Single-cell microinjection of cytochrome c can result in gap junction-mediated apoptotic cell death of bystander cells in head and neck cancer

Head and Neck

Volumn 27, Issue 9, 2005, Pages 794-800

  Frank, Douglas K ^a,b   Szymkowiak, Bozena ^a   Josifovska Chopra, Olgica ^c   Nakashima, Torahiko ^d   Kinnally, Kathleen W ^c  

^a NEW YORK EYE AND EAR INFIRMARY   (United States)

^b BETH ISRAEL MEDICAL CENTER   (United States)

^c NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bystander effect; Gap junctions

Indexed keywords

CYTOCHROME C; GLYCYRRHETINIC ACID;

APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CANCER CELL CULTURE; CARCINOGENESIS; CELL COMMUNICATION; CELL METABOLISM; CONTROLLED STUDY; GAP JUNCTION; HEAD AND NECK CANCER; HOMEOSTASIS; HUMAN; HUMAN CELL; MICROINJECTION; MICROSCOPY; PHENOTYPE; PRIORITY JOURNAL; SINGLE CELL MICROINJECTION; SQUAMOUS CELL CARCINOMA;

APOPTOSIS; BYSTANDER EFFECT; CARCINOMA, SQUAMOUS CELL; CELL LINE; CONNEXIN 43; CYTOCHROMES C; FLUORESCENT DYES; GAP JUNCTIONS; GLYCYRRHETINIC ACID; HEAD AND NECK NEOPLASMS; HUMANS; ISOQUINOLINES; MICROINJECTIONS; MICROSCOPY; TRANSFECTION; VIDEO RECORDING;

EID: 24644492779     PISSN: 10433074     EISSN: None     Source Type: Journal    
DOI: 10.1002/hed.20235     Document Type: Article

References (23)

1. Yamasaki H. Gap junction intercellular communication and carcinogenesis. Carcinogenesis 1990;11:1051-1058.
2. Holder JW, Elmore E, Barrett JC. Gap junction function and cancer. Cancer Res 1993;53:3475-3485.
3. Loewenstein WR. Junctional intercellular communication and the control of growth. Biochim Biophys Acta 1979;560: 1-65.
4. Oyamada Y, Oyamada M, Fusco A, Yamasaki H. Aberrant expression, function and localization of connexins in human esophageal carcinoma cell lines with different degrees of tumorigenicity. J Cancer Res Clin Oncol 1994;120: 445-453.
5. Wilgenbus KK, Kirkpatrick CJ, Knuechel R, Willecke K, Traub O. Expression of Cx26, Cx32 and Cx 43 gap junction proteins in normal and neoplastic tissues. Int J Cancer 1992;51:522-529.
6. Azzam EI, de Toledo SM, Little JB. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from α-particle irradiated cells to nonirradiated cells. Proc Natl Acad Sci U S A 2001;98:473-478.
7. Azzam EI, de Toledo SM, Gooding T, Little JB. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat Res 1998;150: 497-504.
8. Frank DK, Frederick MJ, Liu TJ, Clayman GL. Bystander effect in the adenovirus-mediated wild-type p53 gene therapy model of human squamous cell carcinoma of the head and neck. Clin Cancer Res 1998;4:2521-2528.
9. Nagar S, Smith LE, Morgan WF. Characterization of a novel epigenetic effect of ionizing radiation: the death inducing effect. Cancer Res 2003;63:324-328.
10. George CH, Martin PE, Evans WH. Rapid determination of gap junction formation using HeLa cells microinjected with cDNAs encoding wild-type chimeric connexins. Biochem Biophys Res Comm 1998;247:785-789.
11. Muller M, Strand S, Hug H, et al. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J Clin Inv 1997;99:403-413.
12. El-Fouly MH, Trosko JE, Chang CC. Scrape loading and dye transfer. A rapid technique to study gap junctional intercellular communication. Exp Cell Res 1987;168: 422-430.
13. Zhivotovsky B, Orrenius S, Brustugun OT, Doskeland SO. Injected cytochrome c induces apoptosis. Nature 1998;391: 449-450.
14. Davidson JS, Baumgarten IM, Harley EH. Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid. Biochem Biophys Res Commun 1986;134: 29-36.
15. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257.
16. Krutovskikh VA, Piccoli C, Yamasaki H. Gap junction intercellular communication propagates cell death in cancerous cells. Oncogene 2002;21:1989-1999.
17. Azzam EI, de Toledo SM, Spitz DR, Little JB. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from α-particle-irradiated normal human fibroblast cultures. Cancer Res 2002;62:5436-5442.
18. Iyer R, Lehnert BE. Factors underlying the cell growth-related bystander responses to α particles. Cancer Res 2000;60:1290-1298.
19. Madhukar BV, Oh SY, Chang CC, Wade M, Trosko JE. Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-beta and peptide hormones in normal human keratinocytes. Carcinogenesis 1989;10:13-20.
20. Maldonado PE, Rose B, Loewenstein WR. Growth factors modulate junctional cell-cell communication. J Membr Biol 1988;106:203-210.
21. Warn-Cramer BJ, Cotrell GT, Burt JM, Lau AF. Regulation of connexin 43 gap junctional intercellular communication by mitogen-activated protein kinase. J Biol Chem 1998;273:9188-9196.
22. Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor α and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 1993;53:3579-3584.
23. Shin DM, Ro JY, Hong WK, Hittelman WN. Dysregulation of epidermal growth factor receptor expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 1994;54:3153-3159.