Antiulcer properties of the ethanol root extract of Cissampelos mucronata

Pharmaceutical Biology

Volumn 43, Issue 5, 2005, Pages 396-403

  Nwafor, S V ^a   Okoye, C F ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Antiulcer; Cissampelos mucronata; Root extract

Indexed keywords

ALCOHOL; ANTIULCER AGENT; CIMETIDINE; CISSAMPELOS MUCRONATA EXTRACT; HISTAMINE; INDOMETACIN; POLYSORBATE 85; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CISSAMPELOS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GUINEA PIG; ILEUM; LD 50; MEDICINAL PLANT; MOUSE; MYOMETRIUM; NONHUMAN; PLANT ROOT; RAT; RECEPTOR BLOCKING; SMOOTH MUSCLE RELAXATION; STRESS ULCER; TISSUE PREPARATION; TOXICITY TESTING; UTERUS;

CISSAMPELOS MUCRONATA; MENISPERMACEAE;

EID: 24744437964     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1080/13880200590963222     Document Type: Article

References (41)

1. Akah PA, Nwafor SV (1999): Studies on anti-ulcer properties of Cissampelos mucronata leaf extract. Indian J Exp Biol 37: 936-938.
2. Akah PA, Nwafor SV, Okoli CO, Orji UI (2001): Evaluation of anti-ulcer properties of Pseudocedrela kotschyi stem bark extract. Discov Inno 13: 132-135.
3. Akah PA, Nwafor SV, Okoli CO, Egboha CU (2002): Evaluation of the sedative properties of the ethanol root extract of Cissampelos mucronata. Boll Chim Farmac 141: 243-246.
4. Al-Harbi MM, Qureshi S, Raza M, Ahmed MM, Afzal M, Shah AH (1997): Gastric anti-ulcer and cytoprotective effect of Commiphora molmol in rats. J Ethnopharmacol 55: 141-150.
5. Anadan R, Rekha RD, Saravanan N, Devaki T (1999): Protective effects of Picrorrhiza kurroa against HCl/ethanol-induced ulceration in rats. Fitoterapia 70: 498-501.
6. Anonymous (1974): Staff of the Department of Pharmacology, University of Edinburgh. Pharmacological Experiment on Isolated Preparations. Edinburgh, E. L. S Livingston, pp. 58-79.
7. Audu JA (1995): Studies on the effectiveness of medicinal herbs used as anthelmintics by traditional medical practitioners in South of Bauchi State-II. J Econ Tax Bot 19: 653-661.
8. Austin A, Jegadeesan M (2002): Gastric and duodenal anti-ulcer and cytoprotective effects of Cissus quadrangularis L. variant in rats. Nig J Nat Prod Med 6: 10-14.
9. Banoob DW, McCloskey WW, Webster W (2002): Risk of gastric injury with enteric-coated versus nonenteric-coated aspirin. Ann Pharmacother 36: 163-166.
10. Benson L (1957): Plant Classification. USA, D. C. Health and Company, p. 131.
11. Brown NJ, Roberts LJ (2001): Histamine, bradykinin and their antagonists. In: Hardman JG, Limberb LE, eds., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed. New, York, McGraw Hill, p. 650.
12. Bruneton J (1995): Pharmacognosy, Phytochemistry, Medicinal Plants. Andover, England, Intercept Limited, p. 726.
13. Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo Z (1985): Medicinal plants in therapy. Bull WHO 63: 965-981.
14. 2-receptor antagonist-standard therapy for acid-peptic diseases. First part. N Engl J Med 323: 1672-1680.
15. 2-receptor antagonist-standard therapy for acid-peptic diseases. Second part. N Engl J Med 323: 1749-1755.
16. Gonzalez ER (1990): Pathophysiologic changes in the critically ill patient: Risk factors for ulceration and altered drug metabolism. Ann Pharmacother 24: S5-S7.
17. Gottlieb JE, Menashe PI, Cruz E (1986): Gastrointestinal complications in critically ill patients: the intensivists' overview. Am J Gastroenterol 81: 227-238.
18. Hawkey CJ, Rampton DS (1985): Prostaglandins and the gastrointestinal mucosa: Are they important in its function, disease or treatment? Gastroenterology 89: 1162-1168.
19. Hiraoka M, Yamagishi S, Sano T (1968): Role of calcium ions in the contraction of smooth muscle. Am J Physiol 214: 1084-1089.
20. Hoogerwerf WA, Pasricha PJ (2001). Agents used for control of gastric acidity and treatment of peptic ulcers and gastrooesophageal reflux disease. In: Hardman JG, Limbird LE, eds., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed. New York, McGraw-Hill, pp. 1005-10020.
21. Hutchison J, Dalziel JM (1954): Flora of West Tropical Africa. Crown Agents for Overseas Government and Administration, p. 25.
22. Jain SM, Parmar NS, Santani DD (1994): Gastric anti-ulcer activity of calcium channel blockers in rats. Indian J Pharmacol 26: 29-34.
23. Karaki H, Ozaki H, Hori M, Mitsui-Saito M, Amano K, Harada K, Miyamoto S, Nakazawa H, Won K, Sato K (1997): Calcium movements, distribution, and functions in smooth muscle. Pharmacol Rev 49: 157-230.
24. Langason RBF, Akunyili DN, Akubue PI (1994): A preliminary study of the gastrointestinal effect of some Nigerian medicinal plants. Fitoterapia 65: 235-240.
25. Lewis WH, Lewis M (1977): Medical Botany. New York, John Wiley & Sons, p. 324.
26. Lorke D (1983): A new approach to practical acute toxicity testing. Arch Toxicol 54: 275-289.
27. Main IHM, Whittle NB Jnr (1975): Investigation of vasodilator and antisecretory role of prostaglandin in the rat mucosa by use of NSAIDs. Br J Pharmacol 53: 217-224.
28. Mersereau WA, Hinchey EJ (1988): Relationship between myoelectric and mechanical activity in the genesis of ulcers in indomethacin-insulin treated rats. Dig Dis Sci 33: 200-208.
29. Northnover BJ (1977): Indomethacin, a calcium antagonist. Gen Pharmacol 8: 293-296.
30. Nwafor SV, Akah PA (2003): Effect of methanol leaf extract of Cissampelos mucronata A, Rich against indomethacin induced ulcer in rats. Indian J Exp Biol 41: 181-183.
31. Nwafor SV, Akah PA, Okoli CO, Ndu OO, Ichu EO (2002): Uterine relaxant property of the ethanol root extract of Cissampelos mucronata. J Nat Remedies 2: 59-65.
32. Nwafor SV, Akah PA, Okoli CO, Udeogranya OP, Oguagha UM (2003): Spasmolytic activity of the root extract of Cissampelos mucronata. J Herbal Pharmcother 4 (in Press).
33. Offiah VN, Akah PA, Isizoh AO (1996): Spasmolytic activity of Cissampelos mucronata leaf extract. Phytother Res 10: 322-324.
34. Ogle CW, Cho CH, Tong MC, Koo MWL (1985): The influence of verapamil on the gastric effects of stress in rats. Eur J Pharmacol 112: 399-404.
35. Oliver B (1969): Selecting local drug plant in Nigeria. Botanical and chemical relationship in three families. Quart J Crude Drug Res 7-9: 1194-1211.
36. Quitana A (1978): Effect of primozide on the responses of smooth muscle to non-dopamine agonist and calcium. Eur J Pharmacol 53: 113-116.
37. Silverstein FE, Gilbert DA, Tedesco FJ, Buenger NK, Persing J (1981): The national ASGE survey on upper gastrointestinal bleeding: I. Study design and baseline data. Gastrointest Endosc 27: 73-79.
38. Suziki Y, Hayachi M, Ito M, Yamagani T (1976): Anti-ulcer effect of cetraxate on various experimental gastric ulcer in rat. Jpn J Pharmacol 26: 471.
39. Urishidani T, Kasuya Y, Okabe S (1979): The mechanism of aggravation of indomethacin-induced ulcer by adrenalectomy in rats. Jpn J Pharmacol 29: 775-780.
40. Wightkin WT (1980): Stress ulcer: Pathophysiology and prevention. Am J Hosp Pharmacy 37: 1651-1655.
41. Wolfe MM, Lichtenstein DR, Singh G (1999): Gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. N Engl J Med 340: 1888-1899.