Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one

Oncology Reports

Volumn 14, Issue 1, 2005, Pages 41-46

  Shimizu, Shigetaka ^a   Suzuki, Mamoru ^a   Miyazawa, Keisuke ^a   Yokoyama, Tomohisa ^a   Ohyashiki, Kazuma ^a   Miyazaki, Kaori ^a   Abe, Akihisa ^a   Tomoda, Akio ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Differentiation; G1 arrest; Human malignant melanoma cells; Phenoxazine; Proliferation inhibition

Indexed keywords

2 AMINO 4,4ALPHA DIHYDRO 4ALPHA,7 DIMETHYL 3H PHENOXAZINE 3 ONE; 2-AMINO-4,4ALPHA-DIHYDRO-4ALPHA,7-DIMETHYL-3H-PHENOXAZINE-3-ONE; 3 AMINO 1,4A DIHYDRO 4A,8 DIMETHYL 2H PHENOXAZINE 2 ONE; 3 AMINOPHENOXAZONE; 3-AMINO-1,4A-DIHYDRO-4A,8-DIMETHYL-2H-PHENOXAZINE-2-ONE; 3-AMINOPHENOXAZONE; DNA FRAGMENT; MELANIN; OXAZINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL SURVIVAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; FLOW CYTOMETRY; GENETICS; HUMAN; MELANOMA; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; MELANINS; MELANOMA; OXAZINES;

EID: 24644524771     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Jemal A, Devesa SS, Hartge P and Tucker MA: Recent trends in cutaneous melanoma incidence among whites in the United States. J Natl Cancer Inst 93: 678-683, 2001. (Pubitemid 32492808)
2. Pawlik TM and Sodak VK: Malignant melanoma: current state of primary and adjuvant treatment. Oncol Hematol 45: 245-264, 2003. (Pubitemid 36299133)
3. Runkle GP and Znik AJ: Malignant melanoma. Am Fam Physician 49: 91-98, 1994. (Pubitemid 24019970)
4. Tomoda A, Yamaguchi J, Kojima H, Amemiya H and Yoneyama Y: Mechanism of o-aminophenol metabolism in human erythrocytes. FEBS Lett 196: 44-48, 1986. (Pubitemid 16048182)
5. Tomoda A, Arisawa M and Koshimura S: Oxidative condensation of 2-amino-4-methylphenol to dihydrophenoxazinone compound by human hemoglobin. J Biochem 110: 1004-1007, 1991.
6. Tomoda A, Hamashima H, Arisawa M, Kikuchi T, Tezuka Y and Koshimura S: Phenoxazinone synthesis by human hemoglobin. Biochim Biophys Acta 1117: 306-314, 1992.
7. Gao S, Takano T, Sada K, He J, Noda C, Hori-Tamura N, Tomoda A and Yamamura H: A novel phenoxazine derivative suppresses surface IgM expression in DT40 B cell line. Br J Pharmacol 137: 749-755, 2002. (Pubitemid 35404173)
8. Enoki E, Sada K, Qu X, Kyo S, Shahjahan Miah SM, Hatani T, Tomoda A and Yamamura H: The phenoxazine derivative Phx-1 suppresses IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells. J Pharmacol Sci 94: 329-333, 2004. (Pubitemid 38470743)
9. Iwata A, Yamaguchi T, Sato K, Izumi R and Tomoda A: Antiviral activity of 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one on poliovirus. Tohoku J Exp Med 200: 161-165, 2003.
10. Shimizu S, Suzuki M, Tomoda A, Arai S, Taguchi H, Hanawa T and Kamiya S: Phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tubercullosis mycobacteria: Tohoku J Exp Med 203: 47-52, 2004. (Pubitemid 38832654)
11. Mori H, Honda K, Ishida R, Nohira T and Tomoda A: Antitumor activity of 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one against Meth A tumor transplanted into BALB/c mice. Anticancer Drugs 11: 653-657, 2000.
12. Shimamoto T, Tomoda A, Ishida R and Ohyashiki K: Antitumor effects of a novel phenoxazine derivative on human leukemia cell lines in vitro and in vivo. Clin Cancer Res 7: 704-708, 2001. (Pubitemid 32707997)
13. Abe A, Yamane M and Tomoda A: Prevention of growth of human lung carcinoma cells and induction of apoptosis by a novel phenoxazinone, 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one. Anticancer Drugs 12: 377-382, 2001. (Pubitemid 32453444)
14. 2M accumulation and apoptosis. Oncol Rep 10: 1171-1176, 2003.
15. Meyskens FL and Buller BB: Characterization of the effects of different retinoids on the growth and differentiation of a human melanoma cell line and selected subclones. Cancer Res 40: 2194-2196, 1980.
16. Zhao X, Wakamatsu Y, Shibahara M, Nomura N, Geltinger C, Nakahara T, Murata T and Yokoyama KK: Mannosylerythritol lipid is a potent inducer of apoptosis and differentiation of mouse melanoma cells in culture. Cancer Res 59: 482-486, 1999. (Pubitemid 29048887)
17. Hata K, Hori K and Takahashi S: Role of p38 MAPK in lupeol-induced B16 2F2 mouse melanoma cell differentiation. J Biochem 134: 441-445, 2003. (Pubitemid 37288343)
18. Tomoda A, Arai S, Ishida R, Shimamoto T and Ohyashiki K: An improved method for the rapid preparation of 2-amino-4,4α-dihydro-4α,7- dimethyl-3H-phenoxazine-3-one, a novel antitumor agent. Biorg Med Chem Lett 11: 1057-1058, 2001. (Pubitemid 32327967)
19. Wu Z, Wu L, Li L, Tashiro S, Onodera S and Ikejima T: p53-Mediated cell cycle arrest and apoptosis induced by shikonin via a capase-9-dependent mechanism in human malignant melanoma A375-S2 cells. J Pharm Sci 94: 166-176, 2004. (Pubitemid 38405131)
20. Migotte B and Vayssiere JL: Mitochondria and apoptosis. Eur J Biochem 252: 1-15, 1998.
21. Yoshida A, Ueda T, Wano Y and Nakamura T: DNA damage and cell killing by camptothecin and its derivative in human leukemia HL-60 cells. Jpn J Cancer Res 84: 566-573, 1992.
22. Goldberg IH and Friedman PA: Antibiotics and nucleic acids. Annu Rev Biochem 40: 775-810, 1971.
23. Motohashi N Mitshcer LA and Meyer R: Potential antitumor phenoxazines. Med Res Rev 11: 239-294, 1991.
24. Eckert KG and Eyer P: Differences in the reactions of isometric ortho- and para-aminohenols with hemoglobin. Biochem Pharmacol 32: 1019-1027, 1983. (Pubitemid 13059202)