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Volumn 7, Issue H, 2005, Pages

Heart rate slowing by If inhibition: Therapeutic utility from clinical trials

Author keywords

Angina pectoris; Cardiovascular pharmacology; Coronary artery disease

Indexed keywords

AMLODIPINE; ANTIANGINA PECTORIS AGENT; ANTIARRHYTHMIC AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIGITALIS; IVABRADINE; MONOAMINE OXIDASE INHIBITOR; NITRIC ACID DERIVATIVE; ZATEBRADINE;

EID: 24744461912     PISSN: 1520765X     EISSN: None     Source Type: Journal    
DOI: 10.1093/eurheartj/sui050     Document Type: Article
Times cited : (10)

References (47)
  • 1
    • 0031053265 scopus 로고    scopus 로고
    • Management of stable angina pectoris. Recommendations of the Task Force of the European Society of Cardiology
    • Management of stable angina pectoris. Recommendations of the Task Force of the European Society of Cardiology. Eur Heart J 1997;18:394-413.
    • (1997) Eur Heart J , vol.18 , pp. 394-413
  • 2
    • 0033152353 scopus 로고    scopus 로고
    • ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: Executive summary and recommendations
    • Gibbons RJ, Chatterjee K, Daley J et al. ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: executive summary and recommendations. Circulation 1999;99:2829-2848.
    • (1999) Circulation , vol.99 , pp. 2829-2848
    • Gibbons, R.J.1    Chatterjee, K.2    Daley, J.3
  • 3
    • 0035797884 scopus 로고    scopus 로고
    • Guidelines for the management of patients with chronic stable angina: Diagnosis and risk stratification
    • Williams SV, Fihn SD, Gibbons RJ. Guidelines for the management of patients with chronic stable angina: diagnosis and risk stratification. Ann Int. Med 2001;135:530-547.
    • (2001) Ann Int. Med , vol.135 , pp. 530-547
    • Williams, S.V.1    Fihn, S.D.2    Gibbons, R.J.3
  • 4
    • 0037305154 scopus 로고    scopus 로고
    • Contributions of heart rate and contractility to myocardial oxygen balance during exercise
    • Colin P, Ghaleh B, Monnet X, et al. Contributions of heart rate and contractility to myocardial oxygen balance during exercise. Am J Physiol Heart Circ Physiol 2003;284:H676-H682.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284
    • Colin, P.1    Ghaleh, B.2    Monnet, X.3
  • 5
    • 0345866810 scopus 로고    scopus 로고
    • Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs
    • Colin P, Ghaleh B, Monnet X et al. Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs. J Pharmacol Exp Ther 2004;308:236-240.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 236-240
    • Colin, P.1    Ghaleh, B.2    Monnet, X.3
  • 6
    • 0035949564 scopus 로고    scopus 로고
    • Left ventricular muscle mass and elevated heart-rate are associated with coronary plaque disruption
    • Heidland UE, Strauer BE. Left ventricular muscle mass and elevated heart-rate are associated with coronary plaque disruption. Circulation 2001;104:1477-1482.
    • (2001) Circulation , vol.104 , pp. 1477-1482
    • Heidland, U.E.1    Strauer, B.E.2
  • 7
    • 0002777814 scopus 로고    scopus 로고
    • Is heart rate a risk factor in the general population?
    • Habib G. Is heart rate a risk factor in the general population? Dialogues Cardiovasc Med 2001;6:25-31.
    • (2001) Dialogues Cardiovasc Med , vol.6 , pp. 25-31
    • Habib, G.1
  • 8
    • 0029869881 scopus 로고    scopus 로고
    • Factors associated with survival to 75 years of age in middle-aged men and women: The Framingham Study
    • Goldberg R, Larson M, Levy D. Factors associated with survival to 75 years of age in middle-aged men and women: The Framingham Study. Arch Intern Med 1996;156:505-509.
    • (1996) Arch Intern Med , vol.156 , pp. 505-509
    • Goldberg, R.1    Larson, M.2    Levy, D.3
  • 9
    • 0023765478 scopus 로고
    • The epidemiology of resting heart rate in a national sample of men and women: Association with hypertension, coronary artery disease, blood pressure, and other cardiovascular risk factors
    • Gillum R. The epidemiology of resting heart rate in a national sample of men and women: association with hypertension, coronary artery disease, blood pressure, and other cardiovascular risk factors. Am Heart J 1988;116:163-174.
    • (1988) Am Heart J , vol.116 , pp. 163-174
    • Gillum, R.1
  • 10
    • 20444505470 scopus 로고    scopus 로고
    • Impact of heart rate on cardiovascular disorders: Focus on chronic stable angina
    • Fox K, ed. London: Science Press Ltd
    • f Channel Inhibition in Cardiology. London: Science Press Ltd; 2004. p25-36.
    • (2004) f Channel Inhibition in Cardiology , pp. 25-36
    • Singh, B.N.1
  • 12
    • 0242311040 scopus 로고    scopus 로고
    • Calcium channel blockers
    • Frishman WH, Sonnenblick EH, Sica DA, eds. New York: McGraw-Hill
    • Frishman WH, Sica DA. Calcium channel blockers. In: Frishman WH, Sonnenblick EH, Sica DA, eds. Cardiovascular Pharmacotherapies. 2nd ed. New York: McGraw-Hill; 2003. p105-130.
    • (2003) Cardiovascular Pharmacotherapies. 2nd Ed. , pp. 105-130
    • Frishman, W.H.1    Sica, D.A.2
  • 13
    • 0014510166 scopus 로고
    • Treatment of angina pectoris by electrical stimulation of the carotid sinus nerves
    • Epstein SE, Beiser GD, Goldstein RE et al. Treatment of angina pectoris by electrical stimulation of the carotid sinus nerves. N Eng J Med 1969;280:971-978.
    • (1969) N Eng J Med , vol.280 , pp. 971-978
    • Epstein, S.E.1    Beiser, G.D.2    Goldstein, R.E.3
  • 14
    • 9244236566 scopus 로고    scopus 로고
    • Total Ischaemic Burden European Trial (TIBET). Effects of ischaemia and treatment with atenolol, nifedipine SR and their combination on outcome in patients with chronic stable angina the TIBET study group
    • Dargie HJ, Ford I, Fox K et al. Total Ischaemic Burden European Trial (TIBET). Effects of ischaemia and treatment with atenolol, nifedipine SR and their combination on outcome in patients with chronic stable angina The TIBET study group. Eur Heart J 1997;17:104-112.
    • (1997) Eur Heart J , vol.17 , pp. 104-112
    • Dargie, H.J.1    Ford, I.2    Fox, K.3
  • 15
    • 0018387132 scopus 로고
    • How does adrenaline accelerate the heart?
    • Brown HF, DiFrancesco D, Noble SJ. How does adrenaline accelerate the heart? Nature 1979;280:235-236.
    • (1979) Nature , vol.280 , pp. 235-236
    • Brown, H.F.1    DiFrancesco, D.2    Noble, S.J.3
  • 16
    • 0023795120 scopus 로고
    • f) induced by acetylcholine in rabbit sino-atrial node myocytes
    • f) induced by acetylcholine in rabbit sino-atrial node myocytes. J Physiol (Lond) 1988;405:477-491.
    • (1988) J Physiol (Lond) , vol.405 , pp. 477-491
    • DiFrancesco, D.1    Tromba, C.2
  • 17
    • 0025977991 scopus 로고
    • f) to generation of spontaneous activity in rabbit sino-atrial node myocytes
    • f) to generation of spontaneous activity in rabbit sino-atrial node myocytes. J Physiol 1991;434:23-40.
    • (1991) J Physiol , vol.434 , pp. 23-40
    • DiFrancesco, D.1
  • 18
    • 10644258954 scopus 로고    scopus 로고
    • Development of cardiovascular drugs: The U.S. regulatory milieu from the perspective of a participating non-regulator
    • Borer JS. Development of cardiovascular drugs: the U.S. regulatory milieu from the perspective of a participating non-regulator. J Am Coll Cardiol 2004;44:2285-2292.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 2285-2292
    • Borer, J.S.1
  • 19
    • 0027496931 scopus 로고
    • f in rabbit sinoatrial node cells by zatebradine (UL-FS 49). on the mode of action of sinus node inhibitors
    • f in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors. Circulation 1993;88:2389-2401.
    • (1993) Circulation , vol.88 , pp. 2389-2401
    • Goethals, M.1    Raes, A.2    Van Bogaert, P.P.3
  • 20
    • 0029147595 scopus 로고
    • Addition of zatebradine, a direct sinus node inhibitor, provides no greater exercise tolerance benefit in patients with angina taking extended-release nifedipine: Results of a multicenter, randomised, double-blind, placebo-controlled, parallel-group study
    • Frishman WH, Pepine CJ, Weiss RJ et al. Addition of zatebradine, a direct sinus node inhibitor, provides no greater exercise tolerance benefit in patients with angina taking extended-release nifedipine: results of a multicenter, randomised, double-blind, placebo-controlled, parallel-group study. J Am Coll Cardiol 1995;26:305-312.
    • (1995) J Am Coll Cardiol , vol.26 , pp. 305-312
    • Frishman, W.H.1    Pepine, C.J.2    Weiss, R.J.3
  • 21
    • 14044265257 scopus 로고    scopus 로고
    • Innovative pharmacologic approaches to treatment of myocardial ischemia
    • Frishman WH, Sonnenblick EH, Sica DA, eds. New York: McGraw-Hill
    • Frishman WH, Retter A, Misailidis J et al. Innovative pharmacologic approaches to treatment of myocardial ischemia. In: Frishman WH, Sonnenblick EH, Sica DA, eds. Cardiovascular Pharmacotherapies. 2nd ed. New York: McGraw-Hill; 2003. p655-690.
    • (2003) Cardiovascular Pharmacotherapies. 2nd Ed. , pp. 655-690
    • Frishman, W.H.1    Retter, A.2    Misailidis, J.3
  • 22
    • 0028358379 scopus 로고
    • Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea pig-cardiac preparations: Comparison with UL-FS 49
    • Thollon C, Cambarrat C, Vian J et al. Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea pig-cardiac preparations: comparison with UL-FS 49. Br J Pharmacol 1994;112:37-42.
    • (1994) Br J Pharmacol , vol.112 , pp. 37-42
    • Thollon, C.1    Cambarrat, C.2    Vian, J.3
  • 23
    • 0029582832 scopus 로고
    • Coronary and haemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs
    • Simon L, Ghaleh B, Puybasset L et al. Coronary and haemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs. J Pharm Exp Ther 1995;275:659-666.
    • (1995) J Pharm Exp Ther , vol.275 , pp. 659-666
    • Simon, L.1    Ghaleh, B.2    Puybasset, L.3
  • 24
    • 0036089596 scopus 로고    scopus 로고
    • Differential effects of heart rate reduction and beta-blockade on left ventricular relaxation during exercise
    • Colin P, Ghaleh B, Hittinger L et al. Differential effects of heart rate reduction and beta-blockade on left ventricular relaxation during exercise. Am J Physiol Heart Circ Physiol 2002;282:H672-H679.
    • (2002) Am J Physiol Heart Circ Physiol , vol.282
    • Colin, P.1    Ghaleh, B.2    Hittinger, L.3
  • 25
    • 20444496743 scopus 로고    scopus 로고
    • Effects of a pure bradycardic agent, S 16257, at rest and during exercise in healthy volunteers: Comparison with propranolol
    • Moore N, Joannides R, Iacob M et al. Effects of a pure bradycardic agent, S 16257, at rest and during exercise in healthy volunteers: comparison with propranolol. Br J Clin Pharm 1998;45:188-189.
    • (1998) Br J Clin Pharm , vol.45 , pp. 188-189
    • Moore, N.1    Joannides, R.2    Iacob, M.3
  • 26
    • 0344394916 scopus 로고    scopus 로고
    • A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction
    • Manz M, Reuter M, Lauck G et al. A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction. Cardiology 2003;100:149-155.
    • (2003) Cardiology , vol.100 , pp. 149-155
    • Manz, M.1    Reuter, M.2    Lauck, G.3
  • 27
    • 0035192922 scopus 로고    scopus 로고
    • Effect of heart rate reduction with ivabradine on exercise induced myocardial ischaemia and stunning
    • Monnet X, Ghaleb B, Colin P et al. Effect of heart rate reduction with ivabradine on exercise induced myocardial ischaemia and stunning. J Pharm Exp Ther 2001;299:1133-1139.
    • (2001) J Pharm Exp Ther , vol.299 , pp. 1133-1139
    • Monnet, X.1    Ghaleb, B.2    Colin, P.3
  • 28
    • 4544344025 scopus 로고    scopus 로고
    • f current inhibition with ivabradine: A new therapeutic perspective in cardiovascular disease
    • f current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs 2004;64:1757-1765.
    • (2004) Drugs , vol.64 , pp. 1757-1765
    • DiFrancesco, D.1    Camm, J.2
  • 29
    • 0031578576 scopus 로고    scopus 로고
    • Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S 16257
    • Thollon C, Bidouard JP, Cambarrat C et al. Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S 16257. Eur J Pharmacol 1997;339:43-51.
    • (1997) Eur J Pharmacol , vol.339 , pp. 43-51
    • Thollon, C.1    Bidouard, J.P.2    Cambarrat, C.3
  • 30
    • 20444457018 scopus 로고    scopus 로고
    • f inhibitors as specific heart rate reducing agents
    • f inhibitors as specific heart rate reducing agents. Nature (Clin Pract Cardiovasc) 2004;1:103-109.
    • (2004) Nature (Clin Pract Cardiovasc) , vol.1 , pp. 103-109
    • Borer, J.S.1
  • 31
    • 0346020348 scopus 로고    scopus 로고
    • Natural history endpoints and angina trials
    • Borer JS, Somberg JC, eds. New York: Marcel Dekker
    • Lipicky RJ. Natural history endpoints and angina trials. In: Borer JS, Somberg JC, eds. Cardiovascular Drug Development: Protocol Design and Methodology. New York: Marcel Dekker; 1999. p185-187.
    • (1999) Cardiovascular Drug Development: Protocol Design and Methodology , pp. 185-187
    • Lipicky, R.J.1
  • 32
    • 0037448788 scopus 로고    scopus 로고
    • f inhibitor, in stable angina: A randomized, double-blinded, multi-centered, placebo-controlled trial
    • f inhibitor, in stable angina: a randomized, double-blinded, multi-centered, placebo-controlled trial. Circulation 2003;107:817-823.
    • (2003) Circulation , vol.107 , pp. 817-823
    • Borer, J.S.1    Fox, K.2    Jaillon, P.3
  • 33
    • 0345637900 scopus 로고    scopus 로고
    • f current inhibitor ivabradine compared to atenolol as monotherapies in patients with chronic stable angina. A 4-month randomised, double-blinded, multicenter, controlled non-inferiority trial
    • f current inhibitor ivabradine compared to atenolol as monotherapies in patients with chronic stable angina. A 4-month randomised, double-blinded, multicenter, controlled non-inferiority trial. Eur Heart J 2003;24(Suppl.):20.
    • (2003) Eur Heart J , vol.24 , Issue.SUPPL. , pp. 20
    • Tardif, J.C.1    Ford, I.2    Tendera, M.3
  • 34
    • 24744465984 scopus 로고    scopus 로고
    • Anti-anginal and anti-ischaemic effects of the if current inhibitor ivabradine compared to amlodipine as monotherapies in patients with chronic stable angina. Randomised, controlled, double-blind trial
    • Ruzyllo W, Ford IF, Tendera MT, et al. on behalf of the study investigators. Anti-anginal and anti-ischaemic effects of the If current inhibitor ivabradine compared to amlodipine as monotherapies in patients with chronic stable angina. Randomised, controlled, double-blind trial. Eur Heart J 2004;25(Suppl.):138.
    • (2004) Eur Heart J , vol.25 , Issue.SUPPL. , pp. 138
    • Ruzyllo, W.1    Ford, I.F.2    Tendera, M.T.3
  • 35
    • 24744458304 scopus 로고    scopus 로고
    • f current inhibitor ivabradine in patients with chronic stable angina. A one year randomised, double-blind, multicentre trial
    • f current inhibitor ivabradine in patients with chronic stable angina. A one year randomised, double-blind, multicentre trial. Eur Heart J 2004;25(Suppl.):138.
    • (2004) Eur Heart J , vol.25 , Issue.SUPPL. , pp. 138
    • Lopez-Bescos, L.1    Filipova, S.2    Martos, R.3
  • 36
    • 0028025629 scopus 로고
    • Characteristics of a contemporary population with angina pectoris: TIDES Investigators
    • Pepine CJ, Abrams J, Marks RG et al. Characteristics of a contemporary population with angina pectoris: TIDES Investigators. Am J Cardiol 1994;74:226-231.
    • (1994) Am J Cardiol , vol.74 , pp. 226-231
    • Pepine, C.J.1    Abrams, J.2    Marks, R.G.3
  • 37
    • 0027384218 scopus 로고
    • Adverse reactions with beta-adrenoceptor blocking drugs: An update
    • Lewis RV, Lofthouse C. Adverse reactions with beta-adrenoceptor blocking drugs: an update. Drug Safety 1993;9:272-279.
    • (1993) Drug Safety , vol.9 , pp. 272-279
    • Lewis, R.V.1    Lofthouse, C.2
  • 38
    • 0025648690 scopus 로고
    • Respiratory function in the elderly and the effects of beta blockade
    • Tattersfield AE. Respiratory function in the elderly and the effects of beta blockade. Cardiovasc Drugs Ther 1991;4(Suppl. 6):1229-1232.
    • (1991) Cardiovasc Drugs Ther , vol.4 , Issue.6 SUPPL. , pp. 1229-1232
    • Tattersfield, A.E.1
  • 39
    • 0034669099 scopus 로고    scopus 로고
    • Beta blocker therapy for chronic heart failure
    • Ramahi TM. Beta blocker therapy for chronic heart failure. Am Fam Physician 2000;62:2267-2274.
    • (2000) Am Fam Physician , vol.62 , pp. 2267-2274
    • Ramahi, T.M.1
  • 40
    • 0034097806 scopus 로고    scopus 로고
    • Induction of insulin resistance by beta-blockade but not ACE-inhibition: Long-term treatment with atenolol or trandolapril
    • Reneland R, Alvarez E, Andersson PE et al. Induction of insulin resistance by beta-blockade but not ACE-inhibition: long-term treatment with atenolol or trandolapril. J Hum Hypertens 2000;14:175-180.
    • (2000) J Hum Hypertens , vol.14 , pp. 175-180
    • Reneland, R.1    Alvarez, E.2    Andersson, P.E.3
  • 41
    • 0024202991 scopus 로고
    • Effects of antihypertensives on plasma lipids and lipoprotein metabolism
    • Krone W, Nagele H. Effects of antihypertensives on plasma lipids and lipoprotein metabolism. Am Heart J 1988;116:1729-1734.
    • (1988) Am Heart J , vol.116 , pp. 1729-1734
    • Krone, W.1    Nagele, H.2
  • 42
    • 20444474400 scopus 로고    scopus 로고
    • The organic nitrates and nitroprusside
    • Frishman WH, Sonnenblick EH, Sica DA, eds. New York: McGraw-Hill
    • Abrams J, Frishman WH. The organic nitrates and nitroprusside. In: Frishman WH, Sonnenblick EH, Sica DA, eds. Cardiovascular Pharmacotherapies. New York: McGraw-Hill; 2003. p203-214.
    • (2003) Cardiovascular Pharmacotherapies , pp. 203-214
    • Abrams, J.1    Frishman, W.H.2
  • 43
    • 0023883740 scopus 로고
    • Transient myocardial ischemia after abrupt withdrawal of antianginal therapy in chronic stable angina
    • Egstrup K. Transient myocardial ischemia after abrupt withdrawal of antianginal therapy in chronic stable angina. Am J Cardiol 1988;61:1219-1222.
    • (1988) Am J Cardiol , vol.61 , pp. 1219-1222
    • Egstrup, K.1
  • 44
    • 0025748846 scopus 로고
    • Acute and chronic antianginal efficacy in continuous twenty-four hour application of transdermal nitroglycerin
    • Steering Committee, Transdermal Nitroglycerin Cooperative Study. Acute and chronic antianginal efficacy in continuous twenty-four hour application of transdermal nitroglycerin. Am J Cardiol 1991;68:1263-1270.
    • (1991) Am J Cardiol , vol.68 , pp. 1263-1270
  • 45
    • 0030874897 scopus 로고    scopus 로고
    • Rest heart rate and life expectancy
    • Levine HJ. Rest heart rate and life expectancy. J Am Coll Cardiol 1997;30:1104-1106.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 1104-1106
    • Levine, H.J.1
  • 46
    • 0033011678 scopus 로고    scopus 로고
    • Heart rate as a therapeutic target in heart failure
    • Kjekshus J, Gullestad L. Heart rate as a therapeutic target in heart failure. Eur Heart J 1999;1(Suppl. H):H64-H69.
    • (1999) Eur Heart J , vol.1 , Issue.SUPPL. H
    • Kjekshus, J.1    Gullestad, L.2
  • 47
    • 0022541191 scopus 로고
    • Importance of heart rate in determining beta-blocker efficacy in acute and long-term myocardial intervention trials
    • Kjekshus JK. Importance of heart rate in determining beta-blocker efficacy in acute and long-term myocardial intervention trials. Am J Cardiol 1986;57:43F-49F.
    • (1986) Am J Cardiol , vol.57
    • Kjekshus, J.K.1


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