; Ueda, K.; Suzuki, H. and Sugiyama, Y. (1998) Pharmacol. Rev. 50(3), 387-411.
33. Breckenridge, A. and Orme, M. (1973) Clin. Pharmacol. Ther. 14(6), 955-961.
34. Black, D. J.; Kunze, K. L.; Wienkers, L. C.; Gidal, B. E.; Seaton, T. L.; McDonnell, N. D.; Evans, J. S.; Bauwens, J. E. and Trager, W. F. (1996) Drug Metab. Dispos. 24(4), 422-428.
35. Obach, R. S.; Baxter, J. G.; Liston, T. E.; Silber, B. M.; Jones, B. C.; Macintyre, F.; Rance, D. J. and Wastall, P. (1997) J. Pharmacol. Exp. Ther. 283(1), 46-58.
36. Regårdh, C.G. (1986) Scand. J. Gastroenterol. Suppl 118, 99-104.
37. Ito, K.; Brown, H.S.; Houston, J.B. (2004) Br. J. Clin. Pharmacol. 57(4), 473-486.
38. Kaminsky, L. S.; Dunbar, D. A.; Wang, P. P.; Beaune, P.; Larrey, D.; Guengerich, F. P.; Schnellmann, R. G. and Sipes, I. G. (1984) Drug Metab. Dispos. 12(4), 470-477.
39. Dickins, M. and Bridges, J. W. (1982) Biochem. Pharmacol. 31(7), 1315-1320.
40. Testa, B. and Jenner, P. (1981) Drug Metab. Rev. 12, 1-117.
41. Trager, W. F. (1989) Drug Metab. Rev. 20(2-4), 489-496.
42. Rettie, A. E.; Wienkers, L. C.; Gonzalez, F. J.; Trager, W. F. and Korzekwa, K. R. (1994) Pharmacogenetics 4(1), 39-42.
43. Sullivan-Klose, T. H.; Ghanayem, B. I.; Bell, D. A.; Zhang, Z. Y.; Kaminsky, L. S.; Shenfield, G. M.; Miners, J. O.; Birkett, D. J. and Goldstein, J. A. (1996) Pharmacogenetics 6(4), 341-349.
44. Haining, R. L.; Hunter, A. P.; Veronese, M. E.; Trager, W. F. and Rettie, A. E. (1996) Arch. Biochem. Biophys. 333(2), 447-458.
45. Steward, D. J.; Haining, R. L.; Henne, K. R.; Davis, G.; Rushmore, T. H.; Trager, W. F. and Rettie, A. E. (1997) Pharmacogenetics 7(5), 361-367.
46. Scordo, M. G.; Aklillu, E.; Yasar, U.; Dahl, M. L.; Spina, E. and Ingelman-Sundberg, M. (2001) Br. J. Clin. Pharmacol. 52(4), 447-450.
47. Andersson, T.; Cederberg, C.; Edvardsson, G.; Heggelund, A. and Lundborg, P. (1990) Clin. Pharmacol. Ther. 47(1), 79-85.
48. Gustavson, L. E.; Kaiser, J. F.; Edmonds, A. L.; Locke, C. S.; De-Bartolo, M. L. and Schneck, D. W. (1995) Antimicrob. Agents Chemother. 39(9), 2078-2083.
49. Calabresi, L.; Pazzucconi, F.; Ferrara, S.; Di Paolo, A.; Tacca, M. D. and Sirtori, C. (2004) Pharmacol. Res. 49(5), 493-499.
50. Andersson, T.; Holmberg, J.; Rohss, K. and Walan, A. (1998) Br. J. Clin. Pharmacol. 45(4), 369-375.
51. Oosterhuis, B.; Jonkman, J. H.; Andersson, T. and Zuiderwijk, P. B. (1992) J. Clin. Pharmacol. 32(5), 470-475.
52. Bourrie, M.; Meunier, V.; Berger, Y. and Fabre, G. (1996) J. Pharmacol. Exp. Ther. 277(1), 321-332.