α-helical domain is essential for antimicrobial activity of high mobility group nucleosomal binding domain 2 (HMGN2)

Acta Pharmacologica Sinica

Volumn 26, Issue 9, 2005, Pages 1087-1092

  Feng, Yun ^a   Huang, Ning ^a   Wu, Qi ^a   Bao, Lang ^a   Wang, Bo Yao ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Antimicrobial activity; Antimicrobial domain; HMGN2

Indexed keywords

HIGH MOBILITY GROUP N2 PROTEIN; RECOMBINANT PROTEIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CANDIDA ALBICANS; CARBOXY TERMINAL SEQUENCE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG POTENCY; DRUG SENSITIVITY; ESCHERICHIA COLI; EXPRESSION VECTOR; GEL ELECTROPHORESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-INFECTIVE AGENTS; CANDIDA ALBICANS; ESCHERICHIA COLI; HMGN2 PROTEIN; MICROBIAL SENSITIVITY TESTS; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; TRANSFORMATION, GENETIC;

EID: 24744432289     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2005.00132.x     Document Type: Article

References (26)

1. Boman HG. Peptide antibiotics and their role in innate immunity. Annu Rev Immunol 1995; 13: 61-92.
2. Garcia-Penarrubia P, Koster FT, Kelley RO, McDowell TD, Bankhurst AD. Antimicrobial activity of human natural killer cells. J Exp Med 1989; 169: 99-113.
3. Levitz SM, Mathews HL, Murphy JW. Direct antimicrobial activity of T cell. Immunol Today 1995; 16: 387-90.
4. Prokesova L, Dung DH, Trebichavsky I, Formankova E, Stepankova V, John C. Antimicrobial activity of human mononuclear leukocytes against Staphylococcus aureus. Folia Microbiol (Praha) 1994; 39: 428-34.
5. Kumar J, Okada S, Clayberger C, Krensky AM. Granulysin: a novel antimicrobial. Expert Opin Investig Drugs 2001; 10: 321-9.
6. Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Sillard R, et al. NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antimicrobial and antitumor activity. EMBO J 1995; 14: 1615-25.
7. Agerberth B, Charo J, Werr J, Olsson B, Idali F, Lindbom L, et al. The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 2000; 96: 3086-93.
8. Yang H, Huang N, Wu Q, Wang B. Isolation and characterization of an antimicrobial polypeptide from human LAK cells. Chin J Microbial Immunol 2003; 23: 241-3.
9. Landsman DO, McBride W, Bustin M. Chromosomal protein HMGN2. Complete human cDNA sequence and evidence for a multigene family. Nucleic Acids Res 1986; 17: 2301-14.
10. Tremethick DJ, Hyman L. High mobility group protein 14 and 17 can prevent the close packing of nucleosomes by increasing the strength of protein contacts in the linker DNA. J Biol Chem 1996; 271: 12009-16.
11. Vestner B, Bustin M, Gruss C. Stimulation of replication efficiency of a chromatin template by chromosomal protein HMGN2. J Biol Chem 1998; 273: 9409-14.
12. Lehtonen S, Lehtonen E. HMGN2 is an early marker of inductive interactions in the developing mouse kidney. Differentiation 2001; 67: 1541-63.
13. Selsted ME, Szklarek D, Lehrer RI. Purification and antimicrobial activity of antimicrobial peptides of rabbit granulocytes. Infect Immun 1984; 45: 150-4.
14. Ganz T, Selsted ME, Szklarek D, Harwig SSL, Daher K, Bainton DF, et al. Defensins, natural peptide antibiotics of human neotrophils. J Clin Invest 1985; 76: 1427-35.
15. Postnikov YV, Herrera JE, Hock R, Scheer U, Bustin M. Cluster of nucleosomes containing chromosomal protein HMGN2 in chromatin. J Mol Biol 1997; 274: 454-65.
16. Bustin M. Regulation of DNA-dependent activities by the functional motifs of the high-mobility group chromosomal proteins. Mol Cell Biol 1999; 19: 5237-46.
17. Hock R, Scheer U, Bustin M. Chromosomal protein HMG-14 and HMGN2 are released from mitotic chromosomes and imported into the nucleus by active transport. J Cell Biol 1998; 143: 1427-36.
18. Spieker N, Beitsma M, Sluis PV, Roobeek I, Dunnen JTD, Speleman F, et al. An integrated 5-Mb physical, genetic, and radiation hybrid map of a 1p36.1 region implicated in neuroblastoma pathogenesis. Genes Chromosomes Cancer 2000; 27: 143-52.
19. Ayer LM, Rubin RL, Dixon GH, Fritzler MJ. Antibodies to HMG proteins in patients with drug-induced autoimmunity. Arthritis Rheum 1994; 37: 98-103.
20. Frohm M, Gunne H, Bergman AC, Agerberth B, Bergman T, Boman A, et al. Biochemical and antimicrobial analysis of human wound and blister fluid. Eur J Biochem 1996; 237: 86-92.
21. Fernandes JMO, Saint N, Kemp GD, Smith VJ. Oncoryncin III: a potent antimicrobial peptide derived from the nonhistone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss. Biochem J 2003; 373: 621-8.
22. Tiozzo E, Rocco G, Tossi A, Romeo D. Wide-spectrum antibiotic activity of synthetic amphipathic peptides. Biochem Biophys Res Commun 1998; 249: 202-6.
23. Gennaro R, Zanetti M. Structural features and biological activities of the cathelicidin-derived antimicrobial peptides. Biopolymers 2000; 55: 31-49.
24. Yang YX, Feng Y, Wang BY. PCR-based site-specific mutagenesis of peptide antibiotic FALL-39 and its biologic activities. Acta Pharmacol Sin 2004; 25: 239-45.
25. Cabiaux V, Agerberth B, Johansson J, Homble F, Goormaghtigh E, Ruysschaert JM. Secondary structure and membrane interaction of PR-39, a Pro+Arg-rich antibacterial peptide. Eur J Biochem 1994; 224: 1019-27.
26. Agerberth B, Lee JY, Bergman T, Carlquist M, Boman HG, Mutt V, et al. Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antimicrobial peptides. Eur J Biochem 1991; 202: 849-54.