A simple bioassay for evaluating immunotoxic properties of chemicals by use of in vitro antibody production system

Journal of Health Science

Volumn 48, Issue 2, 2002, Pages 161-167

  Takahashi, Kazuko ^a   Ohsawa, Motoyasu ^a   Utsumi, Hideo ^b  

^a TEIKYO UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Immunotoxicity; In vitro IgM production; Mouse spleen cell; Pokeweed mitogen

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DIETHYLSTILBESTROL; DIMETHYL SULFOXIDE; ESTRADIOL; ETHINYLESTRADIOL; IMMUNOGLOBULIN M ANTIBODY; LEAD NITRATE; MITOCHONDRIAL ENZYME; POKEWEED MITOGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ARTICLE; BIOASSAY; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTOXICITY; MALE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; REFERENCE VALUE; SPLEEN CELL;

ANIMALIA; PHYTOLACCACEAE;

EID: 24744440566     PISSN: 13449702     EISSN: None     Source Type: Journal    
DOI: 10.1248/jhs.48.161     Document Type: Article

References (13)

1. WHO Task Group (1996) Principles and Methods for Assessing Direct Immunotoxicity Associated with Exposure to Chemicals. WHO, Geneva.
2. Ohsawa, M. (1993) Nutritional and toxicological implication of trace elements in the immune response. In Essential and Trace Elements in Human Health and Disease: An Update (Prasad, A. S., Ed.), Wiley-Liss, Inc., New York, pp. 283-298.
3. Luster, M. I., Selgrade, M. K., Germolec, D. R., Burleson, F. G., Kayama, F., Comment, C. E. and Wilmer, J. L. (1994) Experimental studies on immunosuppression. In Immunotoxicology and Immunopharmacology (Dean, J. H. et al., Eds.), Raven Press, New York, pp. 51-69.
4. Ashman, R. F. (1984) Lymphocyte activation. In Fundamental Immunology (Paul, W. E., Ed.), Raven Press, New York, pp. 267-300.
5. Martinez, F. and Coleman, J. W. (1989) The effects of selected drugs, including chloropromazine and non-steroidal anti-inflammatory agents, on polyclonal IgG synthesis and interleukin 1 production by human peripheral blood mononuclear cells in vitro. Clin. Exp. Immunol., 76, 252-257.
6. Martinez, F. and Coleman, J. W. (1992) Immunoglobulin production by B cells: In vitro toxicology. In In Vitro Methods of Toxicology (Watson, R. R., Ed.), CRC Press, Boca Raton, pp. 21-35.
7. Ohsawa, M., Masuko-Sato, K., Takahashi, K. and Otsuka, F. (1986) Strain differences in cadmium-mediated suppression of lymphocyte proliferation in mice. Toxicol. Appl. Pharmacol., 84, 379-388.
8. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
9. Goldham, N. G., Dave, M., Sivapathasundaram, S., McDonnell, D. P., Connor, C. and Sauer, M. J. (1997) Evaluation of a recombinant yeast cell estrogen screening assay. Environ. Health Perspect., 105, 734-742.
10. Harris, C. A., Henttu, P., Parker, M. G. and Sumpter, J. P. (1997) The estrogenic activity of phthalate esters in vitro. Environ. Health Perspect., 105, 802-811.
11. Borella, P. and Giardino, A. (1991) Lead and cadmium at very low doses affect in vitro immune response of human lymphocytes. Environ. Res., 55, 165-177.
12. Clarke, A. G. and Kendall, M. D. (1994) The thymus in pregnancy: the interplay of neural, endocrine and immune influences. Immunol. Today, 15, 545-574.
13. Pfeifer, R. W. and Patterson, R. M. (1986) Modulation of lectin-stimulated lymphocyte agglutination and mitogenesis by estrogen metabolites: Effects on early events of lymphocyte activation. Arch. Toxicol., 58, 157-164.