Experimental study of serum substantia nigra neuron autoantibody and its effect in parkinson disease patients

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 21, Issue 4, 2001, Pages 280-282

  Chen, Jixiang ^a   Cao, Xuebing ^a   Xu, Yan ^a   Sun, Shenggang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Autoantibody; Parkinson disease; Serum; Substantia nigra

Indexed keywords

DISEASES; IMMUNOLOGY; MATHEMATICAL MODELS; NEUROLOGY; PATIENT TREATMENT;

AUTOANTIBODY; PARKINSON DISEASE (PD); SERUM; SUBSTANTIA NIGRA;

ANTIBODIES;

AUTOANTIBODY;

ADULT; AGED; ANIMAL; ARTICLE; BLOOD; FEMALE; HUMAN; IMMUNOLOGY; MALE; MICROINJECTION; MIDDLE AGED; PARKINSON DISEASE; RAT; SPRAGUE DAWLEY RAT; SUBSTANTIA NIGRA;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; AUTOANTIBODIES; FEMALE; HUMANS; MALE; MICROINJECTIONS; MIDDLE AGED; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA;

EID: 24744468056     PISSN: 0257716X     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02886556     Document Type: Review

References (9)

1. Naoi M, Maruyama W. Cell death of dopamine neurons in aging and Parkinson's disease. Mech Ageing Dev, 1999, 111 (2-3):175
2. McRae-Degueurce A, Rosengren L, Haglid K et al. Immunocytochemical investigations on the presence of neuron- specific antibodies in the CSF of Parkinson's disease cases. Neurochem Res, 1988, 13(7):679
3. Hao R, Norgren R B, Jr Lau R S et al. Cerebrospinal fluid of Parkinson's disease patients inhibits the growth and function of dopaminergic neruons in culture. Neurology, 1995, 45(1):138
4. Chen S, Le W D, Xie W J et al. Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins. Arch Neurol, 1998, 55(8):1075
5. Engelhardt J I, Le W D, Siklos L et al. Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain. Arch Neurol, 2000, 57(6):681
6. Herrera A J, Castano A, Venero J L et al. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. Neurobiol Dis, 2000, 7(4):429
7. Czlonkowska A, Kurkowska-Jastrzebska I, Czlonkowski A. Inflammatory changes in the substantia nigra and striatum following MPTP intoxication. Ann Neurol, 2000,48(1):127
8. Ulvestad E, Williams K, Vedeler C et al. Fc receptors for IgG on cultured human microglia mediate cytotoxicity and phagocytosis of antibody-coated targets. J Neuropathol Exp Neurol, 1994, 53(1):27
9. Kreutzberg G W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci, 1996, 19(8):312