Granulysin: A novel antimicrobial

Expert Opinion on Investigational Drugs

Volumn 10, Issue 2, 2001, Pages 321-329

  Kumar, J ^a   Okada, S ^a   Clayberger, C ^a   Krensky, A M ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Antibiotic; Cytolytic T lymphocyte; Granulysin; Natural killer cell; Peptide

Indexed keywords

AMINO ACID DERIVATIVE; AMOEBAPORE DERIVATIVE; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ANTIPARASITIC AGENT; ARGININE; BOMBININ; CATHELICIDIN; CECROPIN; CELL EXTRACT; CYSTEINE; DEFENSIN; DISINFECTANT AGENT; GENE PRODUCT; GRANULYSIN; HISTATIN; MAGAININ DERIVATIVE; MESSENGER RNA; NEW DRUG; NK LYSIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROLINE; PROTEGRIN; PROTEIN DERIVATIVE; RANTES; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SPHINGOLIPID ACTIVATOR PROTEIN; SPHINGOMYELIN PHOSPHODIESTERASE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DRUG ACTIVITY; DRUG SELECTIVITY; ENTAMOEBA HISTOLYTICA; EUKARYOTIC CELL; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; MYCOBACTERIUM TUBERCULOSIS; NATURAL KILLER CELL; NONHUMAN; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; SWINE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ANTINEOPLASTIC AGENTS; APOPTOSIS; HUMANS; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035154381     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.10.2.321     Document Type: Review

References (42)

1. The isolation and sequence of a novel gene from a human functional T cell line
2. A human T cell-specific molecule is a member of a new gene family
3. Molecular cloning and characterization of WP-34, a phosphorylated human lymphocyte differentiation and activation antigen
4. A novel human T cell activation antigen that is a member of the immunoglobulin gene superfamily
5. Genomic structure and alternative splicing of 519, a gene expressed late after T cell activation
6. Processing, subcellular localization and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins
7. An anti-microbial activity of cytolytic T cells mediated by granulysin
8. Antiviral activity of granulysin
9. Anti-microbial peptides in mammalian and insect host defence
10. Anti-microbial peptides: An emerging concept in cutaneous biology
11. Animal anti-microbial peptides: An overview
12. Peptide antibiotics and their role in innate immunity
13. Biosynthesis of granulysin, a novel cytolytic molecule
14. Granulysin: A novel anti-microbial peptide of cytolytic T lymphocytes and natural killer cells
15. Identification of an anti-mycobacterial domain in NK-lysin and granulysin
16. NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, anti-bacterial and antitumour activity
17. Saposin fold revealed by the NMR structure of NK-lysin
18. Comparative modeling of amoebapores and granulysin based on the NK-lysin structure-structural and functional implications
19. An amphipathic helical motif common to tumourolytic polypeptide NK-lysin and pulmonary surfactant polypeptide SP-B
20. Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin
21. Immune responses to allografts. Primer on Transplantation
22. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
23. Differential effects of cytolytic T-cell subsets on intracellular infection
24. A direct anti-microbial effector mechanism of CD4+ T cells: Role of granulysin in leprosy
25. Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways
26. A distinct pathway of cell-mediated apoptosis initiated by granulysin
27. Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation
28. HSP27 inhibits cytochrome c-dependent activation of procaspase-9
29. Deficiency in caspase-9 or caspase-3 induces compensatory caspase
30. Peptide antibiotics
31. Identification of an anti-mycobacterial domain in NK-lysin and granulysin
32. Granulysin, a T cell product, kills bacteria by altering membrane permeability
33. A common cytolytic region in myotoxins, hemolysins, cardiotoxins and anti-bacterial peptides
34. Pore-forming peptide of Entamoeba histolytica: Significance of positively charged amino acid residues for its mode of action
35. Saposin proteins: Structure, function and role in human lysosomal storage disorders
36. Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein
37. Expression and characterization of recombinant human acyloxyacyl hydrolase, a leucocyte enzyme that deacylates bacterial lipopolysaccharides
38. Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full length and the alternatively spliced cDNAs
39. Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: Isolation, primary structure and pore formation in bacterial cytoplasmic membranes
40. The pore forming peptide of Entamoeba Histolytica, the protozoan parasite causing human amoebiasis
41. Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity
42. Molecular characterization of mitochondrial apoptosis-inducing factor